...the most deadly form of skin cancer. Advanced metastatic melanoma, stage III or IV, has been incurable and relatively untreatable with “less than 10% of patients responding to traditional chemotherapy” regimens (PubMed Health, 2011). Progress in this area of oncology research has been very slow with the “average prognosis for patients with stage IV metastatic melanoma being 8-18 months” (Chapman., 2011). Proven research shows that the standard chemotherapy regimens don’t actually extend the lives of these patients. The standard first line treatment for late stage metastatic melanoma is dacarbazine (DTIC), used either alone as a single agent or in combination with other chemotherapy agents, and the effects have been minimal. The dacarbazine regimen usually shrinks the tumors for a temporary period, “about 3-6 months,” and then they begin to grow again. (Melanoma Skin Cancer, 2011). Recent research in the past five years has led to some targeted immunotherapy drugs like ipilimumab and peginterferon alpha-2b which have shown some promising results in helping to extend life expectancies for these patients. On August 17, 2011 the Food and Drug Administration gave some much needed hope to these patients with the approval of vemurafenib (Zelboraf). An orally administered targeted chemotherapy agent that has shown statistically significant results in “reducing the risk of the persons illness progressing and improved short term survival rates” of people with metastatic melanoma who...
Words: 1737 - Pages: 7
...technology in a mammalian cell (Chinese Hamster Ovary) culture containing the antibiotic gentamicin. Gentamicin is not detectable in the final product. Herceptin is a sterile, white to pale yellow, preservative-free lyophilized powder for intravenous administration. Each multi-use vial of Herceptin contains 440 mg trastuzumab, 400 mg α, α-trehalose dihydrate, 9.9 mg L-histidine HCl, 6.4 mg L-histidine, and 1.8 mg polysorbate 20, USP. Reconstitution with 20 mL of the appropriate diluent...
Words: 1707 - Pages: 7
...00 DOI: 10.10170S1478951506060494 Requests for euthanasia and physician-assisted suicide and the availability and application of palliative options MARIJKE C. JANSEN-VAN DER WEIDE, M.SC., BREGJE D. ONWUTEAKA-PHILIPSEN, PH.D., AND GERRIT VAN DER WAL, PH.D., M.D. Department of Public and Occupational Health and Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands ~RECEIVED June 5, 2006; ACCEPTED August 27, 2006! ABSTRACT Objective: This study investigated the palliative options available when a patient requested euthanasia or physician-assisted suicide ~EAS!, the extent to which the options were applied, and changes in the patient’s wishes. Methods: In an observational study, 3614 general practitioners ~GPs! filled in a questionnaire and described their most recent request for EAS ~if any! ~n 1,681!. Results: Palliative options were still available in 25% of cases. In these cases options were applied in 63%; in 46% of these cases patients withdrew their request. Medication other than antibiotics, which was most frequently mentioned as a palliative option ~67%!, and applied most frequently ~79%!, together with radiotherapy, most frequently resulted in patients withdrawing their request. Significance of results: GPs include the availability of palliative options in their decision making when considering EAS. The fact that not all options are applied or, if applied, the patient persists in the request is related to autonomy...
Words: 5014 - Pages: 21
...diagnosed with Hypokalemia, obstructive Uropathy, Anaemia and Likely Cervical Cancer. A biopsy confirmed Cervical Cancer Stage III B and bilateral Nephrostomy tubes were ordered and inserted to aid the client in eliminating wastes from here body. With the administration of the IV Lasix 40 mg and Nifedipine 10 mg po there was a significant improvement in the client’s blood pressure readings 149/96 122/82. However, there was still no urinary output of significance. There should have been increased urinary output due to the therapeutic action of this loop diuretic. The administering of the loop diuretic, cocktail (100cc 50% Dextrose, 20 cc of calcium gluconate and 20 units of soluble insulin) and the insertion of the nephrostomy tubes improved the clients potassium reading from a 7.6 to a 5.8mEq/l. Normal potassium level range between 3.5-5.0. The potassium level in the blood was still elevated thus Kayexalate 15g po tds was added to the regime. This antihyperkalemic drug releases sodium ions in exchange primarily for potassium ions and ultimately expels potassium from the body via the intestines (Deglin, Vallerand & Sanoski, 2014). With the nephrostomy tubes institu, there was improved in the electrolyte balance of the client. A study conducted by Mishra, Desai, Patel, Mankad and Dave (2009) saw the correlation between advanced cervical cancer and obstructive Uropathy and the need for insertion of percutaneous nephrostomy...
