... Stem cell therapy Irfan manzoor. Roll no: RP7002B22. Reg. no: 11000225. Course: Bsc. Biotech 1. Lovely professional university Contents 1. Stem cells and properties. 2-3 2. Stem cell therapy. 5-12 3. Stem cell use in animals 13-15 4. Recent researches in stem cell therapy 16-19 5. Conclusion 21 6. Bibliography 22 Stem cells Stem cells are cells found in all multi cellular organisms. They are characterized by the ability to renew themselves through mitotic cell division and differentiate into a diverse range of specialized cell types. Research in the stem cell field grew out of findings by Ernest A. McCulloch and James E. Till at the University of Toronto in the 1960s. The two broad types of mammalian stem cells are: embryonic stem cells that are isolated from the inner cell mass of blastocysts, and adult stem cells that are found in adult tissues. In a developing embryo, stem cells can differentiate...
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...Jody Vaughn Research Draft Since the discovery of stem cell therapy, it has been a controversial topic of long debate of moral ethics and politically. The discovery of stem cells and their ability to generate new cells began in the 1800’s. Today the topic of research therapy makes headlines with its controversy with the use of embryonic stem cells. Historically stem cell research includes plant, animals and human stem cells but today the prominent use of stem cells in humans is bone marrow transplant. This has become a simple one day medical procedure that is one of a lesser debate. Complete strangers can now simply be tested for a compatible match to an awaiting recipient. This type of success has brought stem cell to the forefront of medical researches discovery of other stem cell therapies that are futuristic in nature and have the possible to cure devastating disease and injuries that would otherwise leave someone completely debilitated or worse. Stem cell therapy is on the verge of being a revolutionary medical advancement in history. The discovery that stem cells could generate new healthy cells in the 1800’s had revolutionized the medical profession. Blood marrow transplant are the front runner of the success that stem cells can produce. This is the prominent force that guides researcher to believe that stem cells can be a cure for many diseases such as Parkinson’s disease, immune deficiency disease, certain types of leukemia’s, severe blood disorders and traumatic...
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...Stem Cell Research Stem cell research has played a vital role in modern-day society. This research has done many things that will change mankind forever. How can stem cell research be explained and described? Furthermore, there are many benefits of stem cell research, and unfortunately, there are many disadvantages of this research. Additionally, this has caused many ethical debates of whether the use of stem cell research is right or wrong. All of these statements and questions will determine how stem cell research shapes the future. To begin, how can stem cell research be explained and described? In this type of research, people discover how to fix imperfect tissues. Additionally, researchers study how embryonic stem cells can develop into many different types of tissues. Stem cell research began when Jamie Thomson and a group of people from a college made the first embryonic stem cell. Because of him and his team, the research has developed into something even larger. Now, stem cell therapy is used to treat many diseases such as diabetes, and Parkinson’s disease. “It had long been believed that adult tissue does not...
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...The Trials of Stem Cell Therapy Stem Cells: Plenty of Hope, but Halting Progress By KAREN WEINTRAUBSEPT. 15, 2014 Photo Embryonic stem cells, from a woman with Type 1 diabetes, were induced to turn into insulin-making beta cells, in hopes they could be implanted to cure the disease. Credit Bjarki Johannesson/New York Stem Cell Foundation, via Reuters Edgar Irastorza was just 31 when his heart stopped beating in October 2008. A Miami property manager, break-dancer and former high school wrestler, Mr. Irastorza had recently gained weight as his wife’s third pregnancy progressed. “I kind of got pregnant, too,” he said. During a workout one day, he felt short of breath and insisted that friends rush him to the hospital. Minutes later, his pulse flatlined. He survived the heart attack, but the scar tissue that resulted cut his heart’s pumping ability by a third. He couldn’t pick up his children. He couldn’t dance. He fell asleep every night wondering if he would wake up in the morning. Desperation motivated Mr. Irastorza to volunteer for a highly unusual medical research trial: getting stem cells injected directly into his heart. “I just trusted my doctors and the science behind it, and said, ‘This is my only chance,’ ” he said recently. Over the last five years, by studying stem cells in lab dishes, test animals and intrepid patients like Mr. Irastorza, researchers have brought the vague, grandiose promises of stem cell therapies closer to reality. Photo Edgar...
