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Tourette Syndrome

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Tourettes is a genetic disorder that affects everyday life for those who suffer from it. Tourettes was discovered by Gilles de la Tourette in 1885, who was a French physician. Originally 8 patients diagnosed with Tourette’s with symptoms ranging from verbal tics, shouting of words, repeating of words and mimicking others gestures. Tourettes is classified as a complex neuropsychiatric disorder which takes place within basal ganglia and the frontal cortical circuits of the brain. Suffers with Tourettes experience involuntary tics, movements, and vocalizations. Surprisingly, Tourette Syndrome affects more men than women and many patients compare a tic to the urge to sneeze or cough. Patients between the ages of 6 and 40 are more likely to get Tourette’s, and the media commonly calls Tourette …show more content…
The first gene suspected of being involved is the SLITRK1 gene. This gene provides instructions for making a protein that is active in the brain, it also plays a role in the development of nerve cells that allow each nerve cell to communicate with nearby cells. Despite this, it is unclear how mutations in the SLITRK1 gene can lead to this disorder. The cytogenetic location of the SLITRK1 gene is 13q31.1 which means that it is located on the long arm of chromosome 13 at position 31.1. The second gene involved in Tourette's is the IMMP2L gene which is in the inner mitochondrial membrane peptidase, subunit 2. This gene affects the brain with intragenic deletions affecting two alternative transcripts. IMMP2L gene is located at the cytogenetic location 7q31 which means it is found on chromosome 7 at position 31. Symptoms of Tourette’s include verbal tics, shouting of words, repeating the words of others, and mimicking others’

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