...Assignment topic: Liver Regeneration Submitted To : Dr.Samina By: Razia Saleem Quaid - e - Azam University Dept : Animal Sciences MSc 2nd Semester Index Page # 1. Introduction 3 2. Structure and functions of liver 3,4 3. Liver Regeneration 5 4. Two layers of defense against liver injury 5 5. Dynamics of liver regeneration 6 6. Stimuli of hepatic regeneration 7 7. Regeneration by hepatocytes (1st line of defense) 8 8. Signaling...
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...Advantage and Disadvantage of liver Transplantation After a liver transplantation, there are three types of graft rejection that may occur. They include hyper-acute rejection, acute rejection and chronic rejection. Hyper-acute rejection is caused by preformed anti-donor antibodies. It is characterized by the binding of these antibodies to antigens on vascular endothelial cells. Complement activation is involved and the effect is usually profound. Hyper-acute rejection happens within minutes to hours after the transplant procedure. Unlike hyper-acute rejection, which is B cell mediated, acute rejection is mediated by T cells. It involves direct cytotoxicity and cytokine mediated pathways. Acute rejection is the most common and the primary target of immunosuppressive agents. Acute rejection is usually seen within days or weeks of the transplant. Chronic rejection is the presence of any sign and symptom of rejection after 1 year. The cause of chronic rejection is still unknown but an acute rejection is a strong predictor of chronic rejections. Liver rejection may happen anytime after the transplant. Lab findings of a liver rejection include abnormal AST, ALT, GGT and liver function values such as prothrombin time, ammonia level, bilirubin level, albumin concentration, and blood glucose. Physical findings include encephalopathy, jaundice, bruising and bleeding tendency. Other nonspecific presentation are malaise, anorexia, muscle ache, low fever, slight increase in white blood...
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...Catering Marketing Plan Fressen Catering Page 1 2 3 4 5 Next Page > This sample marketing plan was created with Marketing Plan Pro software. Executive Summary Fressen Catering is a kosher catering company that serves the Philadelphia market. Fressen offers creative, colorful, and unusual food options for kosher, as well as the traditional kosher standbys. The service offerings are quite a change relative to the existing kosher catering market which is quite stagnant. Most people make the incorrect assumption that kosher means ordinary, boring food. This assumption prevails throughout the Jewish community so there is not much demand for new offerings. Fressen catering will inject new life into the kosher catering market, leveraging Chef Susan Cheflly's culinary skills to develop creative new catering options. Susan's advanced skills, industry insight, and a great market opportunity will allow Fressen Catering to reach profitability by month 11. Catering Marketing Plan Fressen Catering Page 1 2 3 4 5 < Previous Page | Next Page > This sample marketing plan was created with Marketing Plan Pro software. Situation Analysis Fressen Catering is a start-up company. Marketing is critical to its success and future profitability. Fressen offers creative, gourmet kosher catering for a wide range of events. The basic market need is a high quality, creative kosher catering company servicing the Philadelphia Jewish population...
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...THE DOCTRINE OF BAPTISMAL REGENERATION: AN ANALYSIS OF ITS ASSOCIATION WITH THE RESTORATION MOVEMENT A Research Paper Submitted to Liberty Baptist Theological Seminary Online In Partial Fulfillment of the Requirements for the Course Systematic Theology II (TH 530-D09) By Justin Hartpence (23828793) May 12, 2013 THESIS STATEMENT This paper shall argue that this is an inaccurate depiction and seek to put forth the common view of baptism in the Restoration Movement as distinct from the common understanding of baptismal regeneration, while pointing to key factors that play a role in popular inaccuracies. TABLE OF CONTENTS INTRODUCTION 1 DEFINING REGENERATION 2 DEFINING BAPTISM 3 The Mode 3 The Subject 4 The Meaning 6 According to Classic Baptismal Regenerationists 7 According to Restoration Movement Theology 8 BAPTSIM AS THE OCCASION OF SALVATION 9 John 3:5 9 Titus 3:5 11 BAPTISM'S RELATION TO FAITH 12 CONCLUSION 14 SELECTED BIBLIOGRAPHY 15 INTRODUCTION Change: it is an inevitable fact of life. Whether it is plant, animal, human or thought nothing exists for very long without addition or subtraction of some kind. Unfortunately theology is not immune. One need only survey the history of Christianity to see this disconcerting fact. Like a pendulum, however, as theology sways outward from its starting point there are inevitably forces that pull it back. This happened most notably in the Reformation under the guidance of reformers...
