Free Essay

Acetaminophen Lab Report

In:

Submitted By relrod
Words 713
Pages 3
Randall Elrod
12/6/2013
Acetaminophen

Title
Acetaminophen
Purpose
To prepare acetaminophen.
Theory
Acetaminophen is a synthetic, nonopiate, centrally acting analgesic derived from p-aminophenol.1 The full chemical name is N-acetyl-p-aminophenol.1 The pKa of acetaminophen is 9.51 at 25°C.1 Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever.2 Acetaminophen may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).2 Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers).2 It works by changing the way the body senses pain and by cooling the body.2 Acetaminophen is one of the most commonly used medicines in the United States.3 When used according to the label directions, it has a well-established record of safety and efficacy.3 Although acetaminophen overdose is very rare in the context of its broad usage, overdose can be toxic and lead to acute liver failure.3 Preparation of acetaminophen involves treating an amine with an acid anhydride to form an amide.4 In this experiment, p-aminophenol (the amine) is treated with acetic anhydride to form acetaminophen (p-acetamidophenol), the amide. The chemical reaction for acetaminophen is as follows: 4

Procedure
Procedure is as taken from Pavia, Lampman, Kriz pages 43-44.4
The only deviation in this experiment was 0.67g of crude acetaminophen was used instead of 1g to recrystalize the sample because only 0.67g was produced during the production of acetaminophen.

Diagrams of equipment used:
Steam Bath

Gravity Filtration

Ice Bath

Vacuum Filtration

Table of Reagents
Reagent Structure Melting Point Boiling Point Density Solubility
(In water) p-Aminophenol 188 °C 284°C 1.29g/cm³ 1.5 g/100 mL (20 ºC)
Acetic Anhydride
-73.1 °C 140 °C 1.087g/mL REACTS with water
Acetaminophen
168-172 °C (lit.) No Boiling Point 1.293 g/cm³ 14 g/L (20 ºC)
Acetic acid
16.2 °C (lit.) 117-118 °C (lit.) 1.049 g/mL at 25 °C (lit.) Completely soluble with water *All data taken from Chemical Book Website5

Safety Precautions
Safety glasses are to be worn at all times and all chemical reactions were performed under vented hoods.

Observations
After adding Norite to the p-aminophenol and HCl solution the solution turned dark. After heating and filtering the color remained dark. After adding the buffer solution and acetic anhydride, the mixture was heated and then placed in an ice bath. Crystals were formed after approximately 15 minutes. Scratching the flask helped induce crystallization. The crystals were vacuum filtered, washed, and then dried for a week. The weight of the unpurified acetaminophen was 0.67g. After recrystallization and vacuum filtering, the purified sample weighed 0.08g and was lighter in color due to fewer impurities.

Results
Limiting Reagent and Theoretical Yield

The p-Aminophenol (C6H7NO) is the limiting reagent since it yields the least amount of Acetaminophen. 2.91g of C8H9NO2 is the theoretical yield.

% Yield

% Recovery of Recrystallization

Conclusion
The overall difficulty to this experiment was moderate. The only difficulty encountered was that the percent yield was low due to careless errors in the laboratory. These careless errors can be prevented in future experiments by using more precaution when weighing reagents and being more attentive when performing each step of the procedure.

References 1Remington's Pharmaceutical Sciences. 23rd ed. Easton, PA: Mack Publishing Company; 1995:1109-1110.
2"Acetaminophen: MedlinePlus Drug Information." U.S National Library of Medicine. U.S. National Library of Medicine, n.d. Web. 04 Dec. 2013. .
3"Drugs." Acetaminophen Toxicity. N.p., n.d. Web. 05 Dec. 2013. .
4Pavia; Lampman; Kriz, Introduction to Organic Laboratory Techniques Third Edition; Saunders College Publishing: 1988; pp 43-44.
5ChemicalBook---Chemical Search Engine. N.p., n.d. Web. 07 Oct. 2013. .

Questions

1.

