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Facultative Chemotherapy

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Despite of enormous research efforts cancer still presents one of the leading causes of death worldwide. Although conventional chemotherapy helps to fight cancer but it shows some major drawbacks like, drug toxicity to normal cells, non selective drug distribution and limited toxicity to cancer cells, which results in toxic side effects to normal tissues and post treatment cancer recurrence.
An appropriate carrier for tumor specific drug delivery can limit the cytotoxicity of anticancer drugs against healthy cells. Bacteria can be engineered to overcome these limitations and to increase the efficiency of current chemotheraputics. Famous coley’s vaccine was developed on the basis of the fact that many bacterial strains show anticancer effect …show more content…
Unlike Obligate anaerobes (e.g. Clostridium and Bifidobacterium) which can grow selectively in solid hypoxic tumors, facultative anaerobes can target both aerobic and anaerobic tumor regions; these microbes show preferential growth in the immunocompromised tumor microenvironment due to the abundance of nutrients and protection from clearance by immune system. Previous studies show that Salmonella, a facultative anaerobe accumulates in tumors at ratios greater than 1000:1. However, potential risks associated with intravenous injection of pathogenic microbes discourage the use of these bacterial carriers in clinical practice. Intravenous injection of bacteria has been criticized as irrational because it may induce bacteremia and septicemia. So far, BCG is the only bacterial agent used for the treatment of superficial bladder cancer in clinical practice. It is considered as gold standard therapy for reducing recurrence and progression of bladder cancer. However, BCG immunotherapy is also associated with frequent induction of adverse side effects; hence some safer alternatives are required. Takeshi et al have shown that non pathogenic probiotic bacterium Bifidobacterium longum is safe and rational as a selective delivery tool to solid tumors, still being an obligate anaerobe Bifidobacterium cannot target aerobic regions of cancer tissues. However, non-pathogenic facultative anaerobes of genus Lactobacillus can overcome this

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