...Thalidomide is a drug used as a sedative, and is great use for treating prostate cancer and induction of drowsiness and sleep. Thalidomide had a trade name, which was called contergan. It was first introduced in 1957 by a West German pharmaceutical company called Chemie Grunenthal. In 1957, thalidomide has no information about the side effects, so people used it freely. In 1958, the drug was licensed to other countries, so it was becoming a popular drug in solving morning sickness. By 1961, researchers found a correlation between thalidomide and birth defects in children. Then in 1964, an israeli Professor was interested in the positive side effects of thalidomide. They eventually found that thalidomide has positive effects in treating other diseases, and that when the FDA approved it. Around the same time, scientists discovered the immunomodulatory properties when testing thalidomide with leprosy patients. In 2006, it was discovered that thalidomide is useful in treating Multiple Myeloma. In the past, Thalidomide was used for nausea in pregnant woman, but over time scientists...
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...Yeni Rojas Legal, Ethical and Social Values of Business Chapter 4 “Traditional Theories of Property and Profit” January 27, 2015 Abstract This paper examines chapter 4 Traditional Theories of Property and Profit. It starts off with the case study of New Protocol: How Drug’s Rebirth as Treatment for Cancer Fueled Price Rises, and the ethical challenge being faced by Celgne Corp. The company must choose between securing the financial wellbeing of their company or responding to the public’s need. We also examine the ethical positions of Milton Friedman and R. Edward Freeman in their respective essays found in Chapter 4 of the textbook as they are applied to the case study of " New Protocol: How Drug’s Rebirth as Treatment for Cancer Fueled Price Rises." Celgne Corp., in my opinion is a great example of a company that is facing the age-old question of who companies owe their loyalty to? The stakeholders who are investing in our company or the community we sell our products to and for whom the product is essentially developed for. While my belief is that in any business there is the need to make a profit and constantly grow not only the assets but also the stakeholder’s investment, one has to analyze up to what point it is fine to stop benefiting the company’s financial health and maintain the ethical responsibility to the public. It does not seem ethical to price gouge customers simply for the benefit of the stakeholders; especially when the cost to manufacture the...
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...Business Research Ethics Bobbie Stolze RES/351 October 15th, 2012 James Malachowski Business Research Ethics Today there are many cases of unethical business research that usually result in entire firms as well as individuals that are convicted and fined in the court of law. Unethical business research comes in many forms some of these forms are inappropriate questionnaires, research fraud, failure to maintain participant’s privacy, and even skewing research results. The following information is regarding scientific research fraud involving William McBride. McBride was an obstetrician who was found guilty of 24 counts of scientific fraud that ended up costing between five and seven million dollars after all was said and done. In 1980 McBride had announced that thalidomide was dangerous to women who are pregnant. He claimed that the drug would cause deformities of the limbs in mother’s unborn children. Several years later McBride had claimed that he completed research on another drug called Debendox, which is a drug used for treating morning sickness for pregnant women. McBride published this research and claimed that he has tested the drug on eight rabbits, and three of the rabbits ended up developing deformities because of the drug Debendox. Shortly following McBride’s research, the manufacturer of Debendox was forced to take the drug off the market even though there were only a few supporters of his research claim. It was later discovered by Phil Vardy was a scientist...
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...Psychological Effects of Street Drugs Krystal Colosimo Mohawk Valley Community College Abstract This paper explores the psychological effects of street drugs, classified as legal, illegal and controlled substances. The legal drugs that I cover are caffeine, alcohol and nicotine. The illegal are marijuana, cocaine, ecstasy and heroin. I will also discuss controlled substances, but mainly in reference to prescription pills. I discuss the short-term and long-term effects of all the drugs I cover as well as withdrawal symptoms. I will close with drug abuse treatment help and support and follow with my conclusion. Psychological Effects of Street Drugs A street drug is defined as any substance taken for nonmedical purposes. They can be legal or illegal and are comprised of amphetamines, barbiturates, opiates, psychoactive drugs and as well as natural sources. A drug is a chemical substance that has known biological effects on humans. For this paper I will be discussing drugs under the three categories of being legal, illegal and controlled substances. The most common legal drugs I will discuss are caffeine, alcohol and nicotine. The more common illegal drugs that I will discuss are marijuana, cocaine, ecstasy and heroin. There are numerous controlled substances as well and it is defined as a drug or chemical that is regulated by the government. For controlled substances I will only be covering prescription pills. Legal Drugs ...
