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Down Sydrome

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I have done my report on trisomy 21. This disease was later named Down Syndrome. In 1866 a doctor named John Langdon Down first saw some children that were similar to some other mentally retarded children. He had no idea what this disease was, but was the first person to study it. As time went on medicine became more advanced. In 1959 a French doctor named Jerome Legeune saw people who had this unknown disease, and that they had 47 chromosomes instead of 46 chromosomes. This disease was then given a name, trisomy 21. Trisomy means triplication, so the chromosomes triple on the 21st chromosome. Doctors also called this disease Down Syndrome because the first person who studied it was John Langdon Down. Down Syndrome is caused by a mess-up in cell splitting called non-disjunction. Non-disjunction happens 95 % of all Down Syndrome cases. Scientists still don’t know why non-disjunction occurs, but it seems to have different effects on ages of women. For example, women that are 35 years old have a one in 400 chance of giving birth to a baby with Down Syndrome. While if your 40, the chances go to one in 110, and if your 45 the odds climb to one in 35. Three to four percent of all the cases of Down Syndrome are from Robertsonian Translocation. This happens when there are two breaks in the 14th and 21st chromosome. Then the 14th chromosome is switched with the extra 21st chromosome. Some of these cases triple on part of the 21st chromosome instead of the whole. This is called partial trismony 21. One to two percent of all the cases of Down Syndrome are from mosaicism. These cases have a mixture of cell lines. Mosaicism is extremely rare. Since people with Down Syndrome have an extra chromosome, the extra genes lead to overexpression. Overexpression usually does not effect the body very much. Some of the ways that people with Down Syndrome

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