Sickle Cell Disease Sickle cell disease is a genetic hemolytic anemia that is considered a significant public health issue (2). It is mostly common among black Americans and black Africans (3). Every year there are almost sixty million carriers of SCD, and 1.2 million sickle cell homozygotes are added worldwide (2). Not only 1 in 400 African Americans is affected by SCD, but also other families that have any ethnic background (3). Approximately 70% of inherited hemoglobin disorders seen worldwide
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is a heritable disorder of bone formation resulting in low bone mass and a propensity to fracture. It exhibits a broad range of clinical severity, ranging from multiple fracturing in utero and perinatal deaths to normal adult stature and a low fracture incidence. The disorder is currently classified into seven types based on differences in bone architecture. In addition to its primary effect on the skeletal system, the alterations in connective tissue may affect several extra skeletal structures, such
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Resveratrol help protecting your brain and the nervous system by crossing the blood-brain barrier. These antioxidant properties promote: •
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The Sphingolipidoses are a group of Lysosomal Storage Disorders (LSDs), which individually are considered rare diseases; however, their collective incidence is approximately 1 in 5000-9000 live births. This number is dependent on the location and population, with some regions presenting a much higher proportion of cases than others. These diseases consequently together comprise a vast proportion of the healthcare system and therefore there is a need to investigate novel treatments as well as more
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• Gaucher disease (glucocerebrosidase deficiency) is a rare autosomal recessive genetic disorder. It is classified as a lysosomal storage disorder and is determined to be one of the most prevalent. • Gaucher disease (GD) is an inherited disorder caused by a lysosomal enzyme deficiency. It is an autosomal recessive disease. This means that both parents must carriers of the mutation in order to pass it to their child. This disease occurs when there is a build-up of a lipid, called glucosylceramide
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functions of the various types of muscle * Skeletal- limb movement * Cardiac- heart movements * Smooth- movements of hollow organs 2. Describe the involvement of connective tissue in a skeletal muscle * Endomysium- surrounds and fills up spaces between individual muscle fibers * Perimysium- ensheaths muscle fascicles (bundles of muscle fibers) * Epimysium- ensheaths the whole muscle 3. Name the components of a skeletal muscle fiber and describe their function *
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Marfan syndrome is a genetic disorder that affects the body’s connective tissue. Connective tissue holds all the body’s cells, organs and tissue together. It also plays an important role in helping the body grow and develop properly. About 1 in 5,000 people have Marfan syndrome, including men and women of all races and ethnic groups. There is no cure for Marfan syndrome. To develop one, scientists may have to identify and change the specific gene responsible for the disorder before birth and medical
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hypersensitivity reaction results from the binding of antibodies to normal or altered cell surface antigens (Fisher, 2012). The antibody-dependent mechanisms that cause tissue injury and disease are illustrated in the figure below 2.0 Antibody- Dependent Mechanism The antibody-dependent mechanisms that cause tissue injury and disease are illustrated in the figure below; 2.1: Opsonization and Phagocyctosis The depletion of cells coated with antibodies is due to phagocytosis. The phagocyte Fc receptor recognizes
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A)|connective tissue| B)|muscle tissue| C)|skeletal tissue| D)|epithelial tissue| E)|nervous tissue| Ans:|D| |Link to: Introduction| 2.|A scientist who examines tissue changes that might indicate disease is called a| A)|histologist.| B)|radiologist.| C)|pathologist.| D)|epidemologist| E)|endocrinologist.| Ans:|C| |Link to: Types of Tissue| 3.|The tissue lining body cavities is| A)|epithelial tissue.| B)|connective tissue.| C)|skeletal tissue.| D)|muscle tissue.| E)|nervous
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bodily movement produced by skeletal muscles that requires energy expenditure, (WHO, 2015). There are various concepts on health and wellbeing and remains a complex subject but according to Claude Bouchard, Health is a human condition with physical, psychological, social dimensions, each characterized on a continuum with positive and negative poles. Positive health is associated with capacity to enjoy life and withstand challenges; it is not merely the absence of disease. (Bouchard, 1990). Wellbeing
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