...DESCRIBE/DISCUSS/IDENTIFY correlations (links) between pathophysiology of the disease and its clinical manifestations. In other words, #1: how does the pathophysiology of a particular disease cause the signs and symptoms, and #2: if a patient presents the signs and symptoms of a disease, be able to use critical thinking to figure out the disease process that is most likely in that context. Objectives /outcomes for this subject: 1. the relationship between key aspects of normal genitourinary function and the pathophysiology involved in select genitourinary-related conditions, including: • female-specific disorders: endometriosis, ovarian cancer, PID, UTIs. • male-specific disorders: testicular cancer, benign prostatic hyperplasia, prostate cancer • nongender-specific problems: STIs, urologic obstructions 2. the relationship between key aspects of normal renal function and the pathophysiology involved in select renal conditions, including: • hydronephrosis. • glomerulonephritis • acute kidney injury (AKI; previously known as ARF—acute renal failure) and chronic kidney disease 3. signs and symptoms related to above pathological conditions, including significance of diagnostic test results used to evaluate and monitor renal and genitourinary function, such as: • PSA • BUN, creatinine, urinalysis, creatinine clearance 4. basic treatment modalities of the above pathologies....
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...partial fulfillment of RLE Researchers: Valdez, Shiela Mae A. Alonzo, Krizzel Marie M. Sevilla, Rica Allona N. Flores, Ma. Cristina D. Mangulabnan, Kimberly M. March 2015 I. INTRODUCTION Glomerulonephritis literally means inflammation of the glomerulus or the clusters of microscopic blood vessels in the kidney that filter wastes and fluids from the blood. It includes a number of disorders that affect the structure and function of the glomerulus without any prominent inflammation. It is therefore also referred to as glomerular disease or glomerulopathy. In glomerulonephritis, various known and unknown causes trigger immune activity against the glomeruli which damages it. It is characterized by body tissue swelling (edema), high blood pressure, decreased protein in the blood (anemia), and the presence of red blood cells (hematuria) or protein (proteinuria) in the urine. (Christian Nordqvist, Medical News Today, 2009) Collin, Rull, and Huins (2012) articulated that glomerulonephritis results from a variety of immune and inflammatory mechanisms. It is often described as primary, when it arises on its own and originated on the kidney, or secondary, when glomerular involvement is part of a systemic disease like systemic lupus erythematosus (SLE), and polyarteritis nodosa. Furthermore, glomerulonephritis can be classified as acute or chronic. In acute glomerulonephritis, the condition starts suddenly and the tissue damage progresses rapidly. With chronic glomerulonephritis...
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...therapy. In the Philippines, annually we have about 6,ooo patients started on dialysis most of which are caused by diabetis mellitus. Complications of this condition have also made this the 9th cause of death in our country. This is how important this disease entity has become over the last decade. Each of us has 2 kidneys, one on each side of our flanks. Chronic kidney disease is a permanent damage to both kidneys that persists for at least 3 months. If the kidney damage is temporary and has occurred less than 3 months, this is referred to as acute kidney or renal failure. Acuteness does not refer to the severity of the condition, but to a recent and temporary event, therefore, almost always reversible. Chronicity implies long-term event that is permanent and irreversible. This is probably why most patients fear to hear that they have kidney disease and would need dialysis. CKD has five (5) stages based on the kidney function as estimated by the glomerular filtration rate (GFR).The best overall measure of kidney function is the GFR and the preferred method for its estimation is the GFR by the Modification of Diet in Renal Disease (MDRD) calculation. In our setting, we use alternatives like the Blood Urea Nitrogen (BUN), creatinine and/or creatinine clearance. The MDRD GFR is calculated depending on the race, gender, age, height and weight of the patient and laboratory tests...
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...hospital in Miami so he could have his dialysis done and also continue to be treated for his respiratory infection.Before approaching the family, I decided to speak to the physician so I could understand this case better and try to solve the situation in the best way possible. This was the second night that this physician had been working in the emergency room, and my first time meeting her. I told the physician that the family of the patient in bed three had requested to speak to me. The physician review of the situation was as follows: The patient had been in the emergency room earlier in the week and he had been treated for an upper respiratory infection. On that first visit it was also noted that his blood urea nitrogen (BUN) and Creatinine blood levels were elevated. The patient had stated that he had missed his dialysis treatment because he had not been feeling well. On that day, the physician had discharged the patient with a prescription for antibiotic medication and discharge instructions to make sure he didn’t miss his dialysis appointment, scheduled for the following morning. On...
