...coordination complexes. In this experiment, the metal use is copper (II) ion which is crystal blue in colour when it is copper(II)nitrate. All metal ions in solution can react well with water. The water molecules can also be weakly bonded or more strongly as a ligand to form a complex ion, and these can also present in solid ‘hydrated’ salts of crystallization. For example, copper (II) nitrate (Cu(NO3)2∙3H2O) A complex ion has a metal ion at its center with a number of other molecules or ions surrounding it. These can be considered to be attached to the central ion by co-ordinate (dative covalent) bonds. The molecules or ions surrounding the central metal ion are called ligands. Simple ligands include water, ammonia and chloride ions. All ligands are lone pair donors. In other words, all ligands function as Lewis Bases. A base is an electron pair donor and an acid is an electron pair acceptor. Ligands like water, can donate a pair of non-bonding electrons(lone pair) intro a vacant orbital of a central metal ion and so dative covalent(co-ordinate) bonds hold a complex together. The central metal ion with vacant bonding orbitals can act as a Lewis acid. Ligands act as Lewis bases by electron pair donation to form the metal-ligand bond. Apparatus : filter paper , Buchner funnel, adapter, suction filtration flask, spatula, graduated cylinder, watch glass, glass rod, pipette Chemicals : water, copper (II) nitrate (Cu(NO3)2∙3H2O), 1:1ammonia solution, acetyl acetone Procedure :...
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...Hardness Determination for Water Samples* Purpose To introduce the concept of complex formation and stability and to illustrate the analytical application of this concept to the measurement of hardness in water. To determine the total hardness for water and test for Ca and Mg solutions and unknown samples. Introduction Hardness of water is a property caused by the presence of polyvalent metal cations, primarily Ca2+ and Mg2+ in natural waters. Hardness is undesirable in a water supply because it results in scale formation and in soap wastage (Sample Lab, Fiu). If one ever has gone to a place where ground water is abundant and is used for drinking and cooking, one can see that the pots have a white mark done to the long exposure to the metals that these water contains, or the shampoo doesn’t produce bubbles. Chelation process is usually the one used most frequently to measure water hardness. The metal ions in this water may have electrons that can be shared in pairs with a donor to form a coordination bond. If a molecule or ion has more than one "free" electron pair which can be shared with a metal ion or similar species, it is called a chelating agent. The complex is termed a chelate. The chelating reagent that we will be using in this lab is EDTA (ethylene-diamine-tetra-acetic acid ). This reagent is the most commonly used for this purpose. As the name inplies, EDTA is a an acid, a tetraprotic one. In the completely deprotonated form, EDTA can form coordination...
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...shift of HINT1 if the ligands interact with the protein. HINT1 gene is associated with schizophrenia and bipolar disorders, and therefore the binding ligand might be a potential drug target for mental disorders. Through the understanding of interaction increases the identification for drug design. Two ligands, GMP and 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) are used in the practical. GMP is a well-known binding ligand to HINT1, and it will be a validation for determination of AICAR phosphate and AICAR. AICAR is known as a nucleoside mimetic and a potential candidate. The NMR samples for ligand titration contain 0.2 mM 15N labelled, HINT1, 50 mM sodium phosphate, 50 mM NaCl, pH 7.3, in 90% H2O and 10% D2O. The HINT1-ligand reaction occurs by titrating 50 mMsolution for GMP or 20 mMfor AICAR to a 0.2 mM HINT1, respectively. 1H–15N two dimensional (2D) heteronuclear single quantum coherence (HSQC) spectra can be obtained to assess the structural change of HINT1. NMR spectra were recorded at 25℃, and 1H–15N HSQC spectra were recorded on a Bruker 600 using 1024 points and 128 increments. The software programmes named NMRPipe and NMRDraw are responsible for analysis. The results of saturation-transfer difference (STD) NMR are shown in figure 1. Section A represents the STD data for GMP as well as two other ligands AICAR phosphate (B) and AICAR (C). The presence of the residual NMR signal is observed in the STD experiment, namely the ligands might interact with HINT1...
