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Generalized Epilepsy Case Study

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Generation of very small electrical fields by synaptic currents in pyramidal neurons
Cross section of cortex: Afferents release glutamate, Open cation channels at pyramidal cell dendrites, only if thousands of neurons contribute their small voltage is the signal large enough to see at the scalp electrode forest for the trees.
Generation of large EEG signals by synchronous activity
The electric potential generated by an individual neuron is far too small to be picked up by EEG or MEG. EEG activity therefore always reflects the summation of the synchronous activity of thousands or millions of neurons that have similar spatial orientation. If the cells do not have similar spatial orientation, their ions do not line up and create waves to be detected. Pyramidal neurons of the cortex are …show more content…
Generalized seizures, as opposed to partial seizures, are a type of seizure that impairs consciousness and distorts the electrical activity of the whole or a larger portion of the brain (which can be seen, for example, on electroencephalography, EEG). Generalized epilepsy is primary because the epilepsy is the originally diagnosed condition itself, as opposed to secondary epilepsy, which occurs as a symptom of a diagnosed condition Seizure detected across entire head, begins abruptly, synchronous rhythms of about 3 Hz, ends after about 12 seconds. Causes includes Tumor, trauma, metabolic, infection, vascular disease, genetic predisposition (e.g. mutated sodium channels, altered GAGA synaptic inhibition). EEG rhythms vary with particular states of behavior. EEG grouped based on frequency range and named a Greek letter i.e beta rhythms, alpha rhythms, theta rhythms and delta rhythms. Alpha waves are Awake but non attentive large, regular. But beta waves are Awake and attentive low amplitude, fast, irregular beta

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