MULTIPEL MYELOOM : Prof. Dr. Michel Delforge Hematologie Universitaire Ziekenhuizen Leuven Samenvatting De perspectieven voor patiënten met multipel myeloom zijn de voorbije jaren sterk verbeterd. Gedurende de voorbije jaren is de behandeling geëvolueerd naar een geïntegreerde aanpak, gebaseerd op beter ziekte-inzicht en nieuwe geneesmiddelen. Een eerste revolutie was er begin van de jaren negentig door de introductie van de hoge dosis chemotherapie gevolgd door autologe stamceltransplantatie
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was multiple myeloma and chronic lymphocytic leukemia. Before the video discussed how the diseases took control of the body, they went into detail about blood. Blood is vital to our body because it contains liquid plasma and blood cells. Red blood cells have a very important job to carry oxygen throughout our body, and white blood cells fight infections. All blood cells are made in the bone marrow, which is where blood cancers do the most damage. The next part of the video discussed multiple myeloma
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The drug is a dipeptide made up of a pyrazinoic acid, phenylalanine, and leucine with boronic acid. Bortezomib works by inhibiting, or changing, the proteolytic action of the proteasome. The drug turns off the adhesion of multiple myeloma cells and as a result, cancer cells are no longer able to build up in the blood. Also with this drug, the proteasome is no longer able to break down cyclins which are needed to complete mitosis of the cancer cells. Additionally, bortezomib inhibits
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or the patient has their stem cells collected via a central line in a process called apheresis. This can take multiple collections to ensure enough stem cells for transplantation. Both procedures need to be meticulously planned and all support medications given to ensure successful collection. There are many cancers that stem cell transplants are commonly used for. Multiple myeloma, acute lymphoblastic leukemia, Hodgkin’s disease and chronic myelogenous leukemia are more commonly treated with
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Case #1: Jim and Jane Magnolia have tried for years to conceive a child, with no success. So instead, they have decided to adopt a child. They have found a beautiful little girl named Emma who has been given up by her mother. The child, only two weeks old, was born at the mother’s home and has not received any medical attention beyond that given by EMS during the birth. 1. Should the parents be particularly concerned with Emma’s lack of medical attention? Yes, the child has only been seen by local
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Case Studies Weeks 1-4 Advanced Anatomy and Physiology Name: Robert Mixon Student ID#: 4321101 Case Studies – Instructions: Type your answers IN RED and use your textbook and other resources such as the ones listed below to help you answer the questions. Merck Manual of Diagnosis and Therapy: http://www.merck.com/mmpe/index.html MedlinePlus: Medical Dictionary: http://www.nlm.nih.gov/medlineplus/mplusdictionary.html E-medicine from WebMD: http://emedicine.medscape.com/________________________________________
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Thalidomide’s history is one of the darkest in pharmaceutical history. Today, Thalidomide is still used in the treatment of leprosy and multiple myeloma. Till date Thalidomide’s exact mode of action, essential to its efficacy is unclear and research in the last decade has led to the proposal of 16 possible mechanisms. Details of Thalidomide’s molecular mechanism and its molecular targets can help to reveal analogues lacking the teratogenic effects. This report will particularly focus on some of the
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* THALIDOMIDE * By: KAUSHIK DOWARAH * The thalidomide disaster is one of the darkest episodes in pharmaceutical research history. The drug was marketed as a mild sleeping pill safe even for pregnant women. However, it caused thousands of babies worldwide to be born with malformed limbs. The damage was revealed in 1962. Before then, every new drug was seen as beneficial. Now there was suspicion and rigorous testing. * SYNTHESIS AND EARLY USE * Thalidomide was developed in the 1950s by
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treating other diseases, and that when the FDA approved it. Around the same time, scientists discovered the immunomodulatory properties when testing thalidomide with leprosy patients. In 2006, it was discovered that thalidomide is useful in treating Multiple Myeloma. In the past, Thalidomide was used for nausea in pregnant woman, but over time scientists
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| 2012 | | Leukemia and Lymphoma Society Tawanda Bryant | [Leukemia and Lymphoma Society] | The Leukemia & Lymphoma Society (LLS) is: Cure leukemia, lymphoma, Hodgkin’s disease and myeloma, and improves the quality of life of patients and their families. Providing free information and support services, Leukemia and Lymphoma funds lifesaving blood cancer research around the world. | LEUKEMIA & LYMPHOMA SOCIETY TAWANDA BRYANT 11410 COUNTY ROAD 20 BOLIGEE, AL 35443 (205) 336-9851
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