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Alzheimer's Disease: A Case Study

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Alzheimer’s disease is an organic brain disorder that causes dementia by systematically damaging the brain tissue. It is progressive, unrelenting, and irreversible, and it affects more than 5 million Americans today, most of whom are older than age 60. Recent estimates rank Alzheimer’s disease as the third leading cause of death in the United States in the geriatric population (NIA). It has been long known that altered sleep patterns often accompany the progression of Alzheimer’s disease, but recent research is questioning just what the link between the two may be. Alzheimer’s disease is characterized by a build-up of toxins in the brain, namely amyloid plaques and neurofibrillary tangles. While there is some build-up of amyloid plaques …show more content…
In 2013, researchers at the University of Rochester Medical Center demonstrated that, contrary to prior belief, the brain does, in fact, have a system to cleanse and remove waste products, similar to the function of the lymphatic system in the rest of the body. Researchers dubbed this mechanism the “glymphatic system” as it is regulated by the glial cells of the central nervous system. The really amazing thing about this mechanism in relation to Alzheimer’s disease is that the glymphatic system only works while we are in a deep sleep. The brains of the animal test subjects were able to clear beta-amyloid twice as quickly when asleep as compared to a waking state (NIH). The relationship between Alzheimer’s disease and sleep disturbances would seem, then, to have a bi-modal link. The initial lack of deep sleep leads to a build-up of beta-amyloid. Beta-amyloid is the precursor to amyloid plaque deposits in the brain. Amyloid plaques in the brain cause damage and destruction in the brain regions that regulate sleep, which leads to an increase in sleep disturbances (JAMA). It would seem, then, that if medical intervention could increase the quality of sleep in people with pre-clinical Alzheimer’s disease, the onset of overt disease could be delayed or even prevented all

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