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...U.S Stem Cell Industry Management of Technology - MGMT 620 (EMBA) Professor – Dr. Gopalakrishnan Norman Cousar Draft Version 3 December 16, 2011 Due to previous government regulations, US companies have not used embryos for stem cell research, and international companies have gained a first mover advantage in commercializing stem cell treatments and therapies. The use of stem cells has opened up a new field called regenerative medicine or cell therapy, which replaces damaged or diseased cells that are in the body with new ones. Stem cells have the ability to develop into many different cell types within the body during the early life and growth cycle. Stem cells repair internal system, by dividing and replenishing other cells. They distinguish themselves by being unspecialized cells, renewing themselves through cell division and under certain physiologic conditions, be chemically induced to become tissue or organ-specific cells with particular functions. There are several different types of Stem Cells: Embryonic Stem Cells (hES), which are derived from embryos, mostly from eggs fertilized in vitro and donated for research with the donor’s permission. Adult Stem Cells (hES), are undifferentiated cells found among differentiated cells in tissue and organs, which can differentiate themselves to yield some or all of the major specialized cell types of that tissue or organ. iPSC Stem Cells: Are also adult cells, genetically reprogrammed to an embryonic stem-cell like...
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... Baylois Francois, Grass Kathleen, (2006) “Stem cell trials: Lessons from gene transfer research”, 23-26. When I first heard of stem cell research I wondered how the government could refuse Stem cell research, something that holds the cure for diseases like Alzheimer’s , Cancer or even HIV/AIDS. I didn’t know the background story and how stem cell research borders on the morality of what is ethical and what isn’t. Is it acceptable to save one life but kill another? The critics and the religious minded who believe life begins at conception see this as murder, while proponents praise it as innovative and groundbreaking, in helping save millions of lives. This Cutting-edge new experiment challenges and goes against numerous religions that oppose killing human life, which makes it so controversial. The issue of stem cell research largely involves the destruction of five to seven year old embryos, and raises the morality of this experiment. It questions our principals and makes us wonder are we really sacrificing a life or saving one? You have to choose between two wrong things. While there is immense excitement among scientists and people of the possibility of the millions of human lives stem cells can save there is also a great safety concern as well. Stem cell research has always been a very relevant topic. Over the last decade politicians, Scientists and theorists have debated on the medical advancement of stem cell research, its regenerative medicine and the remarkable...
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...Shelley Gouin November 10th, 2015 Persuasive Speech/ Stem cell research I. Introduction A.Attention: Did you ever wonder if our generation could ever cure cancer or even give a paraplegic a chance to walk again? Stem cells could be the real answer to these questions. Stem cells are reproductive cells that adopt the qualities of the tissue that it is surrounded by, therefore becoming a part of the tissue itself. B. Thesis statement: Stem cell research has generated new information about basic cell system that is critical to understanding the causes of disease, such as cancer. C. Preview: The state of California has become a world leader in stem cell research. According to the California Institute for Regenerative Medicine, stem cell research has the potential to also treat diseases that are currently burdened with high health care costs. These specific diseases include heart disease, Alzheimer’s disease, or diabetes. II. Body A. If stem cell therapy becomes a cure for these diseases it would cripple the healthcare system. Even if stem cell therapy doesn’t entirely cure a disease, reducing its impact would be a massive economic benefit. 1. Most therapies would allow individuals to go back to work. a. This would also allow the caregivers for these individuals to go back to work again. 2. Stem cell research is expected to boom in the biotech industry, bringing new companies to the state of California and creating high paying jobs. a. Individuals states have passed...