Words: 901 - Pages: 4
...AND II IN SPECIALTY AREA COURSE CODE: NUR 822S and NUR 829S PATIENT / FAMILY CASE STUDY (A NURSING PROCESS APPROACH) ON A CLIENT WITH GESTATIONAL TROPHOBLASTIC NEOPLASM BY: CHARLOTTE LAMPTEY SN/ADN/15/0030 AUGUST, 2016 CONTENTS * PREFACE * ACKNOWLEDGEMENT * INTRODUCTION CHAPTER ONE: OVERVIEW OF CLIENT SITUATION I. Literature review of gestational trophoblastic neoplasm CHAPTER TWO: COMPREHENSIVE HOLISTIC ASSESSMENT OF PATIENT/FAMILY I. Patient’s medical and personal history including review of the systems II.Physical examination III.Diagnostic evaluation IV.Nutritional assessment V. Psychosocial history VI. Patient developmental assessment VII.Spiritual assessment VIII.Quality of life assessment IX.Admission of patient CHAPTER THREE: ANALYSIS OF DATA CHAPTER FOUR: COLLABORATIVE PLAN OF CARE I. Presumptive medical diagnosis II.Nursing diagnosis III.Evidence-based interventions IV.Additional diagnostic procedures warranted but not done Medication to be ordered CHAPTER FIVE: DISCHARGE PLAN I. Community service and resource needed II.Client education plan III.Plans for follow-up of care CHAPTER SIX: EVALUATION PLAN Termination of care * SUMMARY * CONCLUSION * REFERENCE PREFACE The patient / family care study is an essential and relevant study undertaken on the patient and the family by a final year nursing student as part of the required curriculum...
Words: 17052 - Pages: 69
...de Souza et al. BMC Health Services Research 2012, 12:481 http://www.biomedcentral.com/1472-6963/12/481 RESEARCH ARTICLE Open Access Unsupported off-label chemotherapy in metastatic colon cancer Jonas A de Souza1,2*, Blase Polite1,2,3, Monica Perkins4, Neal J Meropol5, Mark J Ratain1,2,6, Lee N Newcomer4 and G Caleb Alexander7 Abstract Background: Newer systemic therapies have the potential to decrease morbidity and mortality from metastatic colorectal cancer, yet such therapies are costly and have side effects. Little is known about their non-evidence-based use. Methods: We conducted a retrospective cohort study using commercial insurance claims from UnitedHealthcare, and identified incident cases of metastatic colon cancer (mCC) from July 2007 through April 2010. We evaluated the use of three regimens with recommendations against their use in the National Comprehensive Cancer Center Network Guidelines, a commonly used standard of care: 1) bevacizumab beyond progression; 2) single agent capecitabine as a salvage therapy after failure on a fluoropyridimidine-containing regimen; 3) panitumumab or cetuximab after progression on a prior epidermal growth factor receptor antibody. We performed sensitivity analyses of key assumptions regarding cohort selection. Costs from a payer perspective were estimated using the average sales price for the entire duration and based on the number of claims. Results: A total of 7642 patients with incident colon cancer were identified...
Words: 5524 - Pages: 23
...shifting to a system which the costs of drugs, tests, and other care are combined in a single-provider payment,” researchers said. Patients concerns about out-of-pocket payments made patients decide how to treat their cancer. Patients that have health insurance have used most or all of their savings to treat their cancer. “We’ve made progress in cancer research, but people are still dying at too high a rate,” (Gibson, 2010). Projected Costs of Cancer Treatment In The US 2010-2020 What Are The Different Types of Cancer Treatments? Surgery, chemotherapy, and radiation treatment are the most common types of cancer treatment. The first treatment option that doctors consider using...
Words: 841 - Pages: 4
...Non-Small-Cell Lung Cancer Lung cancer, the most preventable cancer, it is the leading cause of cancer-related deaths in men and women in Canada. In 2008, it was estimated that there would be 23,900 new cases (12,600 men and 11,300 women) of lung cancer in Canada and that there would be 20,200 deaths (11,000 men and 9200 women) from lung cancer in Canada (Lewis, Heitkemper McLean, Dirksen Ruff, O’Brien Graber, & Bucher). Non-small-cell lung cancer (NSCLC) is a term for different types of lung cancers that have different types of cancer cells that grow and spread in their own way. NSCLC accounts for 80-85% of all lung cancer cases and includes squamous cell carcinoma, adenocarcinoma, and large cell carcinoma (Gutierrez-Cabezon & et al. 2012), which are the most common types of non-small-cell lung cancer. There are some rare types of NSCLC but the purpose of this essay is to cover the most common types of non-small-cell lung cancer. Overview of Non-small-cell Lung Cancer Squamous cell (epidermoid) carcinoma is closely correlated to smoking and environmental carcinogens such as “asbestos, radon, nickel, iron and iron oxides, uranium, polycyclic aromatic hydrocarbons, chromates arsenic, and air pollution” (Lewis et al., 2010). The squamous cell carcinoma tends to originate in the central bronchi as an intraluminal growth and is thus more amendable to early detection through cytologic examination of sputum than other forms of lung cancer (Hannon, Pooler & Porth)...
