...Section 3 T.A. - Sheree Speckman November 15, 2011 Introduction: Cystic Fibrosis is one of the most common chronic lung diseases in children and young adults. It is an inherited deadly disorder that affects Caucasians in the United States. Cystic fibrosis of CF is a disease that is caused by a defected gene, which causes the lungs to build up with an abnormally thick and sticky fluid, or mucus. This mucus affects the lungs obstructing breathing along with also affecting the pancreas, causing poor absorption of nutrients. For my family Cystic Fibrosis is a well-known disease, because my Aunt Rae Ellen died of it back in 1962. The history of Cystic Fibrosis dates back into the mid-17th century where it was first known as a child who had become bewitched. Advances in cystic fibrosis began to pick up in the 1940s. Children with CF are normally diagnosed by the age of 2 and now can live to around the age of 40. There are many different symptoms that come along with this disease. There are different symptoms related to newborns, bowel functions, lungs, and later in life. The most common symptoms seem to be coughing or increased mucus in the lungs and salty-tasting skin. People with cystic fibrosis have mutations on the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which reduces the ability of chloride ions to travel across cell membranes. There is no way to prevent Cystic Fibrosis but there are ways to deal with it and have a quality life with it....
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...Cystic Fibrosis is a disease that for which one in every 25 Americans carry a gene, which means around 12 million Americans are carriers. It is caused by a mutation in the Cystic Fibrosis Transmembrane Conductance Regulator, causing an abnormal amount of mucus to be secreted, settling the lungs and pancreas. The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a protein that allows for chlorine ions to be able to escape mucus-producing cells. It helps thin out the mucus to keep the airways clear. When that gene is altered, it causes life-threatening harm to newborn babies, where most of them wouldn’t last longer than a couple of months. Due to the benefits of modern diagnosis and treatment, the life-span of a Cystic Fibrosis affected...
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...Cystic Fibrosis Imagine if you had a friend her name is Elyse Veldman and she has Cystic Fibrosis. Elyse has to deal with all of the struggles and difficulties that come with Cystic Fibrosis. Elyse and her family have known that she has CF ever since she was born. Elyse, crazy enough, was the first newborn in that hospital to be scanned for Cystic Fibrosis. Elyse is now 8 years old and has never had to take a trip to the emergency room involving CF. This is because Elyse’s parents always make sure that Elyse always takes her medication. You have known Elyse since you were a child and as you age you have a better understanding of what this crazy disease was doing to Elyse’s body but you still are not exactly sure about everything about CF. You know that Elyse Veldman is an incredible person with an hilarious personality and a big heart. What is...
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...How many of you have ever heard of the disease called Cystic Fibrosis? Im going to talk about how someone can get Cystic Fibrosis, some symptoms that go along with the disease, a few treatments, and the basic overall prognosis. Now I personally know a great deal about Cystic Fibrosis, or Cf as it can be called because 3 of my cousins actually have it. Cystic Fibrosis is a genetic disease. People inherit CF from their parents through genes, same as how you get your hair color, eye color and height. In order for a person to get CF they must inherit to copies ,one from each parent , of the defective gene called the CFTR gene. Now this gene cause the body to produce unusually , thick and sticky mucus. This mucus clogs the lungs and can cause life-threatening lung infections.It also obstructs the pancreas and stops natural enzymes from helping the body breakdown and absorb food. Some symptoms that go along with CF is Persistent coughingFrequent lung infectionsWheezing or shortness of breathPoor growth and weight gain despite having a good apetite Now even though CF is fairly a rare disease every newborn is screened for it. Now this is not entirely a definitve, so a follow up test is performed called the sweat test. This test measures the salt content of sweat. High salt= cf positive. Unfortuntley, there is no cure for Cystic Fibrosis. According to the CF Foundation Patient Registry the average life expectancy is 40 years old. This is still very young but the life expectancy...
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...According to the Cystic Fibrosis Foundation, cystic fibrosis (CF) is a fairly uncommon genetic disorder which occurs in approximately 70,000 people worldwide (n.d.-a). Although it is uncommon, the disease is fairly well known even in the general public. With advances in medicine, in both diagnosis and treatment of the disease, CF does not carry the death sentence it once did. As is the case with many diseases, people affected are living longer and more normal lives than they were able to in the past. Cystic fibrosis is a genetic disease which affects the mucous membranes as well as the sweat glands (Medline Plus, 2017). Cystic fibrosis is considered an autosomal recessive disorder, meaning that the child must inherit a faulty gene from...
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...Cystic Fibrosis is “the most common genetic condition in North America” (How Stuff Works Contributors) and even more prevalent in the UK. “Approximately one in 29 Americans are carriers to Cystic Fibrosis and the condition occurs in approximately one in 3,000 live births in America.” (How Stuff Works Contributors) Cystic Fibrosis is caused by a defective recessive gene, the cystic fibrosis transmembrane conductance regulator(CFTR), carried by both parents and passed on to their offspring. It has varying degrees of severity and tends to get worse with age. Diagnosis of Cystic Fibrosis is usually caught in very early infancy or childhood. “Every state in the U.S. now routinely screens newborns for cystic fibrosis.” (Mayo Clinic Staff) The test...