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...Stem cell research is a massive topic of discussion within many groups of people around the world. Whether it is right or wrong is the question, however in stem cell research there is no such thing as wrong. People are usually against stem cell research because they are also against abortion and there are horror stories of the experiences patients and pathologists have had with abortion. People believe that stem cell research gets embryonic stem cells from an abortion clinic what an abortion clinic does with the fetuses is either send them to a pathology facility or they just throw them away in the trash. Stem cell research does not use aborted fetuses or embryos for collection of embryonic stem cells. The People against the idea of Embryonic...
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...STEM CELL & CELL CULTURE Differences between embryonic and adult stem cells. One of the differences between embryonic and adult stem cells is the cell potency. Cell potency comes from the term potential and basically means a cells’ potential to differentiate and take on different functions. Embryonic stem cells are pluripotent and thus can form all types of cells (endoderm, mesoderm, and ectoderm). Adult stem cells on the other hand are mostly multipotent, meaning the cells can only differentiate to different cell types from the same tissue of origin. For instance, blood stem cells can differentiate into many different type of blood cells but cannot differentiate to become muscle or neuron cells. To put it simply, adult stem cell are more specialized (focused on a particular tissue lineage) whereas, embryonic stem cells are more versatile. (Stem Cell Research- Pros and Cons, Date retrieved: 17th September 2011) Another difference between adult stem cells and embryonic stem cells is the ease of culturing these cells. It is significantly easier to cultivate embryonic stem cells in comparison to adult stem cells. Adult stem cells are hard to isolate in mature tissue and have a hard time surviving past a few generations during the in-vitro culturing. Considering stem cell therapy requires a large amount cells, embryonic stem cells are a more feasible alternative as they can grow rather easily in the lab. (Stem Cell Information, Date retrieved: 20th September 2011) However...
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...aren’t sure about being a candidate for stem cell treatment. I have done a bit of research to help you understand the possibilities about being treated with stem cells. I want you to know the pros and cons of the treatment to hopefully help you decide on the best course of action for your injuries. I want you to get better and hope this helps you! Scientists throughout the years have been on the front lines of development for the treatment of diseases, disorders, and injuries for several hundred years now. Until recently stem cell therapy has been a thing of science fiction. But for over 30 years bone marrow has been used to treat cancer, leukemia, and lymphoma. This actually is a form of stem cell therapy that has been used...
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...Stem Cells as a Treatment Overview: Stem cell research is a highly promising field of study. Its most important applications include medicine and therapy. These will be the focus of this paper. To begin: an overview of stem cells, alternatives to embryonic stem cells, and recent advances. Stem cells are amazing for their capacity for self-renewal and, most of all, the ability to become any of millions of cell types in the human body. There are various types of stem cells, each with different potential. This includes embryonic stem cells. These totipotent cell lines come from the inside of the cell mass of a human embryo. These embryos are taken specifically from fertilized eggs not used by in-vitro fertilization (1). At this point, they are just a blastocyst, meaning an embryo composed of approximately one hundred cells. The cells on the inside of the blastocyst are undifferentiated but eventually will multiply and differentiate extensively to make all of the different required cells. Adult stem cells cells also have this same ability. They are found throughout the body and are able to dived to replenish dying cells and regenerate damaged tissues (1). Adult stem cells are able to renew themselves and create a variety of cells, but are usually multipotent, meaning that they only are able to specialize into a small selection of cells. ‘Totipotent’ stem cells can be transformed into any type of cell in the human body, however, there is a great amount of controversy...
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...Regenerative Therapy Omar Saeed Nicholas Justus Date Due: April 7th, 2013 Stem Cells are specific biological cells found in organisms that contain the ability to divide, differentiate and regenerate to create further stem cells. Stem cells divide through mitosis and differentiate by a specific process, which allows the cell to become a more specific cell type. Stem cells therapy as a whole is a very debated and controversial topic as it brings about ethical and moral dilemmas involving the conception, treatment and fatality of human embryos included in the research of stem cells. This therapy introduces new stem cells into damaged tissues as the cells have the ability to self-renew and in most situations alleviate any disease or damage in the body. Since this subject matter brings about such debate and discussion it is necessary that this topic is addressed and handled. Stem cells relate very intimately with class material as it involves the cells ability to divide and differentiate, both crucial and significant topics in the class because it deals with mitosis, specialization and cell function. With the diverse range of functions stem cell research encompasses, it is only a matter of time before stem cell use, research and therapy can no longer be ignored but used to treat and alleviate distressed patients around the world. The New York Times article “Sickle Cell Transplants Could See Wider Use” expressed how sickle cell disease, a debilitating genetic disorder, could...