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...bis(acetyacetonato) copper(II) complexTheory/Background:All metal ions in solution are 'associated' with water. The water molecules can also beweakly bonded or more strongly as a ligand to form a complex ion, and these can also present in solid 'hydrated' salts of crystallization. E.g Copper(II) nitrate (Cu(NO 3 ) 2 .3H 2 O).A complex ion has a metal ion at its centre with a number of other molecules or ionssurrounding it. These can be considered to be attached to the central ion by co-ordinate(dative covalent) bonds. The molecules or ions surrounding the central metal ion arecalled ligands. Simple ligands include water, ammonia, acetyl acetone and chloride ions.Ligand has active lone pairs of electrons in the outer energy level. These are used to formco-ordinate bonds with the metal ion. All ligands are lone pair donors. In other words, allligands function as Lewis bases.Lewis acid-base theory reminders:A base is an electron pair donor and an acid is an electron pair acceptor.Ligands like water, can donate a pair of non-bonding electrons (lone pair) into a vacantorbital of a central metal ion and so dative covalent (co-ordinate) bonds hold a complextogether.The central metal ion with vacant bonding orbitals can act as a Lewis acid.Ligands act as Lewis bases by electron pair donation to form the metal-ligand bond.Bronsted-Lowry acid-base theory reminders (essentially a sub-set of Lewis Theory)A base is a proton acceptor.This is via an electron lone pair on the base (a Lewis base...
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...outer-sphere processes. Electron transfer reactions play an essential role in many physical, chemical and biological processes. The investigation of the mechanisms of these reactions rests essentially on the systematic investigation of structure-reactivity relationships that results from the geometric rearrangements which accompany the change in oxidation states of the coordination compounds. Although many theories have been proposed, it is no surprise that the more simpler ones such as Marcus theory are the most popular.1 In spite of the great success of the theory of Marcus in interpreting several of these structure-reactivity relations namely in terms of the reaction energy (AG), changes in equilibrium bond lengths (lred-lox) and metal-ligand force constants (fox and fred), several problems remain. ANOMALOUS FEATURES OF ELECTRON TRANSFERS Marcus theory and related approaches emphasize the importance of the reaction energy barrier of the solvent...
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...Initially, Dylan was treated with EDTA and then DMSA. 1. What are EDTA and DMSA and how might they reduce the high levels of lead in Dylan’s tissues? EDTA ~ Ethylenediaminetetraacetic acid, EDTA is an aminopolycarboxylic acid; a colourless, water-soluble solid, its usefulness comes from its ability to sequester metal ions and act a chelating agent, a hexadenate ligand. Once metal ions are surrounded to the EDTA (1), they remain in solution but become less reactive, “chelation therapy” EDTA was first approved for use in 1953 by the U.S ~ FDA. DMSA ~ Dimercaptosuccinic acid, An organosulphur compound, a meso isomer also used as a chelating agent, its primary use is for the treatment of lead poisoning, again a colourless solid containing two carboxylic acid and two thiol groups, which give a distinct foul odour (5). Established by Chinese scientists in 1957 to be effective in...
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...some extent rinse water contain silver thiosulfate complex ions. They are far less toxic than free silver ion, and they become silver sulfide sludge in the sewer pipes or treatment plant. However, the maximum silver concentration in discharge is very often tightly regulated. Silver is also a somewhat precious resource. Therefore, in most large scale processing establishments, exhausted fixer is collected for silver recovery and disposal. Many photographic chemicals use non-biodegradable compounds, such as EDTA, DTPA, NTA and borate. EDTA, DTPA, and NTA are very often used as chelating agents in all processing solutions, particularly in developers and washing aid solutions. EDTA and other polyamine polycarboxylic acids are used as iron ligands in colour bleach solutions. These are relatively nontoxic, and in particular EDTA is approved as a food additive. However, due to poor biodegradability, these chelating agents are found in alarmingly high concentrations in some water sources from which municipal tap water is taken.[7][8] Water containing these chelating agents can leach metal from water treatment equipment as well as pipes. This is becoming an issue in Europe and some parts of the world.[citation needed] Another non-biodegradable compound in common use is surfactant. A common wetting agent for even drying of processed film uses Union Carbide/Dow Triton X-100 or octylphenol ethoxylate. This surfactant is also found to have estrogenic effect and possibly other harms to...
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...excellent two electron donor ligands towards almost any element in the periodic table. They coordinate strongly to late transition metals and heavy main group elements, but are also known to bind to early transition metals and the lanthanoids. However, there are alternative methods to prepare air- and moisture-stable species that can be used to transfer carbenes to other metals. In particular this involves the preparation of imidazolium salts and reacting it with Ag2O to form robust silver complexes.(1) Discussion: (1) Formation of imidazolinium chlorides from corresponding aniline C2H4Cl2 (l)+ 2C6H7N (l) + C7H16O3 (l) 2C21H25ClN2 Synthesis of (SIPr)AgCl 2SIPr.HCl (l)+ AgO(s) → 2 (SIPr)AgCl(l) + H2O(l) (2) The NHC ligand is significantly more tightly bonded than the phosphine ligand as a consequence of the larger energetic contributions of the σ-donation, π-back-donation. Back-bonding in carbonyl and phosphine metal complexes influence the bond strength. Donation of electrons from the filled π-orbital or lone electron pair orbital of the ligand into an empty orbital of the metal (donor–acceptor bond), together with release (back donation) of electrons from an nd orbital of the metal (which is of π-symmetry with respect to the metal–ligand axis) into the empty π*-antibonding orbital of the ligand. (2) Singlet carbenes are also highly basic and are powerful electron donors. These properties make carbenes exceptionally good ligands for a wide variety of metals...
