Hemophilia & Transposons Hemophilia is an inherited genetic disorder that impairs the body’s ability to coagulate blood or control blood clotting. Hemophiliacs have problems in the blood coagulation mechanism and blood platelets and/or blood vessel defects that cause the individual to have problems forming blood clots to stop bleeding. The individuals tend to bleed for longer periods then normal individuals. Hemophiliacs do not bleed more intensely than normal individuals but due to the length of time for a clot to form their volume of blood loss is more severe.This can be deadly or debilitating in injuries to the brain. Minor injuries can lead to extreme blood loss over hours or days that require hospital attention. There are two main types of Hemophilia, Hemophilia A and Hemophilia B. Both are recessive X-linked chromosome disorder that are more prevalent in males than females. Hemophilia A is the most common type affecting 1 in 5,000 males. It is due to a deficiency in clotting factor VIII, an essential blood clotting protein. Hemophilia B is less common and affects 1 in 30,000 males. It is due to a deficiency in clotting factor IX which is a serine protease of the coagulation system. Females are usually asymptomatic carriers of the disorder. The defective gene can either be a new mutation in the X-chromosome or can inherited either from her father or mother. Hemophilia is a Class I transposons. This is a retrotransposons that transcribes DNA into RNA and then uses reverse transcriptase to make a copy of the DNA from the RNA and inserts it into a new location in the gene. Reverse transcriptase uses RNA as a template via a DNA polymerase. Retrotransposons are created in the gene by a “copy and paste” mechanism and the copy is made in the RNA. It is caused by an insertion of a LINE (long interspread elements) transposons into the gene of