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...[pic] Term paper Stem cell therapy Irfan manzoor. Roll no: RP7002B22. Reg. no: 11000225. Course: Bsc. Biotech 1. Lovely professional university Contents 1. Stem cells and properties. 2-3 2. Stem cell therapy. 5-12 3. Stem cell use in animals 13-15 4. Recent researches in stem cell therapy 16-19 5. Conclusion 21 6. Bibliography 22 Stem cells Stem cells are cells found in all multi cellular organisms. They are characterized by the ability to renew themselves through mitotic cell division and differentiate into a diverse range of specialized cell types. Research in the stem cell field grew out of findings by Ernest A. McCulloch and James E. Till at the University of Toronto in the 1960s. The two broad types of mammalian stem cells are: embryonic stem cells that are isolated from the inner cell mass of blastocysts, and adult stem cells that are found in adult...
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...Jacob Thomas Mr. Defrank Environmental Science December 15, 2014 The Effect of Deer Overpopulation on the Environment White-tailed deer have increased dramatically in population during the last two decades due to the combination of several factors. With the increase in population of deer, many changes have occurred to the habitat of the deer which has caused changes to the habitat of other species, as well. These changes cause concern regarding the impact the overpopulation has on the environment and other species of animals. There is also an increased human health and safety issue with the increase of deer. Deer overpopulation is causing many concerns, including human health and safety concerns, ecological impacts, and economic losses. The human health and safety issues associated with deer are primarily deer-vehicle collisions and transmission of Lyme disease. “It is estimated that 29,000 people are injured and 211 lose their lives annually in deer-vehicle collisions in the United States.” (Curtis) This number continues to rise as the overpopulation of deer continues to increase. Deer are coming out of the woods for food and water which causes an increase in the number of deer in human populated areas and highways. Deer-vehicle collisions is also one of the many economic losses that is associated with the overpopulation of deer. The expense of vehicle repairs and, sometimes, medical bills, due to vehicle-deer collisions is very high. There is also the human...
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...Light-Induced Rod and Cone Cell Death and Regeneration in the Adult albino Zebrafish (Danio rerio) Retina Thomas S. Vihtelic and David R. Hyde Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556-0369 Received 24 January 2000; accepted 25 April 2000 ABSTRACT: Light-induced photoreceptor cell degeneration has been studied in several species, but not extensively in the teleost fish. Furthermore, the continual production of rods and cones throughout the teleost’s life may result in regeneration of lost rods and cones. We exposed adult albino zebrafish to 7 days of constant darkness, followed by 7 days of constant 8000 lux light, followed by 28 days of recovery in a 14-h light:10-h dark cycle. We characterized the resulting photoreceptor layer cell death and subsequent regeneration using immunohistochemistry and light microscopy. Within the first 24 h of constant light, the zebrafish retina exhibited widespread rod and cone cell apoptosis. High levels of cell proliferation within the inner nuclear layer (INL) were observed within the first 3 days of Light has been an effective and popular environmental method to experimentally induce photoreceptor cell degeneration. The light treatment can irreversibly cause photoreceptor cell loss through apoptosis (Shahinfar et al., 1991; Li et al., 1996). Factors such as light intensity and exposure duration, length of dark adaptation before light exposure, and ocular pigmentation influence the retinal damage in mice...
