...There are at least 15 confirmed 5-hydroxytryptamine (5-HT) receptor subtypes, each encoded by their own distinct genes (Raymond et al., 2001). These subtypes are divided in to seven subfamilies; which are characterized by pharmacological, structural and functional features (Hoyer et al., 1994). The range of 5-HT receptors is further increased by post genomic modifications such as alternative splicing, which can give rise to 10 splice variants for the 5-HT4 receptor and mRNA editing in conjunction with 5-HT2C receptors (Bockaert et al., 2006). 5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6 and 5-HT7 are metabotropic G-protein coupled receptors (GPCRs), whereas 5-HT3 is uniquely ionotropic, (Engleman et al., 2008) (see Fig. 1.) Walstab, J., Rappold, G. and Niesler, B. (2010). 5-HT3 receptors: Role in disease and target of drugs. Pharmacology & Therapeutics, 128(1), pp.146-169. Fig. 1. Schematic of a typical 5-HT3 receptor, showing the cation lumen after the removal of a subunit. Arrows point to reveal the agonistic, competitive, non-competitive antagonists and positive modulators. The orthosteric ligand binding site is magnified to show the binding loops of neighbouring subunits. An arrow also shows the transmembrane (TM) domains of an individual subunit, with TM2 lining the channel pore. A pentemeric receptor consisting of four TM segments to form an intrinsic cation selective, water-filled channel (Barnes et al., 2009). A typical subunit exhibits a large extracellular N-terminus...
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...Nurs Midwifery Stud. 2013 December; 2(4): 77-82. Published online 2013 December 9. Perceptions of Organizational Justice Among Nurses Working in University Hospitals of Shiraz: A Comparison Between General and Specialty Settings Research Article Nahid Hatam , Mozhgan Fardid , Zahra Kavosi 1,* 1,2 1 1Department of Health Management, School of Management and Medical Information Sciences, Shiraz University of Medical Sciences, Shiraz, IR Iran 2Student Research Committee, School of Management and Medical Information Sciences, Shiraz University of Medical Sciences, Shiraz, IR Iran *Corresponding author: Nahid Hatam, Department of Health Management, School of Management and Medical Information Sciences, Diamond Building, Shiraz University of Medical Sciences, 9th alley of Ghasroddasht, Shiraz, IR Iran. Tel.: +98-7112340781, Fax: +98-7112340039, E-mail: hatamn@sums.ac.ir. Received: February 9, 2013; Revised: April 26, 2013; Accepted: July 26, 2013 Background: Justice has gained much attention in social and human studies and has many consequences on employees and the organizations, especially on health system workers such as nurses who are among the key factors in health care systems. Objectives: The purpose of this study was to investigate perception of organizational justice among nurses in educational hospitals of Shiraz University of Medical Sciences (SUMS), and to compare the results of general and specialty hospitals. Materials and Methods: In this research, 400 nurses...
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...Clin Soc Work J (2014) 42:323–335 DOI 10.1007/s10615-014-0496-z ORIGINAL PAPER Trauma Through the Life Cycle: A Review of Current Literature Shulamith Lala Ashenberg Straussner Alexandrea Josephine Calnan • Highlight every key term that refers to the following key concepts: 1) "trauma" generally a) "large T trauma" b) "micro-trauma" 2) "resilience" Published online: 31 May 2014 Ó Springer Science+Business Media New York 2014 Abstract This paper provides an overview of common traumatic events and responses, with a specific focus on the life cycle. It identifies selected ‘‘large T’’ and ‘‘micro’’ traumas encountered during childhood, adulthood and late life, and the concept of resilience. It also identifies the differences in traumatic events and reactions experienced by men compared to women, those related to the experience of immigration, and cross generational transmission of trauma. Descriptions of empirically-supported treatment approaches of traumatized individuals at the different stages of the life cycle are offered. Keywords PTSD Á Large-T and micro-traumas Á Neurobiology Á Gender differences Á Immigrants Á Treatment approaches The past is never dead. It’s not even past. William Faulkner The conflict between the will to deny horrible events and the will to proclaim them aloud is the central dialectic of psychological trauma. Judith Lewis Herman S. L. A. Straussner (&) Silver School of Social Work, New York University, 1 Washington...