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...Cystic Fibrosis Cystic Fibrosis is an inherited lifelong disease that affects more than 30,000 children and young adults in the United States (Kids Health, 2007).This genetic disease which affects the transportation and clearance of electrolytes and fluids across cell membranes from exocrine glands (Yourlunghealth.org, 2004). Exocrine glands are present everywhere in your body that comes into contact with an external environment. There is no cure for cystic fibrosis (Medline Plus, 2009). Cystic Fibrosis affects the lungs, pancreas, digestive tract and reproductive tract (American Lung Association, 2008). Cystic fibrosis mainly affects the lungs and pancreas. It causes the lungs to create thick, sticky mucus blocks in the airway making it very hard for the child to breath and also very easy for them to get infections. This can lead to tissue damage and airway inflammation (Yourlunghealth.org, 2004).Eventually the chest will assume a barrel shape with increase in size in the front and back of the child (Price and Gwin, 2008).In the pancreas mucus blocks prevent enzymes that help to break down food from reaching the intestines and aiding in digestion(Genetics Home Reference, 2009).Since the digestive tract cannot digest food properly this can lead to many problems, such as poor absorption of vitamins and minerals which can ultimately lead to malnutrition (Yourlunghealth.org, 2004). Kids with cystic fibrosis have trouble gaining weight even when they have a normal diet and a healthy...
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...Cystic Fibrosis is a life-threatening disease that affects the organs such as the lungs, pancreas, intestines, and liver. The genetic disease also imbalances the body’s salt causing thick mucus to collect in the lungs, affecting the patients’ breathing and leading to several infections. Although cystic fibrosis can be fatal, many have patients lived up to an average of thirty-five years old. Since many individuals are affected by this disease, it is essential for people to understand it. Through the research of Cystic Fibrosis, doctors can learn the origin of the disease, the diagnosis, symptoms, and treatments. Cystic Fibrosis is an autosomal recessive disease that originated from European ancestry, and about 1,000 people are diagnosed with it every year (Mateu 3). The chronic disease is inherited from the parent’s cystic fibrosis transmembrane conductance regulator (CFTR) gene. The gene makes a certain protein that maintains the movement of water and salt throughout the body’s cells. If the parent’s gene is defective, that could either mean that the child will be a carrier or a victim. A carrier is one who does not show any symptoms of the disease but can pass their faulty gene onto their descendents. There are several different tests that can be performed to diagnose a person with Cystic...
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...BI 112 Genetic Paper Cystic Fibrosis Cystic fibrosis is a disease that can be genetically passed down to offspring. According to the cystic fibrosis foundation’s website, “it affects the lungs and digestive system of about 30,000 children and adults in the United States,” and “70,000 worldwide” (www.cff.org). The online website lab tests online, records that cystic fibrosis “is a relatively common disease caused by mutations in the gene located on chromosome 7” (www.labtestsonline.org). This chromosome contains a protein called cystic fibrosis transmembrane regulator or CFTR and a mutation in this gene “lead to absent or defective CFTR production causing cystic fibrosis (www.labtestsonline.org). There are some very specific signs and symptoms of this disease. Some of the most common symptoms are: “very salty tasting skin, persistent coughing at times with phlegm, frequent lung infections, wheezing or shortness of breath, poor growth/weight gain in spite of a good appetite, and frequent bulky tools or difficulty in bowel movements” (www.cff.org). It is also reported by the American lung association’s website that it “causes thick, sticky mucus to form in the lungs, pancreas and other organs. In the lungs, this mucus blocks the airways, causing lung damage and making it hard to breathe. In the pancreas, it clogs the pathways leading to the digestive system, interfering with proper digestion” (www.lungusa.org). It is important to be genetically tested to see if there...
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...“Cystic Fibrosis” Pediatric Case Study March 27, 2013 Kasie Wilson The name cystic fibrosis refers to the characteristic scarring (fibrosis) and cyst formation within the pancreas, first recognized in the 1930s. Cystic fibrosis (CF) is a major cause of serious chronic lung disease in children. It is an inherited recessive trait, in which both parents carry a gene for the disease. Children with cystic fibrosis have a defect in chromosome number seven, which is thought to have developed many years ago as a protective response of the human body against cholera (just a theory). The disease causes thick, sticky mucus to build up in the lungs, digestive tract, and other areas of the body such as the pancreas, liver, and intestine. It also causes a loss of electrolytes in sweat because of an abnormal chloride movement. About one thousand new cases of cystic fibrosis are diagnosed each year and more than seventy percent of these patients are diagnosed by the age of two. Cystic fibrosis is considered a multisystem disease because of the following effects of the thick, viscid secretions. In the respiratory system, small and large airways are obstructed, which then results in difficulty breathing. The accumulation and stasis of the secretions create a medium of growth for organisms that will cause repeated respiratory infections. The thick secretions in the lungs and response of tissues to infections cause hypoxia that can lead to heart...
