(2 points) Briefly describe how WSI technology works.
Whole Slide Imaging (WSI) is creating a digital image from an entire microscope slide. An automated microscope (slide scanner) scans an entire slide and stores a digital image. Then the digital image can be viewed, managed, and analyzed using a computer. There are computer algorithms that can numerically analyze the stored digital images and produce cheaper and faster results compared to manual slide analyses.
b) (2 points) Discuss one advantage of WSI technology.
WSI technology has reduced turn-around time. Diagnosis and numerical analyses like counting can be done automatically and faster using computer algorithms.
c) (2 points) Discuss one disadvantage of WSI technology.
It is a new technology. It …show more content…
Please include the citation for the study you selected.
Study title:
Validation of Whole Slide Imaging for Primary Diagnosis in Surgical Pathology [2]
Objective:
To compare WSI versus microscope slide diagnoses of previously interpreted cases after a 1-year delayed re-review (‘‘wash-out’’) period.
Design:
A priori power study estimated that 450 cases might be needed to demonstrate noninferiority, based on a null hypothesis: ‘‘The true difference in major discrepancies between WSI and microscope slide review is greater than 4%.’’ Slides of consecutive cases interpreted by 2 pathologists 1 year prior were retrieved from files, and alternate cases were scanned at original magnification of X20. Each pathologist reviewed his or her cases using either a microscope or imaging application. Independent pathologists identified and classified discrepancies; an independent statistician calculated major and minor discrepancy rates for both WSI and microscope slide review of the previously interpreted cases.
Results:

The 607 cases reviewed reflected the subspecialty interests of the 2 pathologists. Study limitations include the lack of cytopathology, hematopathology, or lymphoid cases;