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...Plant succession is the process by which one plant community replaces another over time. Human activity can have an impact on the succession of plants in a number of ways these are known as arresting factors. A plagioclimax community is a habitat in which the impact of humans has subsequently meant that the ecosystem has been prevented from developing further. The plagioclimax with which I will give reference in this essay is heather moorland. It must be noted that much of the present vegetation in the UK is a plagioclimax as a result of clearance. Heather moorland provides a choice example of a plagioclimax in the UK. The areas where heather moorland is most prominent are the North York Moors, the Pennines and Eastern Scotland. Much of the land where Heather moorland now exists was once covered by deciduous woodland, the UK’s climatic climax, yet humans have had a critical impact on the way in which heather moorland has manifested itself in these areas. One must acknowledge that heather had featured in these areas prior to the suspension of succession. Humans removed deciduous woodland in these areas to make way for farmland as a result of the need to increase food production. By chopping down vast swathes of deciduous woodland, the soil in these areas began to deteriorate without the much needed nutrients associated with the deciduous woodland biome. Heather and other hardier plants such as Bracken, Grasses and Scrub Woodland began to dominate upland areas which had been impacted...
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...of all new genetic diversity, occurring when there are occasional errors in the replication of DNA or other elements of the production and packaging of genetic information within the cells. Although implies something negative, mutations can have positive, neutral, or deleterious impacts Mutations occur rather slowly but continuously. Mutations at one level, for example, in the nucleotides that are the basis of DNA, May not all is expressed at other levels — such as protein differences or observable changes in the appearance of a plant. The rate of mutation is useful in determining evolutionary relationships. Mutations can be beneficial, neutral, or harmful for the organism, but mutations do not "try" to supply what the organism "needs." Factors in the environment may influence the rate of mutation but are not generally thought to influence the direction of mutation. For example, exposure to harmful chemicals may increase the mutation rate, but will not cause more mutations that make the organism resistant to those chemicals. In this respect, mutations are random whether a...
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...With reference to one plagioclimax that you have studied, assess the impact of human activity on plant succession. (10 marks) Plant succession is the process by which one plant community replaces another over time. Human activity can have an impact on the succession of plants in a number of ways these are known as arresting factors. A plagioclimax community is a habitat in which the impact of humans has subsequently meant that the ecosystem has been prevented from developing further. The plagioclimax with which I will give reference in this essay is heather moorland. It must be noted that much of the present vegetation in the UK is a plagioclimax as a result of clearance. Heather moorland provides a choice example of a plagioclimax in the UK. The areas where heather moorland is most prominent are the North York Moors, the Pennines and Eastern Scotland. Much of the land where Heather moorland now exists was once covered by deciduous woodland, the UK’s climatic climax, yet humans have had a critical impact on the way in which heather moorland has manifested itself in these areas. One must acknowledge that heather had featured in these areas prior to the suspension of succession. Humans removed deciduous woodland in these areas to make way for farmland as a result of the need to increase food production. By chopping down vast swathes of deciduous woodland, the soil in these areas began to deteriorate without the much needed nutrients associated with the deciduous woodland biome...
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...2013).The benefits of Adult stem cell transplants (bone marrow transplants) have been used for over 40 years in successfully treating cancers such as leukemia, multiple myeloma and lymphomas, and research has now opened the doors to regenerative and reparative therapeutics. Adult stem cell treatment is widely used in the medical field and I will always support it. Amniotic stem cells “are multipotent stem cells of mesenchymal origin extracted from amniotic fluid. They are able to differentiate into various tissue type, such as skin, cartilage, cardiac tissue, nerves, muscle, and bone and have potential medical applications, especially in organ regeneration (MNT,2013) Induced pluripotent stem cells are adult cells that have been genetically reprogrammed to an embryonic stem cell–like state by being forced to express genes and factors important for maintaining the defining properties of embryonic stem cells (National Institute of health, 2013). The Benefit about using Human amniotic fluid cells (hAFCs) to help restore follicles in clinical condition involving premature ovarian failure. According to BMC Developmental Biology Human amniotic fluid stem cells have a potential to recover ovarian function in mice with...
