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Multiple Sclerosis Synthesis

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Multiple Sclerosis is an autoimmune disease as a response to the attack of the T-cells from the bloodstream on the central nervous system causing damage to the myelin sheaths of the CNS nerves leading to the formation of scar tissue known as sclerosis that prevents nerve impulses from traveling to and from the brain and spinal cord. MS is a result of the interactions between the mutated gene DDX39B and the gene IL7R. The DDX39B gene regulates the protein expression by splicing the IL7R exon 6; however, when the gene is mutated, the variant C allele enhances alternative splicing of IL7R exon 6, leading to the production of soluble sIL7R or the mutated form of IL7R. To determine the effects of the DDX39B gene, the DDX39B expression was suppressed

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