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...J Nurs Care Qual Vol. 27, No. 1, pp. 6–12 Copyright c 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Missed Nursing Care, Staffing, and Patient Falls Beatrice J. Kalisch, PhD, RN, FAAN; Dana Tschannen, PhD, RN; Kyung Hee Lee, MPH, RN Patient falls in hospitals continue to be a major and costly problem. This study tested the mediating effect of missed nursing care on the relationship of staffing levels (hours per patient day [HPPD]) and patient falls. The sample was 124 patient units in 11 hospitals. The HPPD was negatively associated with patient falls (r = − 0.36, P < .01), and missed nursing care was found to mediate the relationship between HPPD and patient falls. Key words: falls, missed nursing care, staffing P to 12% of hospitalized patients experience at least 1 fall during their hospital stay.1 A fall is defined as any event in which patients are found on the floor (observed or unobserved) or an unplanned lowering of the patient to the floor by staff or visitors.2 In 2008, and 2010, falls were identified as one of the top 10 sentinel event categories by the Joint Commission.3 Fall rates in hospitals range from 4 to 14 falls per 1000 patient days.4 With the adoption of the Centers of Medicare and Medicaid rule, which no longer reimburses hospitals at the higher diagnosis related group for the care and treatment associated with patient falls that occur during hospitalization, a clearer understanding of what factors U Author Affiliations: School of Nursing...
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...European Journal of Echocardiography (2011) 12, 421–430 doi:10.1093/ejechocard/jeq175 REVIEW Left atrial function: physiology, assessment, and clinical implications Gustavo G. Blume 1, Christopher J. Mcleod 1, Marion E. Barnes 2, James B. Seward 1, Patricia A. Pellikka 1, Paul M. Bastiansen 1, and Teresa S.M. Tsang 2* 1 Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN, USA; and 2Division of Cardiology, University of British Columbia, 2775 Laurel Street, Vancouver, BC, Canada Online publish-ahead-of-print 12 May 2011 The interest in the left atrium (LA) has resurged over the recent years. In the early 1980s, multiple studies were conducted to determine the normal values of LA size. Over the past decade, LA size as an imaging biomarker has been consistently shown to be a powerful predictor of outcomes, including major public health problems such as atrial fibrillation, heart failure, stroke, and death. More recently, functional assessment of the LA has been shown to be, at least as, if not more robust, a marker of cardiovascular outcomes. Current available data suggest that the combined evaluation of LA size and LA function will augment prognostication. The aim of this review is to provide a critical appraisal of current echocardiographic techniques for the assessment of LA function and the implications of such assessment for prediction and disease prevention. ------------------------------------------------------------------...
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...1 1 Fundamentals of Semiconductor Electrochemistry and Photoelectrochemistry Krishnan Rajeshwar The University of Texas at Arlington, Arlington, Texas 1.1 1.2 1.3 1.3.1 1.3.2 1.3.3 1.3.4 1.4 1.4.1 1.4.2 1.4.3 1.5 1.5.1 1.5.2 1.5.3 1.5.4 1.5.5 1.6 1.7 1.7.1 1.7.2 1.7.3 1.7.4 1.7.5 Introduction and Scope . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Electron Energy Levels in Semiconductors and Energy Band Model . The Semiconductor–Electrolyte Interface at Equilibrium . . . . . . . . The Equilibration Process . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The Depletion Layer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mapping of the Semiconductor Band-edge Positions Relative to Solution Redox Levels . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Surface States and Other Complications . . . . . . . . . . . . . . . . . . . Charge Transfer Processes in the Dark . . . . . . . . . . . . . . . . . . . . Current-potential Behavior . . . . . . . . . . . . . . . . . . . . . . . . . . . . Dark Processes Mediated by Surface States or by Space Charge Layer Recombination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Rate-limiting Steps in Charge Transfer Processes in the Dark . . . . . Light Absorption by the Semiconductor Electrode and Carrier Collection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Light Absorption...