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...The first question that arises when it comes to the story of forest fires is: What exactly is fire? This question can simply be answered that it is a chemical reaction involving fuel, oxygen and heat. The molecules of a combustible substance move around at an ever more rapid pace as the substance heats until it ultimately combusts totally. When this combustion takes place, the chemicals in whatever substance is being heated are broken down and combined with the oxygen present in the air, with the substance acting as the fuel. This combination causes two things to occur, heat and light, which is essentially fire. The intensity of fire is determined by the amount of fuel present, and as the heat increases, so does the rate of its spreading to other fuel sources. The next question to ponder is: What is the cause of forest fires? While the famous “Smokey the Bear” may tell us that only we can stop forest fires, the truth is that the overwhelming majority of forest fires are caused by lightning. There are other natural causes that can spark forest fires as well. Falling rocks can cause small sparks to be created, which in turn can light piles of dried out kindling such as twigs. Superheated lava from volcanoes can also engulf nearby forests, as can the superheated air caused by an eruption. However, as we all know humans can also cause forest fires. Sometimes these fires are started by accident, and sometimes on purpose. There is a myriad of different fuels that allow a forest...
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...CH02CH19-Yarmush ARI 12 May 2011 ANNUAL REVIEWS 15:43 Further Annu. Rev. Chem. Biomol. Eng. 2011.2:403-430. Downloaded from www.annualreviews.org Access provided by Imperial College London on 01/18/16. For personal use only. Click here for quick links to Annual Reviews content online, including: • Other articles in this volume • Top cited articles • Top downloaded articles • Our comprehensive search Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges Francois Berthiaume,1 Timothy J. Maguire,1 ¸ and Martin L. Yarmush1,2 1 Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854; email: ireis@sbi.org 2 Center for Engineering in Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114 Annu. Rev. Chem. Biomol. Eng. 2011. 2:403–30 Keywords First published online as a Review in Advance on March 17, 2011 artificial organs, skin, cartilage, liver, stem cells The Annual Review of Chemical and Biomolecular Engineering is online at chembioeng.annualreviews.org Abstract This article’s doi: 10.1146/annurev-chembioeng-061010-114257 Copyright c 2011 by Annual Reviews. All rights reserved 1947-5438/11/0715-0403$20.00 The past three decades have seen the emergence of an endeavor called tissue engineering and regenerative medicine in which scientists, engineers, and physicians apply tools from a variety of fields to construct biological ...
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...significant role in determining the overall success or failure of an implanted biomaterial. Rough titanium (Ti) surface microtopography and high surface free energy have been shown to enhance osteoblast maturation in vitro and increase bone formation in vivo. Whereas the surface properties of Ti are known to affect osteoblast response, host bone quality also plays a significant role in determining successful osseointegration. One factor affecting host bone quality is patient age. We examined both in vitro and in vivo whether response to Ti surface features was affected by animal age. Calvarial osteoblasts isolated from 1-, 3-, and 11-month-old rats all displayed a reduction in cell number and increases in alkaline phosphatase–specific activity and osteocalcin in response to increasing Ti surface microtopography and surface energy. Further, osteoblasts from the three ages examined displayed increased production of osteocalcin and local factors osteoprotegerin, vascular endothelial growth factor (VEGF)-A, and active transforming growth factor (TGF)-b1 in response to increasing Ti surface roughness and surface energy. Latent TGF-b1 only increased in cultures of osteoblasts from 1- and 3-month-old...
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...alteration of soil nutrients, change in pH of soil by plants growing there. The structure of the plants themselves can also alter the community. For example, when larger species like trees mature, they produce shade on to the developing forest floor that tends to exclude light-requiring species. Shade-tolerant species will invade the area. • Allogenic changes are caused by external environmental influences and not by the vegetation. For example soil changes due to erosion, leaching or the deposition of silt and clays can alter the nutrient content and water relationships in the ecosystems. Animals also play an important role in allogenic changes as they are pollinators, seed dispersers and herbivores. They can also increase nutrient content of the soil in certain areas, or shift soil about (as termites, ants, and moles do) creating patches in the habitat. This may create regeneration sites that favor certain species. 2 main types of Autogenic successions • Primary Succession: The process of creating life in an area where no life previously existed. • an...
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