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Adrenal Gland

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The adrenal gland is a structure that is located above each of the kidneys, consisting of an outer cortex and an inner medulla. The adrenal cortex is responsible for the synthesis of steroid hormones, including glucocorticoids and mineralocorticoids. Whereas, the adrenal medulla produces amines, including epinephrine and norepinephrine. The synthesis of glucocorticoids is mediated by the hypothalamus and pituitary gland, whereas Mineralocorticoids are mediated by by the kidney and the adrenal medulla hormones are triggered by the sympathetic nervous system during stress. When the corticotrophin-releasing hormone (CRH) is released from the hypothalamus, it triggers the production of adrenal corticotrophic hormone (ACTH) from the pituitary gland. …show more content…
This rhythm defines the fluctuation of the glucocorticoid levels in the blood reaching a peak through the active phase of the day. This process is regulated by the circadian clock, which is a biological time keeper that is responsible for alerting the organism about the various variations in the environment. The circadian production of the glucocorticoid is thought to be through a central pacemaker in the suprachiasmatic nucleus of the hypothalamus and circadian clock in the adrenal gland. Therefore, the regulation of this rhythm is accomplished by the autonomic nervous system and the hypothalamic-pituitary-adrenal axis. On the other hand, the regulation of the gland’s sensitivity to the ACTH is mediated by the circadian clock of the adrenal gland. The normally existing glucocorticoid in humans is cortisol (van der velden., 1998). Cortisol is derived from inactive cortisone through 11β-hydroxysteroid dehydrogenase isozyme type1 (11βHSD1). Glucocorticoid is regulated through the glucocorticoid receptor (GR) whereas, mineralocorticoid is regulated through the mineralocorticoid receptor (MR). These two receptors are similar in structure and are expressed in many tissues. MR has high affinity to cortisol, corticosterone and aldosterone. In the majority of the tissues at the basil levels glucocorticoid stimulate MR, whereas GR is activated by glucocorticoid when at stress levels. In this paper we are mainly concentrating on glucocorticoids. Glucocorticoids are known for their beneficial roles including anti-inflammatory and immunosuppressive. An example for its anti-inflammatory affect is the usage of glucocorticoid for the treatment of bronchial asthma. The glucocortecoid treatment of asthma was first introduced in the 1950. The anti-inflammatory effects of glucocorticoids are thought to be mediated by an anti-inflammatory protein called

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