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...May 6, 2013 DNA Technology INTRO – LEE DNA Technology: Cloning, Gene Therapy, and Stem Cell Research DNA technology encompasses a wide variety of applications and because of the duplicating nature of DNA, it is easy to see how humans could benefit from its manipulation. One such technology is cloning. Cloning technology comes in three forms: recombinant DNA cloning, reproductive cloning, and therapeutic cloning. Cloning Recombinant DNA cloning consists of transferring DNA fragments from an organism to a self-replicating element, like a bacterial plasmid. The fragments join with the cloning vector and are reproduced with the host cell. This technology is most commonly known for its use in genetically modified foods. DNA fragments that code for better tasting, higher nutrient qualities are spliced into regular plants to produce super foods (US Dept of Energy Genome Program, 2009). Reproductive cloning takes all the genetic information out of a cell and replaces it with DNA from the desired organism. With luck, this cell will begin to divide until it becomes an embryo and can be implanted into a host mother (US Dept of Energy Genome Program, 2009). Gene Therapy and Stem Cell Research Therapeutic cloning is by far the most controversial. This type of cloning produces human embryos for use in research, and usually for the stem cells that can be harvested from these embryos. Stem cells can be used to clone organs and body parts from the patient’s own DNA to eliminate...
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...Stem cell research is one that is widely debated amongst various religions, cultures, and political groups. The question as to when life actually begins is the epicenter of this worldwide quarrel, and may not be settled for some time. Although this may be true, one fact that cannot be denied is that stem cell research has led to many life saving discoveries in various sectors of scientific research. In regards to the ethical dilemma of stem cells, recent developments in induced pluripotent stem cells (iPSCs) have made it possible to explore the applications of stem cells while avoiding the ethical problems associated with embryonic stem cell research (Seki & Fekuda, 2015). One intriguing area in stem cell research is the potential applications for them in the treatment of cardiac diseases. Studies have explored the potential uses for stem cells for the treatment of heart disease (Yamakawa & Ieda, 2015). Additionally, stem cells have been explored for the treatment of heart failure and myocardial infarction (Rasmussen, et al., 2013). Stem cells and how they may be used for the treatment of various cardiac diseases is an exciting topic and has the potential to change future approaches to the treatment. This paper will examine the applications and significance of stem cells in relation to these common cardiac pathologies. Heart disease is one of the leading causes of death in developed countries and currently there are few effective treatment options available (Yamakawa & Ieda...
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... Adult stem cell research on humans began in the 1960's, first achieving success in the treatment of a patient with severe combined immunodeficiency disorder in 1968. Since the early 1970's, adult stem cells have been successfully used for treatment of immunodeficiencies and leukemias The issue of stem cell research, particularly embryonic stem cell research, became a high-profile political issue in the U.S. during the first year of President George W. Bush's term in office (2001). On August 9, 2001, Bush enacted a ban on federal spending for the purpose of deriving new embryonic stem cells from fertilized embryos. He argued that performing research on embryos is destroying human life, and should therefore be avoided. Both the 109th and 110th Congresses passed bills overturning the ban, but both were vetoed by Bush. During the 109th Congress, both houses also passed and Bush signed a bill banning the creation of human fetuses with the sole purpose of destroying them and harvesting their body parts. The Senate also passed a bill encouraging research into the creation of stem cell lines without destroying human embryos. The controversy is that embryonic stem cell research (ESCR) is not pro-life. It gives false promises to patients while killing a human embryo. It is dead end research. ESCR has cured no disease nor successfully treated anyone. ESCR has not gone beyond research on lab animals. ESCR produces tissue rejection and unstable deadly tumors. Research advocates...
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