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...Trade name: Jadenu Generic name: Deferasirox Application number (NDA): 206910 Approval date: March 30, 2015 Jadenu is a new drug which is approved as an iron chelator and used for the treatment of chronic iron overload due to the transfusion of blood. This drug is approved for reducing the iron concentration in liver and serum ferritin levels. It is used for chronic excessive iron in liver in the patients who are 10 years and older and suffering from Non Transfusion Dependent Thalassemia syndrome in which iron and serum ferritin gets overloaded in the liver and can cause toxicity. It is also used in patient suffering from sickle cell diseases. Approval Details: This drug is manufactured by Novartis Pharmaceutical Cooperation (Oncology Department). The New Drug Application was submitted under section 505b of Federal Food, Drug and Cosmetic Act on May 30th, 2014. FDA approved the product under accelerated approval regulations 21 CFR314.510 and requested further clinical trials and well controlled studies to explain the clinical benefit of this drug. FDA also requested to submit the post marketing requirements under section 505 (o) and the promotional material. Dosage and Administration: Initial dose is 14 mg/kg for transfusion iron overdose and...
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...COUNTRY ANALYSIS REPORT: MEXICO VS U.S.A HEALTHCARE MERCK - DIABETES Group 14 – Campus Santa Fe: Angelica Hidalgo 1461526 Alejandro Meza 1464801 Cinthia Merlos 1462113 Juan José Ibarra 1465263 April 10th, 2012 INDEX 1. INTRODUCTION 2. ECONOMIC VARIABLES 3. POLITICAL VARIABLES 4. SOCIO –CULTURAL AND DEMOGRAPHIC VARIABLES 5. COUNTRY ATTRACTIVENESS SCORE 6. THE DECISION 7. EXHIBITS 8. BIBLIOGRAPHY 1. INTRODUCTION 2. ECONOMIC VARIABLES The total economic impact of diabetes worldwide In the world the economic impact about the diabetes was 376 billion dollar in 2010, this is the 11.6% of the total healthcare budget in the world. This facts give us an idea about how is important to analyze the impact in economies of this disease and we are going to go deeper for the analysis of Mexico and United States of America. MEXICO In Mexico the economic impact due to diabetes cost more than 7 billion dollars in 2011 according to the Instituto Nacional de Salud Publica. And is expected an increase of 15% this year of 2012 this impact is really huge because 50% of this expense was made by families and the other 50% was made by government in Latin America Mexico is the country...
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...coupled receptors (GPCRs), whereas 5-HT3 is uniquely ionotropic, (Engleman et al., 2008) (see Fig. 1.) Walstab, J., Rappold, G. and Niesler, B. (2010). 5-HT3 receptors: Role in disease and target of drugs. Pharmacology & Therapeutics, 128(1), pp.146-169. Fig. 1. Schematic of a typical 5-HT3 receptor, showing the cation lumen after the removal of a subunit. Arrows point to reveal the agonistic, competitive, non-competitive antagonists and positive modulators. The orthosteric ligand binding site is magnified to show the binding loops of neighbouring subunits. An arrow also shows the transmembrane (TM) domains of an individual subunit, with TM2 lining the channel pore. A pentemeric receptor consisting of four TM segments to form an intrinsic cation selective, water-filled channel (Barnes et al., 2009). A typical subunit exhibits a large extracellular N-terminus (Iversen, 2009) and a short extracellular C-terminus (Mukerji, Haghighi and Séguéla, 1996). As a member of the cys-loop family of ligand-gated ion channel receptors, 5-HT3 channel opening is a result of the extracellular connection of an agonist to a distinctive binding site on the channel protein. A conformational change occurs resulting in the opening of the central ion pore, where ion...