2.
P-aminophenol has an alcohol functional group and since water has a lower pKa value than p-aminophenol, the p-aminophenol acts as the base and water as the acid.
Acetaminophen is an acidic drug, and is thus much less likely to ionize in aqueous solution.

3.

4.
Theoretical Yield

Similar Documents

Free Essay

Lab Report Instructions

...London School of Engineering and Materials Science Laboratory report writing instructions DEN101 - Fluid Mechanics 1 Flow Rate Measurement Experiment A. Student Student Number: 1234567 Version 2.0, 27 November 2010 Template for Word 97-2003 Abstract This document explains what is expected in your Fluids 1 lab report. The sections that should be covered are outlined and a structure you could follow is proposed. Detailed advice on how to edit the report is given. The document concludes with the marking criteria for this lab report. Table of Contents Abstract 2 1. Introduction 3 1.1. Writing 3 1.2. Editing and formatting 3 1.3. Content of the introduction 4 2. Background and theory 4 3. Apparatus 4 4. Test 4 5. Experimental procedure 4 6. Results 5 7. Discussion 5 8. Conclusions 5 9. References 5 10. Appendix A: Marking criteria 6 Introduction Before starting to write a report, you should think about what is your audience. Am I writing for colleagues who want a lot of detail how it is done, or am I writing for my boss who just wants an executive summary as he has no time for details? In general, there is not a single type of audience and we have to make our writing suitable for the detailed read, as well as the fast perusal. To understand what is required from you in this report, please have a look at the marking criteria in the Appendix. 1 Writing To limit...

Words: 2017 - Pages: 9

Premium Essay

Medication Reconciliation Case Study

...1. The nurse completes the medication reconciliation for this patient. Explain the information gained in this procedure and the purpose of the medication reconciliation. (5 points) The medication reconciliation presented a panoramic view of the dose, route and frequency of the prescription the patient is currently taking. After it is performed it can be observed that the patient is taking 1200mg of Ibuprofen which is the max dose per day. Tylenol is prescribed 500mg every 6 hours PRN, patient need to be instruct not to exceed 3000mg per day. It is important to teach patient about the possible interaction between NSAID or acetaminophen and OTC cold medication. Hydrochlorothiazine 25mg twice a day, diuretics need to be monitor due to the interaction...

Words: 2116 - Pages: 9

Premium Essay

Concept Mqp

... * Aortic Stenosis * Paroxysmal A-Fib * Metoprolol tartrate (lopressor) * Amlodipine (Norvasc) * Enalapril (Vasotec) * Furosemide (Lasix) * D: Decreased cardiac output related to inflammation of lining of the heart and valves. * I: Monitor for symptoms of heart failure and decreased cardiac output. Listen to heart sounds, lung sounds and note flowing symptoms: dyspnea, orthopnea, paroxysmal nocturnal dyspnea, Cheyne-Stokes respirations, fatigue, weakness, third and fourth heart sounds, and crackles in lungs. * D: Risk for infection due to previous diagnosis of endocarditis and recent surgery. * I: Observe and report signs of infection such as redness, warmth, discharge, and increased body temperature and white blood cells. Pain: * Acetaminophen (Tylenol) 650 mg * Oxycodone-acetaminophen (Percocet) 5-325 mg * D: Acute pain related to inflammation and surgery. * I: Conduct pain assessment using scale of 0-10 and implement pain management interventions. Circulatory: * Heparin (Porcine) 5,000 units * D: At risk for blood clots due to artificial valve, cardiac disorders, and lack of mobility due to activity intolerance related to reduced cardiac reserve. * I: Apply compression stockings and have patient use incentive spirometer. * D: At risk for bleeding due to anti-coagulants. * I: Monitor signs of bleeding in the urine, stool, sputum, and vomit. Medications * Metoprolol Tartrate (Lopressor) ...

