describe findings of reduced limbic brain structures in brains of depressed patients in particular a reduction in mass of the hippocampus and PFC. They also described preclinical studies which found participants who were exposed to stress regularly, in the hippocampus and PFC of their brains there was evidence of neuronal atrophy as well as loss of glial cells and neuronal cells seem to contribute to mood disorders such as MDD. Duman and Li (2012) highlighted that brain-derived neurotrophic factor (BDNF)
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1,4-Diaryl-azetidin-2-ones John W. Clader et al (J. Med. Chem. 1996, 39, 3684-3693) reported a series of azetidinone cholesterol absorption inhibitors related to compound 2(6 in paper). They focused on detailed structure-activity relationship of azetidinone compounds to probe the effect and sensitivity of the nature and pattern of substitution on the hypocholesterolemic activity in 7-day cholesterol-fed hamster model. Investigation identified that 4-alkoxyphenyl and absolute stereochemistry at
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they do? Ever wonder how their brain works? The brain and gender have a lot to do with that. I hope to inform people and explain or answer some of the questions they might have about the brain or how or why someone acts the way they do. Multitasking, size, behavior and maturity level, 13 year old brain vs. 70 year old brain, and growth all play a factor in this. Multitasking is something the female brain can do at a higher level. Research has shown that the male brain just can't simply handle doing
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Deep brain stimulation (DBS) is a neurosurgical procedure used as treatment for obsessive compulsive disorder (OCD) and other illnesses. During this procedure, the brain is stimulated in specific areas using electrodes. DBS started being used in the 80s as treatment severe tremors and Parkinson's disease. It was not until recently that this treatment began being used for OCD patients. Deep brain stimulation should not be used as treatment for OCD, because it is a highly experimental procedure and
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Agonist vs. Antagonist Knowing what drugs do to our bodies is extremely important. We need to know what to expect and what not to expect. To do this, many drugs are classified either as agonists or antagonists, which gives us information about the mode of action of that drug. These 2 are opposites of each other in the sense that the former forces an action to happen whereas the latter prevents an action from happening. In order to better understand this concept, let us see first understand how a
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Task 1: Jay Vidyarthi - Sonic Cradle “Mindfulness can be thought of as a moment-to-moment, non-judgmental awareness, cultivated by paying attention in a specifc way, that is, in the present moment, and as non-reactively, as non-judgmentally, and open heartedly as possible.” - Jon Kabat-Zinn (p.108, “Coming to our senses”) In “Sonic Cradle” the user is suspended horizontally, in a leaned back sitting position, in a completely dark room. Sensors mounted around the subjects chest generates ambient spatial
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Some people think that they are completely tone deaf and can't sing for their life, but that can easily be changed.( except for my dad) There are so many different parts of the arts there is acting, dancing, painting, and so much more activities but Singing Is an fascinating way to express oneself. It's an exciting activity for everyone because with some vocal training you find your uniqueness of your voice and can join different groups. Vocal training is one of the key points in singing. And
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Introduction Pilocarpine is a muscarinic receptor agonist that stimulates the activity of the muscarinic receptor upon binding (Desaki et al., 1998). When pilocarpine binds to a specific binding site on the receptor, a conformational change from a closed to open conformation is induced. (Auerbach, 2014) This open conformation has a much greater affinity for binding agonist (Auerbach, 2014). The increase in affinity leads to higher stimulation of the receptor (Aurbach, 2014). This continual stimulation
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are chemicals in the body that the nerve cells in the brain called neurons us to communicate with each other in the nervous system. The most important neural transmitter in the fear response in called
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Multiple Sclerosis My symptoms started off with extreme muscle spasms and cramps. It would get worse when I was on my monthly. I was walking and running at the time to lose some weight that I thought was causing the muscle aches, headaches, and the pain that I was feeling in my whole body. One day it got overwhelming. It was August 17th, 2007. I felt like I was getting the life squeezed out of me and my mind was racing the whole time while experiencing difficulty speaking, walking, and trying to
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