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...Cystic Fibrosis (CF) is an additional genetic disorder that can cause several implications to a patient. Cystic Fibrosis is the most prominent single- gene genetic disorder. An individual inherits the disease through a combination of both parents having the CF gene in their genetic make up. Cystic Fibrosis is a disease that mainly affects the digestive system and lungs of a carrier. The defective gene causes the body to produce “a thick, sticky buildup of mucus in the lungs, pancreas and other organs.” This effect leads to a pathway of multiple complications for carriers of the defective gene. The genetic disease is most circulated in the caucasian population.(Nordhaus 117) Prominently, Caucasians carry the gene of Cystic Fibrosis. About...
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...Matto Massaad 1/19/16 AP Bio Mr. Duehr Cystic Fibrosis In 2010, two sisters, diagnosed with cystic fibrosis, went on America’s Got Talent to show the world that they would not let this horrible disease drag them down. People said from the start, according to Christina and Ali, “they would never be able to sing.” They were from a family of four children who were all diagnosed with cystic fibrosis. Cystic fibrosis is a single gene disorder. This disease is still very life threatening even though science, medicine, and technology have come a long way since the mid 20th century. In the past fifty years, cystic fibrosis patients have gone from dying as infants to having their average life expectancy be from 3540 years old, (Kaneshiro.) Cystic fibrosis is caused by a mutation of the CFTR gene. This gene makes a protein called CFTR or (cystic fibrosis transmembrane regulator.) This protein balances the salt and water content on epithelial surfaces by providing a channel for the movement of chloride ions in and out of cells, (Genetics and Nutrition.) The CFTR protein can be altered if there is a fatal mutation in the CF gene. Although there are so many different mutations of this gene, the most common is found in almost ninety percent of all cystic fibrosis patients. This mutation is just a simple deletion of three nucleotides. These three nucleotides were to create the amino acid phenylalanine, but with CF, that is never made. The CF protein never makes it to the cell ...
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...According to Marfan foundation, Marfan syndrome “is a genetic disorder that affects the body’s connective tissue. Connective tissue holds all the body’s cells, organs and tissue together. It also plays an important role in helping the body grows and develops properly.” The connective tissue is made up of proteins. The protein of the tissue is called fibrillin-1. It is found in 1 out of 1,500 people. It can be found in male and female and in all races. It is in inheritable 3 out of 4 people inherit Marfan syndrome. Cystic Fibrosis is because of a defective gene that causes a thick, buildup of mucus in the lungs, pancreas and other organs. In...
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...Greetings! What will YOU make possible? It is a question we can all ask ourselves. We taking on a huge challenge with the Children’s Tumor Foundation and making it possible to end neurofibromatosis (NF) through research. A very special little boy from Burleson is the reason we are doing this. My son, Denver Wakin is 9 years old and lives with NF every day. NF causes tumors to grow on nerves throughout the body and can lead to blindness, bone abnormalities, cancer, deafness, disfigurement, learning disabilities, and excruciating and disabling pain. NF is under-recognized and underdiagnosed yet affects more people than cystic fibrosis, muscular dystrophy and Huntington’s disease combined. CTF is at the forefront of funding critical NF research - research that is also shedding new light on several forms of cancer, brain tumors and other health issues, ultimately benefiting the broader community. This June we are hosting the 3rd annual TEAM DENVER Golf Tournament. In past years, our tournaments have been hugely successful and praised among our participants. The past two years we have raised over $30,000 and I truly hope that we can make our goal of $25,000 this year! I want to tell you how much we appreciate you being in the community and we would love to partner with you. We want our golfers to see the importance of our cause, of course - but also the importance of community. Together we can highlight to the people in the Dallas Fort Worth area how much you care...
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...Cystic Fibrosis Cystic Fibrosis (CF) is a life threatening disorder that causes severe damage to lungs and digestive system. CF affects the cells that produce mucus, sweat and digestive juices. These secreted fluids are normally thin and slippery but, in CF a defective gene causes the secretions to become thick and sticky. Instead of acting as a lubricant the secretions plug up tubes, ducts and passage ways especially in lungs and pancreas. CF is most common in white people of Northern European ancestry, but also occur in Hispanics, African Americans, and some Native Americans. (Mayo Clinic). More than 70% of patients are diagnosed by age two. The predicted median age of survival for persons with CF is in late 30’s. Symptoms of CF can be found in many ways, from very salty- tasting skin, persistant coughing at times with phlegm, frequent lung infections, wheezing, or shortness of breath, poor growth or weight gain in spite of good appetite, or frequent greasy, bulky stools or difficulty in bowl movements. Although CF requires daily care most people with condition of CF are able to attend school and work. (CFF2013) CF is diagnosed by many ways, all states screen newborns for CF using genetic testing or blood test. The blood test shows whether a newborns pancreas is working properly. Another way is sweat test, this test is most useful for diagnosing CF, a sweat test measures amount of salt in sweat. Doctors triggers sweating on small patch of skin on an arm or leg, he or she...
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