Words: 3661 - Pages: 15
...Running head: Associate and Baccalaureate-Degree Registered Nurses Associate and Baccalaureate-Degree Registered Nurses: Differences in Competencies R B S Grand Canyon University: NRS 430V 10 July 2011 There are two ways to become a registered nurse: a fast track two year associate degree course or a comprehensive four year baccalaureate course. A graduate of both courses makes the student qualified to take the NCLEX-RN and get an RN license. The American Association of Colleges of Nursing (2010) believes that “education has a significant impact on the knowledge and competencies of nurses”. The healthcare environment and the nursing world today are constantly changing. The economy is getting worse and competition is getting fiercer. As a result there is an escalating demand for better-quality and efficient patient care providers and independent decision making nurses. The registered nurse today is expected to do much more than just follow physician’s orders, administer medications on time and wound dressing changes. The nurse nowadays must be able to make important judgment decisions, must be able to politely query a doctor when orders seem not appropriate and help patients and family members make difficult decisions that will affect their lives. The associate degree RN and the bachelor’s degree RN have the same RN license, but the baccalaureate degree nurse studied more subjects in the physical and social...
Words: 1084 - Pages: 5
...Global Leprosy In 1978, NIAID awarded two contracts for the purpose of fractionating Mycobacterium leprae-infected armadillo organs to derive sizable quantities of M. leprae for use by the leprosy research community. Dr. Brennan's program at National Jewish Hospital was awarded one of the two contracts. Upon Dr. Brennan's transfer to Colorado State University in 1980, the work moved there. Thus, we have had this contract since 1979 through five subsequent recompetitions. Since the closing of the WHO/IMMLEP M. leprae Bank in 1990, this Contract is now the sole source of appreciable quantities of M. leprae and its various products. Prior to 1995, two contracts existed, "Isolation, Purification and Characterization of Antigens from Purified Mycobacterium leprae Obtained from Armadillo Tissue" at CSU and "Establishment and Maintenance of an Armadillo Colony Infected with M. leprae" at Florida Institute of Technology, Melbourne, FL, under Dr. Eleanor E. Storrs and, later, Dr. A. Dhople. In 1995, one contract in two parts was announced, and the Gillis W. Long Hansen's Disease Center, Carville/Louisiana State University (Dr. Richard Truman, PI) was the successful bidder for part II. Part II is now responsible for producing and shipping to us about 6 kg per year of combined livers and spleens from infected armadillos with up to 1010AFB/g tissue resulting in a yield of about 10 g of pure M. leprae per year. This contract has been subsequently awarded in 2002. In addition, in August...
Words: 3042 - Pages: 13
...Non-Small-Cell Lung Cancer Lung cancer, the most preventable cancer, it is the leading cause of cancer-related deaths in men and women in Canada. In 2008, it was estimated that there would be 23,900 new cases (12,600 men and 11,300 women) of lung cancer in Canada and that there would be 20,200 deaths (11,000 men and 9200 women) from lung cancer in Canada (Lewis, Heitkemper McLean, Dirksen Ruff, O’Brien Graber, & Bucher). Non-small-cell lung cancer (NSCLC) is a term for different types of lung cancers that have different types of cancer cells that grow and spread in their own way. NSCLC accounts for 80-85% of all lung cancer cases and includes squamous cell carcinoma, adenocarcinoma, and large cell carcinoma (Gutierrez-Cabezon & et al. 2012), which are the most common types of non-small-cell lung cancer. There are some rare types of NSCLC but the purpose of this essay is to cover the most common types of non-small-cell lung cancer. Overview of Non-small-cell Lung Cancer Squamous cell (epidermoid) carcinoma is closely correlated to smoking and environmental carcinogens such as “asbestos, radon, nickel, iron and iron oxides, uranium, polycyclic aromatic hydrocarbons, chromates arsenic, and air pollution” (Lewis et al., 2010). The squamous cell carcinoma tends to originate in the central bronchi as an intraluminal growth and is thus more amendable to early detection through cytologic examination of sputum than other forms of lung cancer (Hannon, Pooler & Porth)...