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...Vazaskia V. Crockrell-Caldwell Prof. Margaret Griesse T SOC 455: Sociology of Gender 8 December 2014 Domestic Violence in the Lives of Black Women in the U.S. This essay will explore the cause and impact of domestic violence in the lives of black women in the U.S. It will provide general information, such as the definition of domestic violence, statistics, and resources to help survivors leave domestic violence relationships. Following the review of the literature I identify areas which need further research. Since I can remember black women have been characterized as mean and argumentative, but also strong and self-sacrificing for their families. Black families on TV were always portrayed as single mother households. In my community there was also a reoccurring reality of domestic violence against women. This was is in direct contrast to stereotypes I heard about white women, who were portrayed as weak, frail and needing to be protected. Examples include June Cleaver on Leave it to Beaver and the Brady Bunch. But what justified the brutality of domestic violence against black women then and now? In 2011, black females were murdered at a rate more than two and a half times higher than white females: 2.61 per 100,000 versus 0.99 per 100,000. [1] In the U.S. domestic violence against black women has escalated. In 2010, Marissa Alexander an African American woman shot a warning shot at the wall in order to scare Rico Gray, her estranged, abusive...
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...INTRODUCTION Electronic cigarette (e-cigarette) use, or vaping, in the worldwide is increasing. Less than a decade ago, the e-cigarette was an obscure product marketed as a safe, tobacco-free alternative to conventional cigarettes by a single company in China. Seven years ago, the electronic nicotine delivery device entered the US market. Today, health officials, policy makers, and researchers are all scrambling to keep up with a rapidly expanding, wildly controversial, and largely unregulated $3 billion global industry that has, at last count, 466 brands, 7,764 flavors (bubblegum, cherry crush, bacon, java jolt, menthol), and slick, youth-oriented Big Tobacco marketing designed to create the perception that e-cigarettes are not only safe, but cool. Non-nicotine, but an abundant amount of toxic chemicals produced by the combustion of tobacco are the cause of well-known health problems. E-cigarette vapor contains no or only minimal quantities of potentially harmful substances. Hence it can be assumed that vaping in adults is much less harmful than smoking of cigarettes. Furthermore, no data exist that e-cigarettes will encourage youngsters to become cigarette smokers. E-cigarette vaping has the potential to reduce the daily number of cigarettes smoked or facilitates cessation of smoking in heavily nicotine-dependent smokers, who keep on smoking despite a structured smoking cessation program. Health professionals should be aware of this type of nicotine substitution, since the...
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...Journal of Public Health and Epidemiology Vol. 4(5), pp. 117-122, May 2012 Available online at http://www.academicjournals.org/JPHE DOI: 10.5897/JPHE11.194 ISSN 2141-2316 ©2012 Academic Journals Full Length Research Paper Female genital mutilation in Southeast Nigeria: A survey on the current knowledge and practice Ibekwe Perpetus C.*, Onoh Robinson C, Onyebuchi Azubike K., Ezeonu Paul O. and Ibekwe Rosemary O. Department of Obstetrics and Gynaecology, Federal Medical Centre, Abakaliki, Ebonyi State. Accepted 9 April, 2012 Female genital mutilation (FGM) has been recognised as a major reproductive health problem and a dehumanising practice that has resisted change especially in developing countries. The study reviews the current knowledge and practice of FGM in Southeast Nigeria. This is a questionnaire based descriptive study involving women of reproductive age in Abakaliki, South east Nigeria. A semistructured questionnaire was distributed to 320 women by simple random sampling. Information sought included the socio-demographic characteristics, and personal information on FGM with regards to knowledge and practice. Two hundred and sixty (81.3%) were appropriate for analysis. The mean age of the respondents was 28.6 years ± 5.4 SD. Most had formal education, with tertiary education contributing 60.8%. A high percentage was aware of FGM, and the problem associated with it was 91 and 72%, respectively. Half of the respondents (49.6%) were genitally mutilated while almost the...
