...Introduction Drug development from initial discovery of a promising target to the final medication, is characterized by a high degree of scientific, regulatory and economic risk. Colossal amounts of time, effort, and money are invested in the research and development process to bring a new medicine to the market. In fact, it takes an average of 10 to 15 years to bring a drug from discovery to approval, and for every 5,000-10,000 compounds investigated; only one is approved and marketed. Figure 1: Current time-scale of drug approval processes. Studies have estimated that the cost of bringing a single new drug to market is in excess of US $800million., Other health economists estimate that the current cost of drug development is now between US$1.3 billion to $1.7 billion., However, an updated cost per NCE (New chemical entity) has been recently calculated taking annual inflation, toughening regulatory demands and the decline in success rates into account. It has been proposed that the earlier cost estimate of drug development of $802M has risen to the astronomical level of $3.9Bn after adjustment. In addition, it is important to note that this does not represent the entire cost as the expenditure for marketing is omitted from these figures. However, the costs have been questioned as it is claimed it is in the best interests of drug companies to overstate costs since they often lobby governments to loosen price regulations and increase patent protection. The surging...
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...Nursing Leadership and Education Saturday, December 23, 2006 ADN vs. BSN Education Nursing education is bound by its contract with society to prepare nurses with the knowledge; skills and values that enable them to provide quality care within the contemporary health care system. Implicit in this process is that a layperson will be transformed into a competent professional (Lindeman, 2000). When addressed to nurses, the question of educational preparation into professional nursing practice has long been a source of frustration. This is not limited to educators; it is pervasive among all settings and at all levels of nursing practice. Societal changes, increased technology, the shortage of registered nurses (RN’s), and most notably, the increasing shift of health care from acute to community-based settings, has led nursing leaders to raise questions about past and future trends in nursing education (Speziale & Jacobson, 2003). Although associate degree nursing (ADN) education remains a viable choice for those wanting to enter the nursing profession, the ability of these programs to appropriately prepare students for the level of practice diversity that is inherent in the current system must be assessed, and their role defined with regard to the future. In thinking about this question about entry into practice, I had to do some reflection. As I come from an AD program, I have to say that for the time (graduated 1986), and for the expectations of entry-level...
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...A Practical Guide to Linux Commands, Editors, and Shell Programming SECOND EDITION ® Mark G. Sobell Upper Saddle River, NJ • Boston • Indianapolis • San Francisco New York • Toronto • Montreal • London • Munich • Paris • Madrid Capetown • Sydney • Tokyo • Singapore • Mexico City Many of the designations used by manufacturers and sellers to distinguish their products are claimed as trademarks. Where those designations appear in this book, and the publisher was aware of a trademark claim, the designations have been printed with initial capital letters or in all capitals. The author and publisher have taken care in the preparation of this book, but make no expressed or implied warranty of any kind and assume no responsibility for errors or omissions. No liability is assumed for incidental or consequential damages in connection with or arising out of the use of the information or programs contained herein. The publisher offers excellent discounts on this book when ordered in quantity for bulk purchases or special sales, which may include electronic versions and/or custom covers and content particular to your business, training goals, marketing focus, and branding interests. For more information, please contact: U.S. Corporate and Government Sales (800) 382-3419 corpsales@pearsontechgroup.com For sales outside the United States, please contact: International Sales international@pearson.com Visit us on the Web: informit.com/ph Library of Congress Cataloging-in-Publication...
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...SCHAUM'S OUTLINE OF THEORY AND PROBLEMS OF COLLEGE PHYSICS Ninth Edition . FREDERICK J. BUECHE, Ph.D. Distinguished Professor at Large University of Dayton EUGENE HECHT, Ph.D. Professor of Physics Adelphi University . SCHAUM'S OUTLINE SERIES McGRAW-HILL New York St. Louis San Francisco Auckland Bogota Caracas Lisbon London Madrid Mexico City Milan Montreal New Delhi San Juan Singapore Sydney Tokyo Toronto McGraw-Hill abc Copyright © 1997, 1989, 1979, 1961, 1942, 1940, 1939, 1936 by The McGraw-Hill Companies, Inc All rights reserved. Manufactured in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher. 0-07-1367497 The material in this eBook also appears in the print version of this title: 0-07-008941-8. All trademarks are trademarks of their respective owners. Rather than put a trademark symbol after every occurrence of a trademarked name, we use names in an editorial fashion only, and to the benefit of the trademark owner, with no intention of infringement of the trademark. Where such designations appear in this book, they have been printed with initial caps. McGraw-Hill eBooks are available at special quantity discounts to use as premiums and sales promotions, or for use in corporate training programs. For more...
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