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...Salix has been a successful pharmaceutical company for 15 years. They have used the “search and develop strategy” in the US GI market for continued growth. The question remains can they continue to be successful with this narrow strategy or do they need to alter their mission? Do they need to revamp their “search and develop” strategy? Key issues Salix encounters are increased use of generics, limited scope of disease treatment, and dependency upon other research companies to initially start and develop chemicals. If Salix wants to expand their strategy scope, they could focus on medications in other areas of the body, they could expand outside of the US market, they could further develop their international partner network, or they could focus on their own research instead acquiring licenses and rights to other chemicals. Introduction Salix is a small pharmaceuticals company started in 1989. Since this time, Salix has acquired the rights to develop and market four major prescription compounds. They have become a successful player in the US gastrointestinal market, while profiting from licensing their products in other countries. Although Salix has been successful, the co owners must make a decision on whether or not their current strategy is sustainable. Can they still “search and develop” acquired compounds and stay successful? Salix needs to determine if their existing prescription drugs’ profitability can last while they find another research companies drugs...
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...Asst Manager Maintenance Asst Manager Quality Control Jr. Manger (Q.A)- A 4 3 1 4 1 5 1 Supervision of Production Activities 14500 do 14500 do 14500 do 10840 6 Jr. Manger (Q.A)- B 1 MSc (Pharmaceutical 1640-60-2600In charge of Quality Chemistry)/ MSc (Micro Biology) with 2 years 75-2900 Assurance experience in the relevant field. do 10840 7 Jr. Manger (Q.C) 2 B.Pharm with 2 years experience OR Msc. In charge of Quality (Chemistry)with 2 years 1640-60-2600Control 75-2900 experience/ BSc (Chemistry) with 5 to 7 years experience in relevent Field do 10840 STAFF/WORKERS:TECHNICAL 750-40-950-50B.Sc. (Chemistry) with D.Pharm 1200-60-1500Industrial DA Production of Drug and minimum 3 years 70-1990-80based on cost experience in Pharmaceutical Formulations 2390-95-2865- of living Index production 110-3415 630-25-755-30Minimum 10th Standard + ITI in 905-35-1080Production of Drug Fitter/ Machinist Trade with 2 40-1360-45years experience in a Formulations 1585-55-1860Pharmaceutical Company 65-2185 Minimum 10th Standard + ITI in 605-20-705-25Production of Drug Fitter/ Machinist Trade with 1 830-30-950-35Formulations year experience in a 1230-40-1430 Pharmaceutical Company 630-25-755-30Minimum 10th Standard + ITI in 905-35-1080Maintenance of Plant &Mechanical Fitter Trade with 2-5 years 40-1360-45experience in the relevant field 1585-55-1860Equipements 65-2185 1 Supervisor (Foreman grade) 2 9126 ...
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...Research Paper AstraZeneca Pharmaceuticals, (AZN) is one of the world's leading pharmaceutical companies with 57,000 employees worldwide in over 100 countries. Its corporate headquarters are in London, research and development headquarters are in Södertälje, Sweden, and its manufacturing facilities employ 9,600 people in 16 different countries. The company operates fourteen research and development sites in eight countries and has sales in over 100 countries around the world. AstraZeneca focuses its pharmaceutical business on seven key therapeutic areas: anesthesia and pain control, cardiovascular, central nervous system, gastrointestinal (it is a world leader in this therapeutic area), infection, oncology, and respiratory. Its product range includes such blockbusters as Nexium, Crestor, Seroquel, and Symbicort. AstraZeneca was formed as the result of the 1999 merger of two European pharmaceuticals companies: Astra AB of Sweden, a maker of pharmaceutical products and medical devices, and Zeneca PLC of the United Kingdom, a bioscience company focusing on pharmaceuticals, agricultural and specialty chemicals, and disease-specific healthcare services. One year after its merger, the company achieved sales of US$15.8 billion, with an operating profit of US$4 billion. In 2011, company sales and operating profit were $33.6 billion and $13.2 billion respectively. AstraZeneca is one of the world's largest pharmaceutical companies, with FY2011 sales of $33.27 billion and $10...
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...competitive in the today’s economy characterized by the globalization. By the way, Lot of changes has taken place in the health care industry. And the most significant change involves the growth of managed care in the health care industry. Managed care plans typically provide members with medical insurance and basic health care services, using volume and long-term contracts to negotiate discounts from health care providers. In addition, managed care programs provide full coverage for prescription drugs more frequently than do traditional medical insurance plans. Industry expert’s estimate that by the turn of the century, 90% of Americans will have drug costs included in some kind of managed health care plan, and 60% of all outpatient pharmaceuticals will be purchased by managed care programs. Knowing that the responsibility for managing the provision of prescription drugs is often contracted out by the managed care organizations to PBMs. As the key aspect of the shift to managed care is that the responsibility for payment is...
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