Alpha-1 Antitrypsin Deficiency rarely affects the skin, however approximately one in one thousand individuals with the most common type of severe deficiency are diagnosed with Panniculitis, which is the inflammation of the panniculus, the layer of fatty tissue below the skin, appearing as red spots that may give an oily discharge and may turn into ulcers with necrosis. Alpha-1 Antitrypsin Deficiency is caused by a mutation of the SERPINA1 gene that is responsible for synthesizing the protein. It
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Is the fact that around 40% of Americans are obese with that percentage growing by the year not enough motivation to make us try to solve the problem of obesity? This could be stopped more easily if it was stopped at the beginning; if we had less overweight children. Saying that the reason we, as a country, are unhealthy because of children that were born with too much baby fat is not true. Although, it is proven that children have an easier time losing and gaining weight which should be used to
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Introduction Multidrug resistance (MDR) is one of the major issues to be addressed in treating many diseases including cancers. One of the well-established causes for the multidrug resistance involves over expression of members of ATP binding cassette (ABC) proteins 1. The transporters play a key role in drug availability, metabolism and toxicity. Imatinib mesylate, a tyrosine kinase inhibitor, is a successful chemotherapeutic drug for the treatment of chronic myeloid leukemia (CML). However
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There has long been an ongoing debate about whether obesity is a choice or not a choice. Some may say that people can choose to be obese because, after all, a person chooses what and how much they eat. They also choose whether or not they exercise. Eating the wrong things and not exercising a lot is a cause of obesity. Others may argue that obesity is not a choice and that genetics play a major role in a person’s obesity. Genetics such as Leptin Resistance, Impaired Hunger-Hormones, Cushing’s Syndrome
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coronary artery disease, and atherosclerosis, which is stiffening and hardening of the artery walls. Obesity is the major cause of type 2 diabetes, and even though this begins in adulthood, this is now occurring in children due to the problem rising. Cancer is not exactly related to obesity, but is still a health effect since it is a mix of various diseases. Joint problems can also occur because obesity can affect the knees and hips by putting stress on the joints with extra weight. There are many
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Eureka! The cure for cancer has been found. The holy grail of modern medicine has been discovered. But there is one problem – it is locked up inside a top secret government facility restricted to the public. Why so? Because there is far more money to be made in treating a disease than curing it. Why cure someone of cancer in a day if they can be treated for it their entire life and bill them every step along the way? This is modern day society. It is the vivid reality of the dystopian world portrayed
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undergoing phase 1, 2, and 3 of preclinical trials and show encouraging results when coupled with chemotherapy. cite my group partners However, resistance to this targeted molecular therapy is proving to be a major hindrance in both drug development and cancer research. Although the previously discussed TKIs have not been approved for clinical use, several studies highlight the development of drug resistant mechanisms. Pharmodynamic modeling has identified two types of FLT3 mutations conferring resistance:
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What Is Radiesse? Hands have a tendency to age just like the rest of the body. In fact, hands have a tendency to age faster than the face. Many of us are very meticulous about caring for our face. We use cleansers, moisturizers and sunscreen on our face, but we often neglect our hands. Additionally, constantly washing the hands can cause them to age faster. Frequent handwashing can lead to hand dryness. The hands have a tendency to become less elastic and less toned as the result of aging. The
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Obesity: It is Not Just in the Head In the article, “Rethinking Weight,” author Amanda Spake claims obesity is not just an eating complication but a complication caused by the wrong genes and a bad mindset. Spake has compiled quotes and statistics of various doctors and geneticists that have to back her claim up. Spakes believes that just having an eating problem alone will not make you obese. Spakes shares from a geneticist that says that people are accused of becoming obese from a lack of
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Studies conducted on obese children found that the left ventricle size and mass along with left atrial measurements were considerably larger than those with a normal BMI. Left ventricular mass is found by accounting for body size, including both height and weight (Sorof and Daniels, 2002). Left ventricle mass is linked with more epicardial fat in obese children. Epicardial fat is adipose tissue found around the walls of the heart and the membrane surrounding the heart which is a risk factor for CVD
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