The average weights for all prepared formulations were uniform and ranged (160.29-183.02) mg, All the captopril buccal patch showed an acceptable thickness(0.246-0.273 ) mm and the surface pH value (6.32-6.53) , when compared to that pH of oral mucosa indicating that it doesn't cause un irritation to buccal mucosa, table 2. Content uniformity
The formulated captopril buccal patch showed acceptable quantity of medicament ranged from (95.27-104.54%). This result met the accepted range of content uniformly labeled in BP which is ranged from 85% to 115% . According to that , captopril was spread uniformly throughout the 4 cm2 constant area of buccal patch. as seen in table 2
Table(2):- Result of physical Evolution Parameters of Prepared Captopril …show more content…
F2 166.38±3.08 0.256±0.031 6.32±0.07 104.54±0.003
F3 183.02±1.33 0.273±0.046 6.43±0.12 100.06±0.014
F4 164.45±7.81 0.263±0.012 6.44±0.21 96.12±0.053
F5 168.33±5.12 0.266±0.009 6.38±0.05 95.39±0.042
F6 170.53±2.2 0.272±0.05 6.53±0.11 99.15±0.033 Mechanical Properties of Prepared Captopril Mucoadhesive Buccal …show more content…
Formula F3 (PEG 400 as plasticizer) showed a significant increase (P<0.05) in drug release than other plasticizer, this may due to PG increase the partition coefficient and so that increasing drug diffusion [25]. , also it was found that the higher loading of captopril, the greater amount of drug would dissolve inside the hydrated polymer matrix leading to increasing the drug diffusion rate and release [29].

Figure 2: Effect of plasticizer type on in-vitro release of captopril in phosphate buffer pH6.8 at 37 from mucoadhesive buccal patches. Figure 3:-Effect of increasing of drug amount on in-vitro release of captopril in phosphate buffer pH6.8 at 37 from mucoadhesive buccal patches.

Determination of Selected Formula of Captopril Mucoadhesive Buccal Patch
Formula F4 was selected for further investigation and the selectivity was made since the patch had accepted value for mechanical properties(16.06MPa, 34.14%) ,surface PH(6.44±0.21), convenient mucoadhesive strength(26.2±0.256) and suitable ex-vivo time (6.12±0.06)hrs with high drug release 94.73% for