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Disorders of the Brain: Mood Disorder

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Disorders of the brain: Mood disorder
Tanya Horton
Kaplan University
PS 124

Mood Disorder
The mental disorder that I have chosen to write about is a rather vague area, being mood disorders, that affects “nearly one in ten people aged 18 and older” (MedlinePlus, 2014). Mood disorders “are known to be at least impart genetic, because they are heritable” (Stangor, 2010,. p. 379). “A mood disorder is diagnosed when sadness or elation is overly intense and persistent, is accompanied by a requisite number of other mood disorder symptoms, and significantly impairs the person's capacity to function” (The Merck Manual for health care professionals, 2013).
The parts of the brain that are believed to be involved in this certain disorder are the medial prefrontal cortex also known as MPFC, Amygdala, Hippocampus, and ventromedial parts of the basal ganglia. Drevets, Price, and Furey cited that “patients with mood disorders show abnormalities of morphology or morphometry in many visceromotor network structures (Drevets and Price 2005). Depending on the amount of time an individual has had the abnormalalities, they may develop aggressive moods or psychosis. The Hippocampus “is a limbic system brain structure, important in storing information in long term memory” (Stangor, 2010,. p. 73). The limbic system is also associated with a person’s emotions, which affects the mood of the person. The Amygdala, also part of the limbic system, “is responsible for regulating our perception of, and reactions to aggression and fear” (Stangor, 2010,. p. 72). Chakravarthy, Joseph, and Bapi, (2010) said that “basal ganglia (BG) are deep brain nuclei implicated in diverse and crucial functions like (1) reward-based learning, (2) exploratory behavior, (3) goal-oriented behavior,(4) motor preparation, (5) working memory, (6) timing,(7) action gating, (8) action selection, (9) fatigue, and (10)apathy” (Chakravarthy, Joseph, & Bapi, 2010).
One of the methods which have been used to study this disorder is neuroimaging. “We have developed a program of research that utilizes numerous neuroimaging modalities including positron emission tomography (PET), single photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI) to study the pathophysiology of mood disorders” (Dougherty, Deckersbach, and Ottowitz, n.d.). This is a technology that takes pictures of the brain, it helps find and diagnose many medical disorders and illnesses. Another method is genetic analysis techniques; Dr. Kiki Chang, a professor of psychiatry and behavioral sciences said “his studies promise to yield crucial information about which genes indicate risk of developing a mood disorder” (Schatzberg, n.d.). In this method, the genetic roots would be traced. “Neurotransmitters is a chemical that relays signals across the synapses between neurons” (Stangor, 2010), or in other words they are the “office boys”, running messages back and forth between the neurons. I will describe three of the neurotransmitters that are believed to function abnormally in this disorder, and how this impacts on the behavior of the individual; the first is serotonin. According to Charles Stangor, Serotonin is “involved in many functions, including mood appetite, sleep, and aggression” (Stangor, 2010., p. 67). This neurotransmitter also allows us to feel good about ourselves, helps us feel secure and safe. Furthermore, it allows us to feel happiness and increases our desire for food! If there is a decrease or increase in this neurotransmitter, it will affect the individual. Another neurotransmitter is norepinephrine; the neurotransmitter that contributes to our fight or flight response, directly increasing heart rate, triggering the release of glucose from energy stores, and increasing blood flow to skeletal muscle(Tracey, 2009). The third one is “Dopamine, a neurotransmitter effecting emotions and perceptions, is linked to psychotic symptoms such as hallucinations” (Tracey, 2009). Dopamine has many functions in the brain, including important roles in behavior and cognition, voluntary movement, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning (Tracey, 2009). These three neurotransmitters are used to keep our brains stable when either of them “mess up”, our brain and or our body will not function correctly.

References
Chakravarthy, V. V., Joseph, D., & Bapi, R. (2010). What do the basal ganglia do? A modeling perspective. Biological Cybernetics, 103(3), 237-253. doi:10.1007/s00422-010-0401-y
Dougherty, Deckersbach, & Ottowitz, (n.d.). Harvard Department of psychiatry, MGH PSYCHIATRIC NEUROIMAGING: MOOD DISORDERS SECTION. Retrieved from: http://www.hms.harvard.edu/psych/redbook/redbook-affectivedisorders-02.htm
Drevets, W., Price, J., & Furey, M. (2008). Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Structure & Function, 213(1-2), 93-118. doi:10.1007/s00429-008-0189-x
MedlinePlus Trusted health information for you (2014).,Mood disorder. Retrieved from: http://www.nlm.nih.gov/medlineplus/mooddisorders.html
Schatzberg, A., (n.d.). Pioneering Solutions for Depression and Bipolar Disorder, The Stanford Mood Disorders Center. Retrieved from: http://bipolar.stanford.edu/documents/Mood_Disorders_051513.pdf
Stangor, C. (2010) Introduction to Psychology. Irvington, NY: Flat World Knowledge, Inc.
Tracey, N., (2009). Causes of Mood Disorders – Serotonin, Dopamine, Norepinephrine. Retrieved from: http://natashatracy.com/medicationtype/antidepressants/causes-mood-disorders/

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