Words: 963 - Pages: 4

Premium Essay

Gnt1, Genetic Counseling

...GNT1, Contemporary Nursing Issues, Task 1 Mrs. Elli Baker is a 73-year-old female who is transferred to the emergency room after collapsing in her backyard. Just prior to this, while talking to her friend on the phone, she seemed confused and beside herself. Upon arrival to the ER, she complains of some dyspnea with an increase in her respiratory rate and pulse. Her previous history includes diabetes and hypertension. She has recently started a new blood pressure medication: lisinopril. Her other medications include metformin and hydrochlorothiazide. The nurse is able to ask Mrs. Baker a few questions, but she then becomes unresponsive and has more difficult time breathing. As Mrs. Baker’s nurse, I would initiate a code immediately by dialing the operator using the phone in the patient’s room. The operator, in turn, calls a code over the hospital intercom system; thus, obtaining the assistance of several other staff members such as a respiratory therapist, the nursing supervisor, and an ICU (Intensive Care Unit) nurse. The respiratory therapist is expert in the field of lung function and responds to any codes or traumas within the hospital. The respiratory therapist participates in intubation of a patient, manages the bag/valve mask system for managing respirations in an intubated patient, performs tests such as ABG, and manages ventilation equipment when necessary. The Nursing Supervisor makes herself available to all nursing staff for support, acts as a script...

Words: 2364 - Pages: 10

Free Essay

Nurse

...Medication Sheet Medication/Dose/RouteClassificationGeneric/Trade Name | Action | ContraindicationAdverse Effects | Nursing Considerations | Acetaminophen/500mg/ By MouthAntipyretic& Analgesic (nonopioid)Acetaminophen/TylenolCarvedilol/6.25mg/By MouthAlpha- and beta-adrenergic blocker & AntihypertensiveCarvedilol/CoregDocusate Sodium/100mg/By MouthLaxative stool softenersDocusate Sodium/ColaceFurosemide/40mg/By MouthLoop diureticsFurosemide/Lasix | Reduces fever by acting directly on the hypothalamic heat-regulating center to cause vasodilation and sweating, which helps dissipate heat.Carvedilol causes vasodilation by blocking the activity of α-blockers, mainly at alpha-1 receptors. It exerts antihypertensive effect partly by reducing total peripheral resistance and vasodilation. It is used in patients with renal impairment, NIDDM or IDDM.Promotes incorporation of water into stool, resulting in softer fecal mass, may also promote electrolyte and water secretion into the colon. It increases the amount of water and fat absorbed by the feces, softening the stool and making it easier to pass.Inhibits the reabsorption of sodium and chloride from the loop of Henle and distal renal tubule. Increases renal excretion of water, sodium, chloride, magnesium, potassium, and calcium. | Contraindicated with allergy to acetaminophen. Use cautiously with impaired hepatic function, chronic alcoholism, pregnancy, lactation. Adverse effects CNS: Headache CV: Chest pain, dyspnea, myocardial...

Words: 2080 - Pages: 9

Free Essay

Doctor

...decompression for spinal stenosis in 2008. He lives with his wife of 51 years, Mrs. L, who cares for him. His biggest concerns are forgetfulness, difficulty walking and falling while his wife reports that he does “almost nothing” besides watching television and following her around the house. He requires considerable help with bathing and dressing, some assistance with toileting and transferring, and was dependent in most instrumental activities of daily living, including shopping, housekeeping and meal preparation. He reports no significant pain or discomfort relative to his back problems. They are able to afford a home health aide for several hours a day to help alleviate the burden of care for Mrs. L. At this visit the examination and subsequent labs reveals the following data: BP 130/65mm Hg Pulse 58 Hemoglobin A1C 5.9% Hemoglobin 13g/dl Estimated creatinine clearance via Cockcroft/Gault 42ml/min Folstein Mini-Mental State Examination (MMSE) 13/29 – consistent with moderately severe cognitive impairment Current Medications: Glyburide 2.5mg Q AM Digoxin .125mg Q AM Warfarin titrated to INR of 2-3 Celebrex 200mg QD Memantine 10mg BID Metoprolol 25mg BID Docusate sodium 100mg QD MVI QD Ferrous Sulfate 300mg QD Gabapentin 300mg BID Omeprazole OTC 20mg QD Acetaminophen 650mg q6h prn Lactulose prn Benadryl 25mg HS PRN Perform a Medication Regimen Review for this patient. Include all assumptions...