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...Running Head: MEDICAL PLURALISM IN WESTERN SOCIETY 1 Course Project: Medical Pluralism in Western Society July 31st, 2015 Introduction & Objectives: Through the course of Health and Society, we explore different techniques and remedies for the use of individual’s health. We have come to an understanding that even in a Western society that is dominated by western biomedicine, there are still correspondence with alternative medicine and spiritual healing that is used when dealing with diseases and other related health illnesses. Since Canada has a multicultural society, individuals may visit doctors, psychologists, paediatrician, and physicians, and at other times we seek chiropractic solutions, relaxation techniques, massage, prayer, herbal therapies, special diets, folk remedies, acupuncture, yoga, or homeopathy in pursuit of having a healthier life. There is not always a conflict between non-western medicine and Western biomedicine. Though the two may have different forms, procedures, norms, regulations, and values, Canada has come to rely on both for a solution to their health. The process by which people take advantage of a variety of health techniques and strategies that are based on different models of health and healing is what has come to be known as medical pluralism. (Woronko) For the objective of the interview, I was tasked...
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...Journal of Economic Literature 2010, 48:4, 935–963 http:www.aeaweb.org/articles.php?doi=10.1257/jel.48.4.935 Quality Disclosure and Certification: Theory and Practice David Dranove and Ginger Zhe Jin* This essay reviews the theoretical and empirical literature on quality disclosure and certification. After comparing quality disclosure with other quality assurance mechanisms and describing a brief history of quality disclosure, we address two sets of theoretical issues. First, why don’t sellers voluntarily disclose through a process of “unraveling” and, given the lack of unraveling, is it desirable to mandate seller disclosure? Second, when we rely on certifiers to act as the intermediary of quality disclosure, do certifiers necessarily report unbiased and accurate information? We further review empirical evidence on these issues, with a particular focus on healthcare, education, and finance. The empirical review covers quality measurement, the effect of third-party disclosure on consumer choice and seller behavior, as well as the economics of certifiers. ( JEL D18, K32, L15, M31) 1. Introduction A young couple expecting their first child might consult healthgrades.com hospital rankings to help choose where to deliver their baby. A year later, the couple decides they need an SUV and consults performance specifications provided by manufacturers and reads Consumer Reports to learn about reliability. Soon thereafter, the couple ...
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...Actions Regarding the Painkiller Vioxx Rod Carveth, Marywood University Claire Ferraris, Western Oregon University Nick Backus, Western Oregon University Abstract In this paper we demonstrate how to focus an empirical application in reaching an ethical decision by working with the Potter Box, a model created by Ralph Potter as an analytical tool assessing the ethics of corporate decision-making, The facts emerging in news accounts regarding lawsuits against the pharmaceutical company Merck and its painkiller Vioxx are analyzed for ethical consideration. Utilizing the Potter Box model, the case against Merck can be interpreted and studied in light of ethical considerations. The results demonstrate not only how a decision is argued, but what is missing in the overall consideration for the decision. Introduction The mythos of freedom and responsibility in the United States is premised on the ethical actions of members of the society, particularly those in positions of power. And ethics in communication takes a place of preeminence since the words spoken by authorities are often all a public relies upon to pass judgment. How is the citizen or the communication analyst to evaluate the ethics of the utterances of others? And how does the communicator determine the ethical appropriateness of a planned message? This paper is an introduction to an accessible method of ethical decision-making in communication. The Potter Box allows both student and scholar to analyze the ethical responsibilities...
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...related by their chemical structure, the way they work or if they are used for the same purpose (Pubmed Health, 2012). A cholinergic stimulant is a class of drugs used to increase activity at acetylcholine synapses and can be further subdivided into two categories; direct and indirect acting cholinergic stimulants. This categorization is based on their mechanisms of action and specificity for clinical use (Ciccone, 2007). Direct-acting cholinergic stimulants increase activity at the acetylcholine synapses by binding directly with the cholinergic receptor on the other hand; indirect-acting cholinergic stimulants put forth the same effect by inhibiting the acetylcholinesterase enzyme situated on the cholinergic synapse. For the purpose of this paper, an analysis of indirect acting cholinergic stimulants will be completed, with focus on Pyridosigmine and Prostigmin and their implications to physical therapy practice. Indirect-Acting Cholinergic Stimulants Indirect-acting cholinergic stimulants are also known as Cholinesterase inhibitors or Anticholinesterase agents. Cholinesterase inhibitors increase activity at cholinergic synapses by preventing the acetylcholinesterase enzyme from breaking down acetylcholine (ACh) after its release from the presynaptic terminal. Cholinesterase inhibitors inhibit acetylcholinesterase thus allowing more acetylcholine to remain at the synapse which results in an increase in cholinergic synaptic transmission (Ciccone, 2007). For circumstances where acetylcholine...