Words: 3661 - Pages: 15
...physical harm, discomfort, pain, embarrassment, and the loss of privacy (Cooper & Schindler, 2011). According to “Copper & Schindler” (2011), “Many corporations, professional associations, and universities have a code of ethics.” Ethics are an important part for a business and researcher when conducting a research, but sometimes ethics are violated. Some of the ways a business or a researcher may violate the ethical standards are by violating an individual’s confidentiality, and changing data, or creating false data. Unethical research behavior does not only affects the business but can also have an effect the individual(s) participating in the research. Pfizer and Parke-Davis who are a pharmaceutical companies and Dr. Potti who studies cancer and works at Duke University are an example of how organizations can be part of an unethical behavior. Because of their unethical behavior not only their organization suffers but also the participants may be affected by it. The purpose of the pharmaceutical companies is to develop safe drugs and use them to treat ongoing diseases and new ones. With the use of these drugs many people will be able to treat their disease to have a healthier lifestyle. With the demand of new drugs to cure or treat new...
Words: 2006 - Pages: 9
...lymphoma (EATL) is a complication of celiac disease (CD). This tumor derives from the neoplastic transformation of aberrant intraepithelial T lymphocytes emerging in celiac patients unresponsive to a gluten-free diet. Poor adherence to a gluten-free diet, HLA-DQ2 homozygosity, and late diagnosis of CD are recognized as risk factors for malignant evolution of CD. Recurrence of diarrhea, unexplained weight loss, abdominal pain, fever, and night sweating should alert physicians to this complication. The suspicion of EATL should lead to an extensive diagnostic workup in which magnetic resonance enteroclysis, positron emission tomography scan, and histologic identification of lesions represent the best options. Treatment includes high-dose chemotherapy preceded by surgical resection and followed by autologous stem cell transplantation, although biologic therapies seem to be promising. Strict adherence to a gluten-free diet remains the only way to prevent EATL. (Blood. 2012;119(11): 2458-2468) Introduction Celiac disease (CD) is a chronic gluten-sensitive enteropathy characterized by a high prevalence in the general population and an increased mortality.1,2 It is well known that the increased mortality is mainly the result of the complications of CD itself, represented by refractory CD (RCD) and enteropathy-associated T-cell lymphoma (EATL).2 RCD is a form of CD that does not respond histologically to at least 12 months of a...
Words: 9183 - Pages: 37
...Drug Development for Melanoma As the director of the drug development unit in a biotech company we are always looking for new drugs to treat a variety of different cancers. There are many things that have to be considered when trying to get a drug to go from being an idea in a laboratory to something that can be used by cancer patients everywhere. The process of getting a drug development can be very lengthy. It could take many years and a lot of money before it could get approved to be used by doctors. In order for a drug to be developed it has to go through many testing periods. In order for a new drug to be taken by people, there must be an application submitted to the Investigational New Drug (IND) to the Food and Drug Administration....
Words: 3492 - Pages: 14
...Huang Qi Chinese Medical Herbology has always been the old companion of Traditional Chinese Medicine in the area of treatment. Their companionship has stretched back as far as four thousand years with archaeological evidence. Of the ten thousand herbs being documented, Huang Qi is to be thoroughly discussed in regards to its historical origins, botanical features, herbal properties, its use in Chinese medicinal treatment and contraindications and its modern use. Huang Qi is a fascinating herb that has stood the test of time. Chinese practitioners have never failed to utilise it in their clinics and practices. Origin and Botanical features Huang Qi 黃耆, roughly translated as "yellow leader", is also known by the pharmaceutical name Astragalus propinquus, It is one of the 50 predominantly used herbs that make up the fundamentals of Chinese Medicine. In some instances, it can also be known as Bei Qi. It was first recorded in Shen Nong’s Materia Medica about 2000 years ago and was then believed to stimulate immune function, invigorates Qi in the Chinese understanding (Braun, 2008). It is grown in the provinces of Jiangsu, Hubei, Maoshan, Henan, Inner Mongolia, Hebei, Shanxi, Liaoning and Heilongjiang, and predominantly acquired during spring and autumn where the hairy rootlets are removed and the actual plant itself is dried in the sunlight. Currently, microwave drying technology is employed because of easy extraction of effective components and constituents (Qianqian, Junhong...
Words: 1662 - Pages: 7