Words: 282 - Pages: 2

Free Essay

Pestel Analysis of Pharmaceutical Industry

...ToxicoL Copyright © 1983 1983. 23:87-101 by Annual Reviews Inc. All rights reserved THE TREATMENT OF ACETAMINOPHEN Annu. Rev. Pharmacol. Toxicol. 1983.23:87-101. Downloaded from www.annualreviews.org by Queen Mary & Westfield on 03/14/11. For personal use only. POISONING L. F. Prescott and J. A. J. H Critchley Regional Poisoning Treatment Centre, and University Department of Therapeutics and Clinical Pharmacology, The Royal Infirmary, Edinburgh, EH3 9YW, Scotland INTRODUCTION Acetaminophen (paracetamol, N-acetyl-p-aminophenol, 4-hydroxyacetani­ lide) is a non-prescription antipyretic analgesic that was first introduced into clinical medicine towards the end of the last century (1). It attracted little interest until it was found to be the major metabolite of both acetani­ lide and phenacetin (2, 3) and in recent years it has become an increasingly popular substitute for aspirin. Acetaminophen seemed to be remarkably safe when taken in recommended doses and formal toxicity studies were never carried out. In 1964 Eder (4) first reported liver damage in cats given 25-50 mglKg of acetaminophen daily for 26 weeks, and two years later Boyd & Bereczky described extensive hepatic necrosis in acute toxicity studies in rats (5). At the same time liver damage was first reported in man following acetaminophen overdosage (6, 7). The use of acetaminophen for self-poisoning has since increased dramatically in many countries and acute hepatic necrosis, sometimes fatal...

Words: 7818 - Pages: 32

Premium Essay

Copd Case Study

...Airway/Breathing (Oxygenation) Pneumonia/Chronic Obstructive Pulmonary Disease Clinical Reasoning Case Study STUDENT Worksheet JoAnn Walker, 84 years old Overview This case study incorporates a common presentation seen by the nurse in clinical practice: community acquired pneumonia with a history of COPD causing an acute exacerbation. Principles of spiritual care are also naturally situated in this scenario to provide rich discussion of “how to” practically incorporate this into the nurse’s practice. Concepts (in order of emphasis) I. Gas Exchange II. Infection III. Acid-Base Balance IV. Thermoregulation V. Clinical Judgment VI. Pain VII. Patient Education VIII. Communication IX. Collaboration I. Data Collection History of Present Problem: Pneumonia-COPD JoAnn Walker is an 84-year-old female who has had a productive cough of green phlegm 4 days ago that continues to persist. She was started 3 days ago on prednisone 60 mg po daily and azithromycin (Zithromax) 250 mg po x5 days by her clinic physician. Though she has had intermittent chills, she first noticed a fever last night of 102.0. She has had more difficulty breathing during the night and has been using her albuterol inhaler every 1-2 hours with no improvement. Therefore she called 9-1-1 and arrives at the emergency department (ED) by emergency medical services (EMS) where you are the nurse who will be responsible for her care. Personal/Social History: JoAnn was widowed...

Words: 2774 - Pages: 12

Free Essay

Jane Dare

...Instructions Complete the medical abbreviations chart. (Note that the medical abbreviations are the same as those highlighted in yellow in Jane Dare’s Health Record). In the second column, list what each of the individual letters in the abbreviation represents. In the third column define the context or meaning of the term that the abbreviation represents. Use simple terms. Finally, in the far right column, identify the source document. For example, face sheet, discharge summary, progress notes, or x-ray report. Abbreviation | Letters Represent | Context Definition or Application within the Patient’s Chart | Source Document | 1. ICD | International classification of disease | Jane dare’s disease | Admission summary | 2. CM | Cardiomyopathy | Structural or functional disease of heart muscle | Admission summary | 3. N/A | N- NotA- Applicable | Not availableNo answer | Admission summary | 4. ER | E-EmergencyR- Room | Arrived at emergency room | History and physical | 5. C/O | Complains of | Reason for Jane to go to the ER | History and physical | 6. SOB | Shortness of Breath | Having difficulty breathing | History & physical | 7. mg | Milligrams | 1/1000 of a gram | 25mg capoten orally 3x a day | 8. po | Peri/osteum | Takes furosemide 40mg orally daily | Medications/ history & physical | 9. tid | Times interval difference | 25mg capoten by mouth 3 times a day | medications | 10. qd | Quantum dot | MOM 30cc daily by mouth...

