According to UN estimation, one third of the world’s population lives in water shortages areas. Even today, about 1.1 billion people are living without access to safe drinking water (Shaw and Thaitakoo, 2010). In reality, some of the countries in the world have severe water scarcity; especially in African countries. This worst scenario is also knocking at the door of Bangladesh. Particularly, Southwestern region of Bangladesh faces safe drinking water supply due to natural contamination of arsenic in the groundwater, salinity intrusion and drought as well. At present, different governmental officials, international, national and local NGOs, private sectors and community people are trying to overcome the crisis of drinking water individually and/or combined in different ways. But they are focusing a single issue rather than keeping all issues in an integrated way. However, the problem of safe drinking water availability caused by the combined effect of salinity, arsenic, and drought which are intimately inter-linked with each other. Therefore, it is imperative to include all the issues by developing an integrated approach, which will help to find a successful solution for better access of safe drinking water in the affected area.

In view of the above mentioned issues, this study developed a holistic approach named “SIPE” that helps to find out/determine safe water adaptability index considering socio-economical, institutional, physicochemical and environmental aspect of the study area. Finally the outcomes from the analysis help to enhance formulating safe water adaptability action plan that will be practiced through national level to local level to get safe drinking water.