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...Amount of Body Fat . . . . . . . . . . . . . . 2.2.3 Predicting Detection Period . . . . . . . . . . 2.3 Positive (defined) . . . . . . . . . . . . . . . . . . . . 2.3.1 Passive smoke and positives . . . . . . . . . . 2.4 Decreasing detection times . . . . . . . . . . . . . . . 2.4.1 Physical Activity . . . . . . . . . . . . . . . . 2.4.2 Diet . . . . . . . . . . . . . . . . . . . . . . . 2.4.3 Using Drugs to Reduce Detection Times . . . 3 Test Methods 3.1 Substances that are Detectable . . . . . . . . . . . 3.2 DrugAlert . . . . . . . . . . . . . . . . . . . . . . . 3.3 Gas Chromatography . . . . . . . . . . . . . . . . . 3.4 Gas Chromatography / Mass Spectrometry . . . . . 3.5 Hair testing . . . . . . . . . . . . . . . . . . . . . . 3.6 High Performance Liquid Chromatography . . . . . 3.7 ImmunoAssay . . . . . . . . . . . . . . . . . . . . . 3.7.1 Radio ImmunoAssay (aka AbuScreen) . . . 3.7.2 Enzyme Multiplied Immunoassay Technique 3.7.3 Fluorescence Polarization ImmunoAssay . . 3.8 PharmChek . . . . . . . . . . . . . . . . . . . . . . 3.9 TestCup . . . . . . . . . . . . . . . . . . . . . . . . 3 11 13 13 13 15 16 16 16 17 17 18 18 18 19 19 21 21 21 22 24 24 25 25 25 26 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 CONTENTS 3.10...
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...Rationale: Small bowel obstruction and resection benefit TPN over tube feedings is that all the nutrition is delivered at a cellular level making it immediately available for the body to utilize rather than making the body breakdown and absorb nutrients in the GI tract. It makes it easier on the digestive tract by giving the GI a chance to rest and heal without causing more harm. The patient also has to expend energy to breakdown foods/nutrition through the GI tract. Getting it TPN conserves the much needed energy the patient needs to heal their tissues and gain strength. | Activity: bedridden w/slight mobility with a walker | Rationale: Post surgical abdominal surgery, pt age, weakness, and recent foot surgery limiting her mobility. | Behavior/Affect: My pt was anxious when I first arrived due to her elevated B/P, N&V, and pain intolerance. By the end of shift my patient was very calm and communicative. | Isolation: | Yes | No | Culture: ⦵ | Source: ⦵ | Type of Isolation: ⦰ ⦵ | Height: 5’ 7.5” | Weight: 133 | BMI: 20.5 (BSA 1.71) | General Survey | Age: 85 | Sex: F | Ethnicity: Caucasion | # of days since admission: 7d | Allergies: Latex PCN | Code Status: FULL CODE | Diet: TPN | Rationale: Small bowel obstruction and resection benefit TPN over tube feedings is that all the nutrition is delivered at a cellular level making it immediately available for the body to utilize rather than making the body breakdown and absorb nutrients in the GI...
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...and hypotension. C.W. underwent surgery for his gastrointestinal bleed and then was admitted to the hospital for having a fluid volume deficit, due to his diarrhea and bleed. C.W. being volume deficit made his fluid, electrolyte and blood levels become very abnormal. His medication that he was on for prior health history was causing some of his levels to rise and drop. He has a past medical history of cardiovascular problems, which were described and attributed to his current admitting problems. While at the hospital he went into sinus tachycardia and was placed on a Swan-Ganz catheter. One of the main goals for treating C.W. is to control his tachycardia and control his levels. He has some serious cardiovascular conditions that can not be healed but medical professionals, using education and medication , can better his quality of the life he has left. Patient C.W., a 70-year-old male, was admitted to the hospital at 0430 with a 25-X15-mm duodenal ulcer causing a gastrointestinal bleed, which was presented by “ dark red “ bloody diarrhea. His wife states that he has had diarrhea for 3 days with “dark red” stool starting the night before. She states that when he became “very dizzy, disoriented and weak” in the morning she decided to bring him to the hospital. He went through surgery, which was successful, but then was admitted to the medical intensive care unit for his volume deficit. C.W. has a history of having an idiopathic dilated cardiomyopathy, which has now become a...