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...plasma cells, “myeloma” refers to a tumor of the bone marrow, and “multiple” refers to more than one area of the bone marrow being affected (Mangan, 2006, p. 64hn1). Because the disease is incurable, and because only 30 percent of patients survive longer than five years after diagnosis, living with multiple myeloma can be difficult for patients and their families (Mangan, 2006, p. 64hn1). As health care providers on the front lines of patient care, nurses must be aware of the multi-system manifestations of multiple myeloma, be able to make the assessments needed to identify and prevent complications related to the disease and its treatment regimen, and be ready to provide patients and their families with knowledge and support. In this paper, the author will first provide a full description of multiple myeloma, including etiology and risk factors, pathophysiology, diagnostic tests, and treatment. This accomplished, the author will apply the stages of the nursing process to nursing care...
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...WHY IS PRODUCT OR SERVICE DESIGN IMPORTANT? Service design is an activity of organizing and planning people, communication and material components in order to improve service quality. It is the interaction between the service provider and customers and the customers' experience. A service is anything that is done to or for a client and is created and delivered simultaneously. Product Design combines ergonomics with product and business knowledge to generate ideas and concepts and convert them into physical and usable objects or services. IMPORTANCE OF PRODUCT DESIGN AND SERVICE DESIGN a) Customer Satisfaction and Sustainability Organizations need to continually satisfy their customers to be successful in the marketplace. They are able to do this by improving current products or by designing new ones. b) Reliability Product and Service design ensures reliability. This is a measure of the ability of a product, a part, service, or an entire system to perform its intended function under a prescribed set of conditions. c) Consistent Product life cycle For example, a firm may have produced four different products and each product may have had a product life cycle of ten years. In this case, the firm must design four new products every ten years. Today, in order to be competitive, this firm may produce eight different products with a life cycle of only five years; this firm must introduce eight new products in five years. That represents sixteen new products...
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...U.S. Food and Drug Administration (FDA) drug review bears a structural similarity to many decisions made by other regulatory agencies: high uncertainty, low reversibility, avoidance of observable error, and high political stakes that induce lobbying by interested parties. This project explores the policy lessons to be learned from viewing FDA drug review as a politically shaped exercise in information processing. I argue that the incentives facing regulators induce limits on the degree to which drug review can be accelerated, that the same incentives could render privatization initiatives problematic, and that political pressures could play a useful role in identifying priority drugs. Patients, more than pharmaceutical firms, shape the political costs to the FDA of delaying drug approval. Consider two hypothetical consumers, one a pharmaceutical consumer (“patient”) who wishes to try a new drug for some ailment, the other a vitamin consumer who wishes to take zinc supplements to ward off a cold or flu. There are few institutional restrictions upon the consumption decisions of the vitamin consumer, at least in the United States. She is free to purchase vitamin products over the counter, and the vitamin manufacturer is free to sell them without prior authorization or licensing. Not so with pharmaceuticals. The marketplace for pharmaceuticals is one of the most highly regulated industries in the U.S. economy.1 To use any new pharmaceutical product, the patient must secure the...
