...REGULACIJA MIKROOKOLJA METASTAZ MATEJA ZVER, 4. letnik kemije, smer biokemija in fizikalna kemija, študijsko leto 2010/2011 KAZALO METASTAZE INTERAKCIJE MED TUMORJEM IN STROMO NA PRIMARNEM MESTU ZDRAVO TKIVO V TELESU VLOGA STROMALNIH CELIC ZA RAZVOJ TUMORJEV KRONIČNO VNETJE IN VLOGA BMDC MAKROFAGI POVEZANI S TUMORJI MIKROOKOLJE METASTAZNIH MEST VLOGA PROTEAZ ZAKLJUČEK LITERATURA 3 3 3 3 4 4 5 6 6 8 2 METASTAZE Metastaze so večstopenjski proces, pri katerem rakave celice pobegnejo od primarnega tumorja, preživijo v obtoku ter se razširjajo na oddaljena mesta in rastejo. Vsaka od teh stopenj vsebuje korak, na katerega vplivajo zdrave celice mikrookolja tumorja. V članku opisujejo vlogo mikrookolja v metastazah, identificira območja za nadaljne raziskave ter predlaga nova možna področja zdravljenja. Različne stromalne celice v okolju so potrebne za pospeševanje rasti raka ter lažje razširjanje metastaz do drugih organov. Rakave celice spretno izkoriščajo predvsem mikrookolje tkiv. Vendar, ko le – te zapustijo ugodne pogoje za rast, morajo imeti lastnosti, ki jim bodo omogočale preživetje v novem okolju. Da se metastaze sploh pojavijo, morajo rakave celice preživeti v obtoku, prispeti morajo do tarčnega organa in pokazati stalno rast. Vsaka od stopenj je ali nepomembna...
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...Introduction “Good customer service is the lifeblood of any business. You can offer promotions and slash prices to bring in as many new customers as you want, but unless you can get some of those customers to come back, your business won’t be profitable for long.” (As cited in Customer Service – 8 Rules For Good Customer Service 2009.) Excellent customer service is one of the key necessities that a business must have to run a successful enterprise. Businesses in today’s world are changing, especially in the marketing department. Weather the business is a large one, for example Wall Mart or just small local businesses that are family owned and operated, such as Wayne’s Drive Inn. The main point of any business is to focus on what the customers need is and to make sure they are satisfied with the quality of service that the business is providing. Businesses need to provide their employees on the front line with proper training, which means those employees that have contact and interact with customers on daily basis’s, weather face to face or verbally must be able to offer the amount of service required. Training is also important for business’s employees because those are the people your customers deal with, and also those employees are the face of the business. Therefore a businesses selection of employees can either make or break ones business. “Well, the Harvard Business Review reports that if you can prevent 5% of your customers from leaving you, you can increase yourbottom...
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...LIBERTY UNIVERSITY THEOLOGICAL SEMINARY The Life of Michael Servetus A Research Paper A Paper Submitted to Dr. Jerry Sutton In Partial Fulfillments Of The Requirements For The Course CHHI-525 History of The Christian Church II BY Andrea Gearing Cumming, Georgia August 17, 2012 CONTENTS INTRODUCTION--------------------------------------------------------------------------------3 MICHAEL SERVETUS EARLY LIFE-------------------------------------------------------3 BRIEF SUMMARY OF MICHAEL SERVETUS WORKS-------------------------------6 THE TRINITY AND MODERN SCHOLARSHIP-----------------------------------------9 MICHAEL SERVETUS THEOLOGY------------------------------------------------------10 CONCLUSION---------------------------------------------------------------------------------14 BIBLIOGRAPHY------------------------------------------------------------------------------17 INTRODUCTION The first time I was introduced to Michael Servetus, I was a student at Liberty University. I had never heard of this important figure in History. At any rate, I had begun to find ways to learn more about him. It was on a Wednesday night, one week before the night of my church Bible study that I had to submit a discussion board question of Michael Servetus in church history. I arrived at Bible study with Michael Servetus in my spirit. When I arrived at church my pastors opening statement was: "In 1553, Michael Servetus was burned at the stake for what I am going to...
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...Introduction Banana (Musaspp.) is the fourth most important global food commodity after rice, wheat and maize in terms of gross value production. At present, it is grown in more than 120 countries throughout tropical and subtropical regions and it is the staple food for more than400 million people (Molina and Valmayor, 1999). Among the production constraints, Fusarium wilt caused by the fungus Fusarium oxysporum f.sp cubense(Foc) is the most devastating disease affecting commercial and subsistence of banana production through out the banana producing areas of the world (Ploetz, 2005). The disease is ranked as one of the top 6 important plant diseases in the world (Ploetz & Pegg, 1997). In terms of crop destruction, it ranks with the few most devastating diseases such as wheat rust and potato blight (Carefoot andsprott, 1969). The disease almost destroyed the banana export industry, built on the Gros Michel variety, in Central America during the 1950’s (Stover, 1962). In addition, the widely grown clones in the ABB ‘Bluggoe’ and AAA ‘Gros Michel and Cavendish’ sub groups are also highly susceptible to this disease worldwide. Presently, Fusarium wilt has been reported in all banana growing regions of the world (Asia, Africa, Australia and the tropical Americas) except some islands in the South Pacific, the Mediterranean, Melanesia,and Somalia (Stover, 1962; Anonymous, 1977; Ploetz and Pegg, 2000). The fungus Focis the soilborne hyphomycete and is one of more than 100 formae...
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...Quarter 2 (7th)‐ “Melting Pot” and “How I Learned English” Stage 1 – Desired Results Standards LRA 3.2 (Fall EOC) Identify events that advance the plot, and determine how each event explains past or present actions or foreshadows future actions. ARG LRA 3.4 (Fall EOC) Identify and analyze recurring themes across works (e.g. the value of bravery, loyalty, and friendships; the effects of loneliness). ARG V1.1 (Fall EOC) Identify idioms, analogies, metaphors, and similes in prose and poetry. V 1.3 (Fall EOC) Clarify word meanings through the use of definition, example, restatement or contrast. WA 2.5‐ (STAR) Write summaries of reading materials. SUM WA 2.2 (On Demand/ STAR) Write Responses to Literature. ARG WS 1.2 (On Demand) Support all statements and claims with anecdotes, descriptions, facts and statistics, and give examples. REF WS 1.3 Use strategies of note‐taking, outlining and summarizing to impose structure on composition drafts. AN, SUM, REF WS 1.4 (Fall EOC) Identify topics and evaluate questions and develop ideas leading to inquiry, investigation, and research. AN, ARG WS 1.7 (On Demand, Fall EOC) Revise writing to improve organization and word choice after checking the logic of ideas and the precision of vocabulary. ALANG WOC 1.4 (On Demand) Demonstrate the mechanics of writing (e.g. quotation marks, commas at the end of dependent clauses) and appropriate English usage (e.g. pronoun reference). ALANG Big Ideas & Understanding(s): ...
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...___________ __ __ \_ _____/|__| ____ _____ | | | __) | |/ \\__ \ | | | \ | | | \/ __ \| |__ \___ / |__|___| (____ /____/ \/ \/ \/ ___________ __ \_ _____/____ _____/ |______ _________ __ | __) \__ \ / \ __\__ \ / ___< | | | \ / __ \| | \ | / __ \_\___ \ \___ | \___ / (____ /___| /__| (____ /____ >/ ____| \/ \/ \/ \/ \/ \/ ________________ |_ __ _ _ _| \ \/ / | | | | __\ /__| |_| |_ |________________| ____________________________________________________________________________ |~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~| | Author: A I e x ...
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