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...particularly diligent in their drug testing efforts. If your prospective employer has around 100 employees or has government or private financial backing, you can bet your bottom dollar that you will be tested; if not for pre-employment, then at some point during your tenure with that company. To simplify things, your prospective employer is only testing for illegal drugs during a drug screening. They cannot, by law, test for pregnancy or medical conditions during a drug test. Thankfully, prospective employers cannot run your urine, hair, saliva or blood and see what substances or activities in which you have engaged over the last ten years. Such actions are not only illegal – they are currently impossible. In this Guide, you will learn how long the chemical traces, or metabolites, stay in your system (for example, marijuana can stay in your blood stream for as long as two months!). The Department of Defense requires frequent, observed tests of its military personnel, as do parole/probation officers. Employment tests, however, are rarely observed, provided your first test proceeds without complications. If you have even the slightest concern of being caught with a positive result on your impending drug test, this Guide will help you. Practically speaking, the information contained herein could very well...
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...ACUTE GLOMERULONEPHRITIS DISCLOSED _________________________ A Case Study Presented to The Clinical Instructors AUP College of Nursing Adventist University of the Philippines __________________________ In Partial Fulfillment of the Requirements for the Course NMCN 244, Care of Mother, Child, Family and Population at Risk ___________________________ TABLE OF CONTENTS I. Introduction Significance of the Study II. Patient DataBase A. Demographic Data B. Nursing History 1. Developmental Tasks 2. Health History 3. Medical Diagnosis & Chief Complaints III. The Disease Entity A. Review of Normal Physiology B. Theoretical Background C. Statistical Report D. Risk/Aggravating Factors E. Pathophysiology Narrative w/ Documentation F. Pathophysiology Diagram G. Prognosis of Disease IV. Assessment A. Gordon’s or Head to Toe Assessment B. Book Picture vs Patient’s Manifestations V. The Management A. Diagnostic Test Result and Significant B. Therapeutic/Medical Interventions 1. Surgeries/Treatment 2. Drugs C. Nursing Initiated Interventions 1. Nursing Care Plan 2. Discharge Plan VI. General Evaluation of the Study A. Summary B. Recommendation VII. Bibliography I. Introduction Acute glomerulonephritis is a disease that affects glomerular capillaries. Etiologic factors are many and varied; they include immunologic reactions, vascular injury, metabolic...
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...Final Exam Study Guide Important to Know the function of anterior and posterior pituitary gland. Anterior Pituitary Gland: (Adenohypophysis) The anterior pituitary gland regulates several physiological processes including stress, growth, reproduction and lactation (Adrenal, liver, bone, thryroid and gonads). -It is regulated by negative feedback and the hypothalamus. Major hormones: ACTH: Stimulates the adrenal cortex. TSH: Thyroid stimulating hormone, promotes secretion of thyroid hormone. FSH: Follicle-stimulating hormone, promotes growth of reproductive system. LH: Luteinizing hormone. Promotes sex hormone production GH: Growth hormone, promotes growth, lipid and carbohydrate metabolism. PRL: Prolactin, Milk production and progesterone/estrogen. -Hormones are secreted from the hypothalamus to the A. Pituitary so these hormones can be released. Posterior Pituitary Gland: Mainly axons extended from the hypothalamus. These axons contain and release neurohypophysial hormones oxytocin and vasopressin. Oxytocin: Targets the uterus, and mammary glands causing contractions and lactation. Vasopressin (ADH): Antidiuretic hormone, arginine vasopressin, argipressin. Stimulates water retention absorbs it back into blood causing raises blood pressure by contracting arterioles, and inducing male aggression. Very Important to know and understand Diabetic Ketoacidosis Pathophysiology: -In DKA, the lack of insulin prevents glucose from being utilized by the tissues...
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...Makati Medical Center - College of Nursing SY 2011 – 2012 A Case Study Presentation on the Care of a Mother with Preeclampsia Superimposed on Chronic Hypertension In Partial Fulfillment of the Course Requirement of NCM102 – Related Learning Experience Submitted To: Submitted By: Leader: Knight, Catherine P. Members: Iglesias, Pauleen Itliong, Juliane B. Javier, Reniccia Janel Joaquin, Gian Denise M. Kwek, Michael Angelo L. La Sangre, Anne Gabrielle B. Lacerna, Iruel Victor III Leynes, Sofia Antonniette M. Lindawan, Ma. Kristine S. BSN II – B Group 2 December 17, 2011 Table of Contents Chapter I - Introduction A. Description of the Case………................................................................. 4 B. Purpose and Objectives........................................................................... 5 C. Significance and Justification....................
