Vincent Willem van Gogh was born on 30 March 1853 in Groot-Zundert, a village close to Breda, in the predominantly Catholic province of North Brabant in the southern Netherlands. He was the oldest surviving child of Theodorus van Gogh, a minister of the Dutch Reformed Church, and Anna Cornelia Carbentus. Vincent was given the name of his grandfather, and of a brother stillborn exactly a year before his birth. The practice of reusing a name was not unusual. Vincent was a common name in the Van Gogh family: his grandfather, Vincent (1789–1874), had received his degree of theology at the University of Leiden in 1811. Grandfather Vincent had six sons, three of whom became art dealers, including another Vincent -referred to in the letters as "Uncle Cent". Grandfather Vincent had perhaps been named in turn after his own father's uncle, the successful sculptor Vincent van Gogh (1729–1802). Art and religion were the two occupations to which the Van Gogh family gravitated. His brother Theodorus "Theo" was born on 1 May 1857. He had another brother, Cor, and three sisters: Elisabeth, Anna, and Willemina "Wil".
Vincent was a serious, silent and thoughtful child. He attended the village school at Zundert from 1860, where a single Catholic teacher taught around 200 pupils. From 1861, he and his sister Anna were taught at home by a governess, until 1 October 1864, when he was placed in Jan Provily's boarding school at Zevenbergen about 20 miles (32 km) away. He was distressed to leave his family home. On 15 September 1866, he went to the new middle school, Willem II College in Tilburg. Constantijn C. Huysmans, a successful artist in Paris, taught Van Gogh to draw at the school and advocated a systematic approach to the subject. Vincent's interest in art began at an early age. He began to draw as a child and continued making drawings throughout the years leading to his decision to become an artist. Though well-done and expressive, his early drawings do not approach the intensity he developed in his later work. In March 1868, Van Gogh abruptly left school and returned home. A later comment on his early years was in an 1883 letter to Theo in which he wrote, "My youth was gloomy and cold and sterile."
In July 1869, his uncle Cent helped him obtain a position with the art dealer Goupil & Cie in The Hague. After his training, in June 1873, Goupil transferred him to London, where he lodged at 87 Hackford Road, Brixton, and worked at Messrs. Goupil & Co., 17 Southampton Street. This was a happy time for Vincent; he was successful at work and was, at 20, earning more than his father. Theo's wife later remarked that this was the happiest year of his life. He fell in love with his landlady's daughter, Eugénie Loyer, but when he finally confessed his feelings to her, she rejected him, saying that she was secretly engaged to a former lodger. He became increasingly isolated and fervent about religion; his father and uncle arranged for him to be transferred to Paris, where he became resentful at how art was treated as a commodity, a fact apparent to customers. On 1 April 1876, Goupil terminated his employment.
Van Gogh returned to England for unpaid work as a supply teacher in a small boarding school in Ramsgate. When the proprietor of the school relocated to Isleworth, Middlesex, Van Gogh moved with him, taking the train to Richmond and the remainder of the journey on foot. The arrangement did not work out and he left to become a Methodist minister's assistant, following his wish to "preach the gospel everywhere". At Christmas, he returned home and found work in a bookshop in Dordrecht for six months. He was not happy in this new position, and he spent much of his time either doodling or translating passages from the Bible into English, French, and German. According to his roommate of the time, a young teacher named Görlitz, Van Gogh ate frugally, and preferred not to eat meat.

Van Gogh's religious zeal grew until he felt he had found his true vocation. To support his effort to become a pastor, his family sent him to Amsterdam to study theology in May 1877, where he stayed with his uncle Jan van Gogh, a naval Vice Admiral. Vincent prepared for the entrance exam with his uncle Johannes Stricker, a respected theologian who published the first "Life of Jesus" in the Netherlands. Van Gogh failed the exam, and left his uncle Jan's house in July 1878. He then undertook, but failed, a three-month course at the Vlaamsche Opleidingsschool, a Protestant missionary school in Laeken, near Brussels.
In January 1879, he took a temporary post as a missionary in the village of Petit Wasmes in the coal-mining district of Borinage in Belgium at Charbonnage de Marcasse, Van Gogh lived like those he preached to, sleeping on straw in a small hut at the back of the baker's house where he was staying. The baker's wife reported hearing Van Gogh sobbing at night in the hut. His choice of squalid living conditions did not endear him to the appalled church authorities, who dismissed him for "undermining the dignity of the priesthood". He then walked to Brussels, returned briefly to the village of Cuesmes in the Borinage, but gave in to pressure from his parents to return home to Etten. He stayed there until around March the following year, a cause of increasing concern and frustration for his parents. There was particular conflict between Vincent and his father, who made inquiries about having Vincent committed to the lunatic asylum at Geel.
He returned to Cuesmes, where he lodged until October with a miner named Charles Decrucq. He became interested in the people and scenes around him, and recorded his time there in his drawings, following Theo's suggestion that he take up art in earnest. He traveled to Brussels that autumn, intending to follow Theo's recommendation to study with the prominent Dutch artist Willem Roelofs, who persuaded him—in spite of his aversion to formal schools of art—to attend the Académie Royale des Beaux-Arts in Brussels, where he registered on 15 November 1880. At the Académie, he studied anatomy and the standard rules of modeling and perspective, about which he said, "you have to know just to be able to draw the least thing." Van Gogh aspired to become an artist in God's service, stating: "to try to understand the real significance of what the great artists, the serious masters, tell us in their masterpieces, that leads to God; one man wrote or told it in a book; another in a picture."