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...Applied Statistical Methods Larry Winner Department of Statistics University of Florida February 23, 2009 2 Contents 1 Introduction 1.1 Populations and Samples . . . . . . . . . . . 1.2 Types of Variables . . . . . . . . . . . . . . . 1.2.1 Quantitative vs Qualitative Variables 1.2.2 Dependent vs Independent Variables . 1.3 Parameters and Statistics . . . . . . . . . . . 1.4 Graphical Techniques . . . . . . . . . . . . . 1.5 Basic Probability . . . . . . . . . . . . . . . . 1.5.1 Diagnostic Tests . . . . . . . . . . . . 1.6 Exercises . . . . . . . . . . . . . . . . . . . . 7 7 8 8 9 10 12 16 20 21 25 25 29 29 29 32 32 32 32 32 35 35 37 38 38 39 40 42 42 44 48 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Random Variables and Probability Distributions 2.1 The Normal Distribution . . . . . . . . . . . . . . . . . . 2.1.1 Statistical Models . . . . . . . . . . . . . . . . . 2.2 Sampling Distributions and the Central Limit Theorem 2.2.1 Distribution of Y . . . . . . . . . . . . . . . . . . 2.3 Other Commonly Used Sampling Distributions . . . . . 2.3.1 Student’s...
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...The Decline and Fall of Literature November 4, 1999 ANDREW DELBANCO E-mail Print [pic]Share [pic] [pic]In Plato’s Cave[pic] by Alvin Kernan A couple of years ago, in an article explaining how funds for faculty positions are allocated in American universities, the provost of the University of California at Berkeley offered some frank advice to department chairs, whose job partly consists of lobbying for a share of the budget. “On every campus,” she wrote, “there is one department whose name need only be mentioned to make people laugh; you don’t want that department to be yours.”1 The provost, Carol Christ (who retains her faculty position as a literature professor), does not name the offender—but everyone knows that if you want to locate the laughingstock on your local campus these days, your best bet is to stop by the English department. The laughter, moreover, is not confined to campuses. It has become a holiday ritual for The New York Times to run a derisory article in deadpan Times style about the annual convention of the Modern Language Association, where thousands of English professors assemble just before the new year. Lately it has become impossible to say with confidence whether such topics as “Eat Me; Captain Cook and the Ingestion of the Other” or “The Semiotics of Sinatra” are parodies of what goes on there or serious presentations by credentialed scholars.2 At one recent English lecture, the speaker discussed a pornographic “performance artist”...
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...Psychology Not to be confused with Phycology, Physiology, or 1 Etymology Psychiatry. Further information: Outline of psychology and Index The word psychology literally means, “study of the soul" of psychology articles (ψυχή psukhē, “breath, spirit, soul” and -λογία -logia, “study of” or “research”).[10] The Latin word psycholoPsychology is an academic and applied discipline that gia was first used by the Croatian humanist and Latinist involves the scientific study of mental functions and Marko Marulić in his book, Psichiologia de ratione anbehaviors.[1][2] Psychology has the immediate goal of imae humanae in the late 15th century or early 16th understanding individuals and groups by both establish- century.[11] The earliest known reference to the word ing general principles and researching specific cases,[3][4] psychology in English was by Steven Blankaart in 1694 and by many accounts it ultimately aims to benefit in The Physical Dictionary which refers to “Anatomy, society.[5][6] In this field, a professional practitioner or which treats the Body, and Psychology, which treats of researcher is called a psychologist and can be classified the Soul.”[12] as a social, behavioral, or cognitive scientist. Psychologists attempt to understand the role of mental functions in individual and social behavior, while also exploring the physiological and biological processes that underlie cognitive functions and behaviors. 2 History Psychologists explore concepts such as perception...
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...University of Rochester Abstract Understanding human behavior is fundamental to understanding how organizations function, whether they are profit-making firms, non-profit enterprises, or government agencies. Much disagreement among managers, scientists, policy makers, and citizens arises from substantial differences in the way we think about human nature—about their strengths, frailties, intelligence, ignorance, honesty, selfishness, and generosity. In this paper we discuss five alternative models of human behavior that are commonly used (though usually implicitly). They are the Resourceful, Evaluative, Maximizing Model (REMM), Economic (or Money Maximizing) Model, Psychological (or Hierarchy of Needs) Model, Sociological (or Social Victim) Model, and the Political (or Perfect Agent) Model. We argue that REMM best describes the systematically rational part of human behavior. It serves as the foundation for the agency model of financial, organizational, and governance structure of firms. The growing body of social science research on human behavior has a common message: Whether they are politicians, managers, academics, professionals, philanthropists, or factory workers, individuals are resourceful, evaluative maximizers. They respond creatively to the opportunities the environment presents, and they work to loosen constraints that prevent them from doing what they wish. They care about not only money, but about almost everything—respect, honor, power, love, and the welfare of others...
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