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...Introduction to Sociology SOC 110 Catalog Description: As an introductory survey of sociology, it is designed to give a broad overview of the field of sociology. It focuses on all aspects of society, culture, social interaction, institutions, group processes, social control, diversity and inequality based on race, ethnicity, class, gender, etc., and the causes and nature of social stability and social change. As a three hour credit course, SOC110 provides the equivalent of 45 hours lecture or classwork. Students are expected to complete an additional 90 hours in homework, study time and completion. (3 credits) Course Objectives: 1. Students will be able to analyze and explain how groups, societies, and cultures address human needs and concerns. 2. Students will be able to describe the importance of cultural unity, diversity, and globalization (NCCS Standards 1.1 and 1.9). 3. Students will be able to understand sociological concepts and apply them in describing the interactions among individuals, groups and institutions (NCCS Standards 1.5 and 1.6). 4. Students will be able to identify and analyze historical change in social institutions, the organization of power, and social movements (NCCS Standards 1.2 and 1.6). 5. Students should be able to explain and apply modes of inquiry drawn from the social sciences in the examination of persistent issues and social problems. Competencies: ▪ The student should be able to define important sociological concepts...
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...Whistleblowing and Ethical Motivations Marie Whitehead Soc. 120 Introduction to Ethics and Social Responsibility Prof: Christopher Messer March 31, 2014 The term whistleblower was first used in England and referred to the practice of British police officers blowing a whistle when a crime was being committed. This would then raise the alarm to other law enforcement officers to alert them that something was endangering the public (Princeton, n.d.). Today, however, the term shares a much broader meaning and is met with a variety of ethical motivations. When we hear the term, “whistleblower”, we know that someone has raised a concern regarding a possible wrongdoing in either a government agency or a private company, and they want to make others aware. The status of the whistleblower is often debated: as Rothschild and Miethe (1999) note, “some see whistleblowers as traitorous violators of organizational loyalty norms; other see whistleblowers as heroic defenders of values considered more important than company loyalty”. In addition, whistleblowing is a “new form of worker resistance” relevant to the “unending battle between labor and management to control the workplace” (Rothschild, et.al, 1999). But with the right motives in place, whistleblowing is good for an organization or agency because it protects that organization and agency from fraud, misconduct, and in most cases, failure. And, when affective communication is in place, the organization’s goals are kept in...
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...THE FUTURE OF EMPLOYMENT: HOW SUSCEPTIBLE ARE JOBS TO COMPUTERISATION?∗ Carl Benedikt Frey† and Michael A. Osborne‡ September 17, 2013 . Abstract We examine how susceptible jobs are to computerisation. To assess this, we begin by implementing a novel methodology to estimate the probability of computerisation for 702 detailed occupations, using a Gaussian process classifier. Based on these estimates, we examine expected impacts of future computerisation on US labour market outcomes, with the primary objective of analysing the number of jobs at risk and the relationship between an occupation’s probability of computerisation, wages and educational attainment. According to our estimates, about 47 percent of total US employment is at risk. We further provide evidence that wages and educational attainment exhibit a strong negative relationship with an occupation’s probability of computerisation. Keywords: Occupational Choice, Technological Change, Wage Inequality, Employment, Skill Demand JEL Classification: E24, J24, J31, J62, O33. We thank the Oxford University Engineering Sciences Department and the Oxford Martin Programme on the Impacts of Future Technology for hosting the “Machines and Employment” Workshop. We are indebted to Stuart Armstrong, Nick Bostrom, Eris Chinellato, Mark Cummins, Daniel Dewey, David Dorn, Alex Flint, Claudia Goldin, John Muellbauer, Vincent Mueller, Paul Newman, Seán Ó hÉigeartaigh, Anders Sandberg, Murray Shanahan, and Keith ...
