BMC Neurology (2001) 1:3

http://www.biomedcentral.com/1471-2377/1/3

BMC Neurology (2001) 1:3 Research article

Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype
Address: 1L.Boltzmann Institute of Clinical Neurobiology, Baumgartner Hoehe 1, B-Bldg., A-1140 Vienna, Austria, 2Department of Neuropathology, University of Munster School of Medicine, Munster, Germany and 3Cognitive Neuropharmacology Unit, H.M. Jackson Foundation, Bethesda, Md, USA E-mail: Kurt A Jellinger* - kurt.jellinger@univie.ac.at; Werner Paulus - werner.paulus@uni-muenster.de; Christian Wrocklage - christian.wrocklage@uni-muenster.de; Irene Litvan - ilitvan@dvhip.org *Corresponding author

Kurt A Jellinger*1, Werner Paulus2, Christian Wrocklage2 and Irene Litvan3

Published: 30 July 2001 BMC Neurology 2001, 1:3 This article is available from: http://www.biomedcentral.com/1471-2377/1/3

Received: 29 June 2001 Accepted: 30 July 2001

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Abstract
Background and Purpose: The impact of traumatic brain injury (TBI) on the pathogenesis of Alzheimer disease (AD) is still controversial. The aim of our retrospective autopsy study was to assess the impact of TBE and ApoE allele frequency on the development of AD. Material and Methods: We examined 1. the incidence of AD pathology (Braak stageing, CERAD, NIA-Reagan Institute criteria) in 58 consecutive patients (mean age ± SD 77.0 ± 6.8 years) with residual closed TBI lesions, and 2. the frequency of TBI residuals in 57 age-matched autopsy proven AD cases. In both