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Physiology of Lactation

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PHYSIOLOGY OF LACTATION

Before lactation

← The female breast is primed by estrogen, progesterone, growth hormone, insulin, thyroid hormone and glucocorticoids.

← These hormones aid in the growth of the ductal system and lobules, and in the development of secretory characteristics of the alveoli.

← Ironically, high levels of estrogen and progesterone also inhibit lactation at receptor sites in the breast tissue.

← The precipitous drop in the levels of these hormones after delivery, in the presence of an elevated prolactin level, facilitates lactation.

Lactation:

← Means – the secretion of milk by the breast (Sweet 1992)

The Physiology of Lactation can be divided into 2 aspects:

1. Lactogenesis – the initiation of lactation

2. The lactation Reflexes

Physiology of Lactation:

1. Lactogenesis / Milk Production

• Following placental separation & expulsion, oestrogen & progesterone levels decreased to the point where prolactin can be released & activated

• Prolactin – secreted by galactophore (milk cell) of the anterior pituitory gland stimulates milk manufacture – increased

• Prolactin now caused the acini cells in the alveoli to produce milk rather than only colostrums

• It functioned to act & select nutrients, water & antibodies from the blood supply around the breast to form milk & will pass through the acini cells droplets by droplets & is collected in the alveoli

• To establish, maintain & increase the milk supply, it is necessary that the baby should suckle frequently at the breast (the more the baby sucks, the more will be the milk production)

• By this nerve impulses is send to the anterior lobe of the pituitary gland & more prolactin is released & therefore more milk is produced

• This is called neurohormonal reflex which is responsible for controlling the milk supply.

Notes:

← Prolactin levels cycle and are highest during sleep.

← Levels in normal nonpregnant women range from 1 to 20 ng per mL (1 to 20 μg per L), depending on the laboratory, and may increase to as high as 300 ng per mL (300 μg per L) during pregnancy.

← Suckling, stress, dehydration, exercise, sexual intercourse and sleep increase the basal secretion rate from the pituitary gland, as do estrogen, thyrotropin-releasing hormone and possibly serotonin.

2. Milk Ejection & Let-Down Reflex

▪ The milk produces is propelled along the lactiferous ducts & some is stored in the ampullae

▪ The baby obtains milk by compressing the ampullae of the breast between his tongue & the hard palate through a peristaltic movement (suckling & clamping the areola & the nipple using tongue & hard palate – by movement of the jaw causing milk to be pushed into the baby’s mouth from the ampullae & swallows the milk)

▪ This milk is called Fore-Milk

▪ The baby’s suckling emptied the ampullae & lactiferous ducts, at the same time stimulates nerves in the nipple to send impulses to the posterior lobe of the pituitary gland causing the release of oxytocin.

▪ Oxytocin caused the myo-epithelial cells surrounding the alveoli contract & milk is squeezed down the lactiferous tubules towards the nipple. This squeezed down of milk is term as the Let-Down Reflex.

▪ This milk which is produced as a result of the nerve impulses & contraction of the myo-epithelial cells is called the Hind-Milk

▪ Because milk is now actively propelled into the ampullae, the baby needs to suck less frequently than at the start of the feeding.

▪ Baby’s suckling rhythm cahnge from rapid to regular, slow deep sucks

▪ Once lactation or production of milk is established, let-down occurs more swiftly & as a conditioned reflex, by which it can also occurs when the mother thinks abour her child or hear a baby’s cry.

▪ The conditioned let-down reflex is indicated by the presence of drip of milk.

The diagram shows four stages:

← Baby's sucking stimulates nerve endings in areola

← Hypothalamus neural reflex (message) is passed to pituitary gland via hypothalamus.

← Posterior Pituitary Oxytocin contracts muscle wall of alveoli to release milk during feeding.

← Anterior Pituitary Prolactin stimulates alveoli to produce breastmilk for future feedings.

[pic]

Summary:

← Maintenance of Lactation - Depend of correct fixing of the baby, demand feeding

← The neonatal reflexes also responsible for this to occur & maintained:

◦ Rooting Reflex

◦ Suckling Reflex

◦ Swallowing Reflex

➢ Desirable factors: motivational mother, knowledge /understanding of the physiology of lactation, ‘adequate’ diet

➢ Undesirable factors: complimentary feeds, conflicting advice, high anxiety – tension on the time of feeding, feeding chart, test weighing (no evidence to support, non-supporting professionalism)

➢ Infection – make sure mother & baby are free.

Practical Application to Midwifery:

← The knowledge & understanding of the anatomy & physiology of breast will help to understand the physiology of lactation

← Understanding of the breast changes in the preparation for the milk production

← Easier to help mothers to breastfeed their babies

← The knowledge can be shared with the mothers so that they will feel confidence & supported with breastfeeding

← Helps & provides mother with clear explanation regarding the establishment of lactation.

REFERENCES

← Edge DS, Segatore M. 1993. Assessment and management of galactorrhea. Nurse Pract. 38,43–4.

← Henschel, D. and Inch, S. (1996). Breastfeeding. A guide for Midwives. United Kingdom; Books For Midwives Press.

← Katznelson L, Klibanski A. 1999. Hyperprolactinemia: physiology and clinical approach. In: Krisht AF, Tindall GT, eds. Pituitary disorders: comprehensive management. Baltimore: Lippincott Williams & Wilkins, 189–98.

← Yazigi RA, Quintero CH, Salameh WA. 1997. Prolactin disorders. Fertil Steril. 67:215–25.

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