Words: 845 - Pages: 4

Free Essay

Dm Case Study

...Case Study Three CC: Jose Santa Cruz (JS) is a 68 y/o Native American male and retired construction worker. JS no longer works at this time, except to watch his grandchildren occasionally. ID: 68 y/o Native American Male, retired construction worker. CC: Rt knee pain x many years; epigastric burning with food x 2 weeks with dark stools. HPI: Pt c/o previous history rt knee pain for many years. He also c/o epigastric burning over past 2 weeks, and newly noted dark stools with no other prior history. Onset of rt knee pain approximately 7-8 years ago and increasing at this time. Epigastric burning onset is described as 2 weeks ago with dark stools noticed over past couple days. The location of his knee pain is centered over knee joint. Epigastric pain is focused in the mid to rt upper abd per Pt. Characteristics of his rt knee pain include occasional sharpness with an ongoing ache. His epigastric pain is characterized as burning which occasionally wakes him at night. He describes his stools over the past 1-2 days as dark-black in color, but not tarry in texture. JS denotes aggravating knee pain with movement especially getting up and down, or any activities which put pressure on his knee. He states his epigastric burning is aggravated by certain foods, especially high spice foods. His stools are recently dark- no aggravating of the color change noted. Relief of rt knee pain has been attempted with Advil 800mg po tid without good pain control. JS has also tried...

Words: 2163 - Pages: 9

Premium Essay

Competency Differences Between Adn and Bsn

...Competency Differences between Associate and Baccalaureate Nurses Scott Dickinson R.N. Grand Canyon University NRS-430 V May 12, 2012   Competency Differences between Associate and Baccalaureate Nurses Becoming a registered nurse involves attending college and graduating from either an Associate’s degree program, taking typically 3 years, or a Baccalaureate program, typically 4 years. Both degrees require the graduate to pass the NCLEX-RN exam. The percentage of nurses passing the NCLEX-RN is statistically insignificant regardless of program type- associates vs. baccalaureate. The NCLEX-RN exam tests for the minimal amount of skills the individual must have for safe practice. It does not measure, nor represent, the additional education a baccalaureate nurse will have obtained (2008). Baccalaureate graduates do excel in stronger communication skills, and have shown greater problem solving skills (Johnson, 1988). Additionally, the baccalaureate nurse shows greater nursing diagnosis skills and implementation of appropriate nursing interventions (Giger, 1990). Dr. Patricia Benner & team- Carnegie Foundation for the Advancement of Teaching , suggests the requirement of all entry level registered nurses (associate degree) become baccalaureate trained, additionally, that within 10 years of any nurses primary licensure (associate or baccalaureate) that the education level of masters be obtained. The purposes of these proposals are to have better educated nurses as many...

Words: 1126 - Pages: 5

Premium Essay

Mock Code

...History: Married with two adult children who live locally; Does not smoke, drink or use illicit drugs Handoff Report Situation: The patient is a 60-year-old male in room 425 on the Orthopedic Unit who is recovering from an anterior-posterior interbody fusion of L4 – L5 performed two days ago. His has had an uneventful recovery. He is in his room eating breakfast. Background: Hypertension, hypercholesterolemia and obesity. The hypertension has been well controlled by his medication. He is wearing a soft neck collar for support following a minor car accident three weeks ago in which he sustained whiplash. The patient has no known drug allergies and is awake and alert. Assessment: Vital signs: HR 87, BP 128/62, RR 18, SpO2 has been 98% on room air, Temp 37.1oC Cardiovascular: No telemetry; HR regular Respiratory: Clear in both lung fields GI: Advanced to full liquid diet and tolerating it well GU: Voiding clear, yellow urine Extremities: Pink, warm and with adequate turgor; Movement is strong in all four extremities (4+) Skin: Warm and dry; No signs of infection at his surgical site Neurological: Alert and oriented to person, place and time; pupils equal, round, reactive to light and accommodation; no neurological deficits IVs: No IV access; saline lock became dislodged during the night and was not restarted as he will be discharged soon Labs: No labs ordered Fall Risk: Low-risk Pain: Well controlled Recommendations: Provide a complete...

