In the past decade, researches in mitochondrial dynamics have unveiled that defects in the key features of mitochondria, such as fusion, ssion, transport and mitophagy are associated with neurodegenerative diseases [8], [9], [10]. Remarkably, in several disease models, the manipulation of mitochondrial fusion or ssion can partially rescue disease phenotypes[7].
Mitochondria's structure contains two distinct membranes, an inner one and an outer one and two internal compartments[11]. The structure of mitochondrial membranes is linked to the metabolic state of mitochondria [12]. The proper functionality of mitochondria is vital since they are responsible for the production of adenosine triphosphate (ATP), the cellular energy source. Mitochondrial