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...branch office in Chennai on 15th November 2002, disrupting the Annual General Meetings (AGMs) of HLL held on 13th June 2003 and 29th June 2004, shouting slogans and brandishing placards and enlisting sympathy from ex-workers and the general public. Greenspace also maintained the pressure on HLL through its website, photoalbums, posters, persistent media briefing and seminars. The NGOs had most recently attacked HLL in April 2004 in a seminar in Chennai. Even as they waited anxiously for the regulator, Tamil Nadu Pollution Control Board’s (TNPCB) nod to start decontamination of equipment and remediation of soil, HLL’s senior managers believed they had discharged their duties conscientiously. They wondered what more was needed to be done to bring the whole episode to an amicable closure. Why had the events turned out to be far more complicated than anticipated? Background Note HLL, a 51% subsidiary of the Anglo-Dutch Conglomerate, had acquired a tremendous reputation as one of India’s best-managed companies. Despite being the subsidiary of a Multinational Corporation (MNC), HLL was perceived to be more Indian than foreign,...
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...office in Chennai on 15th November 2002, disrupting the Annual General Meetings (AGMs) of HLL held on 13th June 2003 and 29th June 2004, shouting slogans and brandishing placards and enlisting sympathy from ex-workers and the general public. Greenpeace also maintained the pressure on HLL through its website, photoalbums, posters, persistent media briefing and seminars. The NGOs had most recently attacked HLL in April 2004 in a seminar in Chennai. Even as they waited anxiously for the regulator, Tamil Nadu Pollution Control Board’s (TNPCB) nod to start decontamination of equipment and remediation of soil, HLL’s senior managers believed they had discharged their duties conscientiously. They wondered what more was needed to be done to bring the whole episode to an amicable closure. Why had the events turned out to be far more complicated than anticipated? Background Note HLL, a 51% subsidiary of the Anglo-Dutch Conglomerate, had acquired a tremendous reputation as one of India’s best-managed companies. Despite being the subsidiary of a Multinational Corporation (MNC), HLL was perceived to be more Indian than...
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...Chapter 1 Introduction to Pathophysiology Lee-Ellen C. Copstead Key Questions • What is pathophysiology? • How are etiology and pathogenesis used to predict clinical manifestations and response to therapy? • How are normal and abnormal physiologic parameters defined? • What general factors affect the expression of disease in a particular person? • What kinds of information about disease can be gained through understanding concepts of epidemiology? http://evolve.elsevier.com/Copstead/ • Review Questions and Answers • Glossary (with audio pronunciations for selected terms) • Animations • Case Studies • Key Points Review Pathophysiology derives from the intersection of two older, related disciplines: pathology (from pathos, suffering) and physiology (from physis, nature). Pathology is the study and diagnosis of disease through examination of organs, tissues, cells, and bodily fluids. Physiology is the study of the mechanical, physical, and biochemical functions of living organisms. Together, as pathophysiology, the term refers to the study of abnormalities in physiologic functioning of living beings. Pathophysiology seeks to reveal physiologic responses of an organism to disruptions in its internal or external environment. Because humans exhibit considerable diversity, healthy structure and function are not precisely the same in any two individuals. However, discovering the common and expected responses to abnormalities in physiologic functioning is useful, and it...
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...Applied Statistical Methods Larry Winner Department of Statistics University of Florida February 23, 2009 2 Contents 1 Introduction 1.1 Populations and Samples . . . . . . . . . . . 1.2 Types of Variables . . . . . . . . . . . . . . . 1.2.1 Quantitative vs Qualitative Variables 1.2.2 Dependent vs Independent Variables . 1.3 Parameters and Statistics . . . . . . . . . . . 1.4 Graphical Techniques . . . . . . . . . . . . . 1.5 Basic Probability . . . . . . . . . . . . . . . . 1.5.1 Diagnostic Tests . . . . . . . . . . . . 1.6 Exercises . . . . . . . . . . . . . . . . . . . . 7 7 8 8 9 10 12 16 20 21 25 25 29 29 29 32 32 32 32 32 35 35 37 38 38 39 40 42 42 44 48 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Random Variables and Probability Distributions 2.1 The Normal Distribution . . . . . . . . . . . . . . . . . . 2.1.1 Statistical Models . . . . . . . . . . . . . . . . . 2.2 Sampling Distributions and the Central Limit Theorem 2.2.1 Distribution of Y . . . . . . . . . . . . . . . . . . 2.3 Other Commonly Used Sampling Distributions . . . . . 2.3.1 Student’s...
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