Words: 1175 - Pages: 5

Premium Essay

Rheumatoid Arthritis Summary

...are legally accountable for their practice and must have a working knowledge of all the medications being given to their patients. Using the 12 rights of medication administration will ensure the nurse is following safe practice. When implementing the interventions for the nursing diagnosis for RA, the nurse must consider the following: For pain the nurse must not location and intensity using a scale of 0-10. The nurse must consider what precipitated the pain and also watch for nonverbal indications of pain. To help with pain relief the nurse should pre-medicate before activities if possible. All of the medications discussed in this paper can help relieve pain. Prednisone and the DMARDs help with pain caused by inflammation, and acetaminophen relieves the pain still experienced. For impaired physical mobility the nurse wants to assess joint inflammation and pain. The client’s level of activity highly depends on the inflammatory process. Once again, all of the medications discussed in this paper can help the patient achieve the wanted outcomes of drug therapy. All the medications help with inflammation, that can cause limited ROM, or...

Words: 2023 - Pages: 9

Premium Essay

Skill Validation

...manually. With manual transitions, the instructor should advance to the applicable state when appropriate interventions are performed. Initially, in State 1 0900 Hours Assessment, the learner is presented with a patient who is febrile and exhibiting other signs of infection. Initial assessment reveals a temperature of 38.6o Celsius, HR in the 80s, BP in the 140s/80s, RR in the low 20s and SpO2 in the mid 90s on room air. Breath sounds demonstrate crackles bilaterally. The patient is anxious and incontinent of urine. She has a non-productive cough and reports tenderness over the left ankle. Initial treatment includes application of an elastic bandage to the left ankle, assessment of pain level, administration of pain medications, insertion of a urinary catheter and a sterile wet-to-moist dressing change to the graft site. If learners request results of blood glucose, the facilitator should role-play the laboratory technician and report that admission blood glucose was 105. Two hours post admission at 1100, patient complains of “throbbing” pain at the graft site. She rates the pain 6/10. If learners request results of a chest x-ray, it shows right lower lobe pneumonia. The learner is expected to notify the healthcare provider of the...

Words: 4609 - Pages: 19

Premium Essay

Headache Research Paper

...within, acute stress of living, poor working condition, extreme anxiety and fear, financial instability may cause the primary types of headaches. It is due to muscle contraction in the head, neck, shoulders and face. They are typically linked to stress, fatigue, emotional conflicts, depression or repressed hostility. The most common sources of stress relates to family, social relationships, close friends, work condition and school environments. Headache can last from 30 minutes to an entire week. Nearly 90% of women and about 70% of men experience it at some point. They are easily treated with over-the-counter (OTC) medications, including aspirin. If the frequency is more than 15 days a month, then they are considered as chronic and needs lab tests and suitable treatment for the underlying conditions. When acute treatment is needed, non-steroidal anti-inflammatory drugs such as aspirin may be effective. However, chronic tensions and occasional serious tension-type headaches that do not respond to OTC may require treatment with prescription medications. Regular lifestyle habits like quit smoking, reduced stress, getting enough sleep, eating a healthy diet, and having a regular exercise, all help to reduce tension-type headache risk. Cluster headache happens rarely to less than 1% of the population. The unique feature of cluster headache is that the attack occurs in cyclical patterns, or in clusters – which give the condition its name. The period generally lasts from 1 to 12 weeks...

Words: 2195 - Pages: 9