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...VINCENNES UNIVERSITY CATALOG Vol. LXIX August, 2010 No. 61 A COMPREHENSIVE TWO-YEAR COLLEGE OFFERING ASSOCIATE DEGREES IN THE LIBERAL ARTS, SCIENCES, EDUCATION, ENGINEERING, AND TECHNOLOGY AND OFFERING BACCALAUREATE DEGREES IN SPECIALIZED AREAS Accreditation The North Central Association of Colleges and Schools 30 North LaSalle Street, Suite 2400, Chicago, IL 60602 (312) 263-0456 www.ncacihe.org FAX 312-263-7462 Accreditation Review Council on Education in Surgical Technology and Surgical Assisting American Bar Association American Board of Funeral Service Education American Health Information Management Association Association of Collegiate Business Schools and Programs Commission on Accreditation of Allied Health Educational Programs Commission on Accreditation in Physical Therapy Education Federal Aviation Administration Higher Education Coordinating Board of the State of Washington Indiana State Board of Nursing Joint Review Committee on Education In Radiologic Technology National Alliance of Concurrent Enrollment Partnerships National Association of Schools of Art and Design National Association of Schools of Theatre National League for Nursing Accrediting Commission Printing Industries of America, Inc. Approved for Veterans Membership The American Association of Community Colleges Aviation Technician Education Council The Council of North Central Two Year Colleges The Higher Education Transfer Alliance The National Academic Advising Association The North Central Association...
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...IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, VOL. 5, NO. 4, JULY/AUGUST 1999 1205 Optical Coherence Tomography (OCT): A Review Joseph M. Schmitt (Invited Paper) Abstract— This paper reviews the state of the art of optical coherence tomography (OCT), an interferometric imaging technique that provides cross-sectional views of the subsurface microstructure of biological tissue. Following a discussion of the basic theory of OCT, an overview of the issues involved in the design of the main components of OCT systems is presented. The review concludes by introducing new imaging modes being developed to extract additional diagnostic information. Index Terms— Imaging, interferometry, optical coherence tomography, speckle. I. INTRODUCTION HE APPLICATION of optical technology in medicine and biology has a long and distinguished history. Since the 18th century, the microscope has been an indispensable tool of biologists. With the invention of the laser in the early 1960’s, physicians gained a new surgical instrument. The development of fiber optics led to the manufacture of endoscopes that permit direct viewing of internal organs deep in the body. In the modern clinical laboratory, new optical technologies facilitate the chemical analysis of tissue samples and the counting and sizing of blood cells. In spite of these and other advances, few of the optical instruments used in medicine today take advantage of the coherent properties of light. Even most instruments that...
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...Op-Ed Who pays the bill and who makes the profit in treating chronic disease? .............................. Lack of financial incentives means prevention is often ignored John Roberts Bellingham, WA 98226 Correspondence to: Dr Roberts jcroberts@hinet.org “A courtyard common to all will be swept by none” goes a Chinese proverb. Sadly, this ancient saying remains true in the modern American medical system. At the start of the third millennium of Western culture and progress, the suffering of medical illness arguably may be higher than in the centuries past. Until the last 50 years, illness—often combined with poverty—was a greater shortener of lives. But death, compared with today, came more quickly. In practice, an internist sees the local viewpoint of national statistics: 90 million Americans alive with chronic disease who spend more than 60% of the country’s health care budget.1 Of the 20 or so patients that many physicians see each day, one, maybe two, might not have a chronic disease. Almost every one of these patients has needs far beyond what a doctor can provide. And much of the reason is inferred from two questions: “Who pays the bill?” and “Who makes the profit?” At a policy level, the “epidemic” of chronic illness is as much a philosophical debate as it is a medical problem. If people live longer, they get illnesses of aging—dementia, loss of vision and hearing, organ failure, and cancers. In addition, chronic illness today may not...
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