In the article clinical epidemipology of Alzheimer’s disease the author is trying to assess the sex and gender differences observed in the incidence and prevalence of Alzheimer disease and Mild Cognitive Impairment. The author is also trying to research on the protective factors and gender-specific risk of Alzheimer disease. Both sex and gender play crucial roles in the development and progression of the Alzheimer disease. Researchers have a required to understand both sex and gender precise risk and Alzheimer protective factors in order for them to develop ways of the disease prevention and cure. The other uses the findings of David Barlow where he states that Alzheimer disease is the most prevalent type of dementia. Serge Gauthier previously found out that Alxheimer’s disease is characterized by loss of memory. This is a characteristic that distinguishes the disease from other cortical degenerative diseases. The author supports Hebert and Scherr findings that fourteen to sixteen million Americans will be diagnosed with the illness by 2050 unless research comes up with new treatment of the disease. The author supports a finding by Petersen RC that says the men have a higher threat of developing mild cognitive impairment. Knopman DC also supports that men have higher chances of being diagnosed with mild cognitive impairment. These previous findings show that Alzheimer’s disease have incidence and prevalence differences between men and women. The author of the article main purpose of investigating the topic was to discuss the previous research by other authors. The methods the author uses are very similar to the previous findings he had quoted in the article. The author’s findings are supported by previous author’s findings like Knopman and Petersen who have stated that men have higher prevalence’s of the mild cognitive impairment. The article is entirely a replication from other previous findings. The previous studies failed to estimate the future disease diagnosis between men and women. The author adds that Alzheimer disease has a present record of 5 million people affected in the United States of America alone. The author adds that in 2050 the number may triple if quality treatment is not discovered. The author used survey type of design method to study the population. The author surveyed a population that consisted people of different ages and gender. This wide range of the population assisted the author to have a wide range of results and statistics in which he could analyze and come up with correct results. The author of the article was investigating whether the Alzheimer’s disease and Mind Cognitive Impairment had prevalence differences across the two sexes and gender types. The author was also investigating the American diagnosed population with the Alzheimer’s disease. He also investigated on the prevalence of MCI depending with the individual’s age. The factors of investigation have been measured by the author. The author uses a population that consists of people of different ages and genders. The author measures the compares the results with previous studies and findings on the same topic. This guides the author on making conclusions about the factors being investigated. The author uses a wide range of age distribution to investigate the factors. The author has used a large population so that he can get wide statistics result that will guide him in making a conclusion of the factors being investigated. It was important for the author to use both men and women as a population for the study. The study also did an autopsy study that assisted the author that to develop a hypothesis that states that women had meaningfully higher chances of a clinical diagnosis of Alheizmer’s disease at the equal of pathology. The study was done in American, Europe and Asia. The author states that thirteen studies done in Europe, U nited States and Asia showed that women were at a greater risk of developing Alheizmer’s disease but not the other dementias. The study was also done in different cultural ethnicities because the author of the article states that some differences of results observed in Asia, Europe and North America were as a result of the cultural, historical and social events present in those areas. During the study the population was not informed the main goal of the survey. There was some kind of deception during the collection of the statistics from the population sample. The main message of the article is to show the differences that were observed in men and women in the Alheizmer’s disease and Mild Cognitive Impairment prevalence and occurrence. The article goes further to explain these differences by showing the different arrangement and functions of the brain, hormonial differences and gonadal differences between men and women. The author says that the research shows how the prevalence of Alheizmer’s diseases varies across gender due to the difference brain formation and structure. The previous studies had not researched deeper to show why the prevalence of the disease differs between men and women. The author says that the results of the article will help research to discover new treatment and preventive measures by the first understanding the difference of men and women structures and characteristics. These results will assist in discovering a cure of the disease which has not yet been discovered. The study states that the current permitted medications do not adjust to the fundamental disease pathology. This means that with the help of the study will assist researchers to stratify their research based on sex and take sample tests on women and men separately. This study rounds up the information by stating that the results will help the society by the knowledge that a drug can have an effect on one sex and lack effect on the other. The results will help the society to predict the future Alheizmer’s diseases burden. The paper has come up with a new discovery of the differences between men and women in certain diseases. I totally agree with the author’s research that researchers should carry out research on diseases with the knowledge in mind that men and women are different in terms of body compositions. A future study can be done to research how different individual age affects the prevalence and treatment of a disease. It is important for researchers to understand that social, historical and cultural trends have an impact on future prevalence and occurrence of Alheizmer’s diseases. Such research assists future discovery of treatment and medication of diseases such as Alheizmer. Thus the international health research unit should embrace the findings of this article and also put them into practice.