...cells, leading to the development of Rh antibodies. Rh incompatibility can occur by 2 main mechanisms. The most common type occurs when an Rh-negative pregnant mother is exposed to Rh-positive fetal red blood cells secondary to fetomaternal hemorrhage during the course of pregnancy from spontaneous or induced abortion, trauma,[1] invasive obstetric procedures, or normal delivery. Rh incompatibility can also occur when an Rh-negative female receives an Rh-positive blood transfusion. In part, this is the reason that blood banks prefer using blood type "O negative" or "type O, Rh negative," as the universal donor type in emergency situations when there is no time to type and crossmatch blood. The most common cause of Rh incompatibility is exposure from an Rh-negative mother by Rh-positive fetal blood during pregnancy or delivery. As a consequence, blood from the fetal circulation may leak into the maternal circulation, and, after a significant exposure, sensitization occurs leading to maternal antibody production against the foreign Rh antigen. Once produced, maternal Rh immunoglobulin G (IgG) antibodies may cross freely from the placenta to the fetal circulation, where they form antigen-antibody complexes with Rh-positive fetal erythrocytes and eventually are destroyed, resulting in a fetal alloimmune-induced hemolytic anemia.[2] Although the Rh blood group systems consist of several antigens (eg, D, C, c, E, e), the D antigen is the most immunogenic; therefore, it most commonly...
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...Purposes of Gene Cloning To study genes in the laboratory, it is necessary to have many copies on hand to use as samples for different experiments. Such experiments include Southern or Northern blots, in which genes labeled with radioactive or fluorescent chemicals are used as probes for detecting specific genes that may be present in complex mixtures of DNA. Cloned genes also make it easier to study the proteins they encode. Because the genetic code of bacteria is identical to that of eukaryotes, a cloned animal or plant gene that has been introduced into a bacterium can often direct the bacterium to produce its protein product, which can then be purified and used for biochemical experimentation. Cloned genes can also be used for DNA sequencing, which is the determination of the precise order of all the base pairs in the gene. All of these applications require many copies of the DNA molecule that is being studied. Gene cloning also enables scientists to manipulate and study genes in isolation from the organism they came from. This allows researchers to conduct many experiments that would be impossible without cloned genes. For research on humans, this is clearly a major advantage, as direct experimentation on humans has many technical, financial, and ethical limitations. Importance for Medicine and Industry The ability to clone a gene is not only valuable for conducting biological research. Many important pharmaceutical drugs and industrial enzymes are produced from cloned...
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...silent beasts that lurk in the body. Parkinson’s disease is a slow moving disease that slowly corrupts the brain. Parkinson’s disease (PD) is a chronic motor disorder that causes tremors, rigidity, slowed body movements, unstable posture and abnormal gait. This happens when neurons, nerve cells, in a part or the brain called the substantial nigra gradually die. These cells normally produce dopamine, a chemical that helps relay messages between areas of the brain that control body movement. The death of the cells leads to abnormal low levels of dopamine, and causes difficulty in controlling muscle tension and muscle movement both at rest and during periods of activity. PD as of now affects about 500,000 Americans, with about 50,000 new cases diagnosed each year. It is generally a disease that affects people of late or middle age at about age 60 however about 5 percent of patients have early-onset PD and are younger than 40 years old when symptoms begin. PD is slightly more common in men then women. So far scientists have not determined the reason why some people develop PD and others do not. Some experts blame a process called oxidation. During oxidation unstable molecules that areproduced in the brain as a result of its normal chemical reactions which ultimately damage the brain. Another theory suggests that the effects of toxic affects of drugs may cause PD. Additional evidence suggests that PD may be related to environmental toxins especially because some claim that they havefound...
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...INSTRUCTOR GUIDE Human Anatomy & Physiology Laboratory Manual MAIN VERSION, Eighth Edition Update CAT VERSION, Ninth Edition Update FETAL PIG VERSION, Ninth Edition Update ELAINE N. MARIEB, R.N., Ph.D Holyoke Community College SUSAN T. BAXLEY, M.A. Troy University, Montgomery Campus NANCY G. KINCAID, Ph.D Troy University, Montgomery Campus PhysioEx™ Exercises authored by Peter Z. Zao, North Idaho College Timothy Stabler, Indiana University Northwest Lori Smith, American River College Greta Peterson, Middlesex Community College Andrew Lokuta, University of Wisconsin—Madison San Francisco • Boston • New York Cape Town • Hong Kong • London • Madrid • Mexico City Montreal • Munich • Paris • Singapore • Sydney • Tokyo • Toronto Editor-in-Chief: Serina Beauparlant Project Editor: Sabrina Larson PhysioEx Project Editor: Erik Fortier Editorial Assistant: Nicole Graziano Managing Editor: Wendy Earl Production Editor: Leslie Austin Composition: Cecelia G. Morales Cover Design: Riezebos Holzbaur Design Group Senior Manufacturing Buyer: Stacey Weinberger Marketing Manager: Gordon Lee Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings, 1301 Sansome St., San Francisco, CA 94111. All rights reserved. Manufactured in the United States of America. This publication is protected by Copyright and permission should be obtained from the publisher prior to any prohibited reproduction, storage in a retrieval system, or transmission in any form or by any means...
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...Leptospirosis Leptospirosis is an infectious disease caused by bacteria belonging to the genus Leptospira. Leptospirosis occurs worldwide, but is most prevalent in tropical and subtropical regions. Outbreaks can occur following excessive rainfall or flooding. Etiology Virtually all wild and domestic mammals can harbour the bacteria that cause leptospirosis in their kidneys and genital tracts and act as source of infection to humans and other animals. • Rodents were the first recognized carriers of leptospirosis and are considered the primary source of infection to human beings. • Cattle, buffaloes, horses, sheep, goat, pigs and dogs are also considered common reservoirs of the bacteria that causes leptospirosis. Pathophysiology • Leptospirosis can be transmitted to humans through cuts and abrasions of the skin, or through the mucous membranes of the eyes, nose and mouth with water contaminated with the urine of infected animals. As animals are constantly in our environment, there is a particular danger of getting leptospirosis when flooding occurs, such as following a typhoon or very heavy seasonal rains, because of exposure to contaminated water when wading in floodwaters. • Leptospirosis can occasionally also be transmitted through the drinking of water or ingestion of food contaminated with urine of infected animals, often rats. • Human-to-human transmission occurs only very rarely. Risk Factors Outbreaks of leptospirosis have been reported following natural...
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...SPECIAL ARTICLE Postfertilization Effects of Oral Contraceptives and Their Relationship to Informed Consent Walter L. Larimore, MD; Joseph B. Stanford, MD, MSPH T he primary mechanism of oral contraceptives is to inhibit ovulation, but this mechanism is not always operative. When breakthrough ovulation occurs, then secondary mechanisms operate to prevent clinically recognized pregnancy. These secondary mechanisms may occur either before or after fertilization. Postfertilization effects would be problematic for some patients, who may desire information about this possibility. This article evaluates the available evidence for the postfertilization effects of oral contraceptives and concludes that good evidence exists to support the hypothesis that the effectiveness of oral contraceptives depends to some degree on postfertilization effects. However, there are insufficient data to quantitate the relative contribution of postfertilization effects. Despite the lack of quantitative data, the principles of informed consent suggest that patients who may object to any postfertilization loss should be made aware of this information so that they can give fully informed consent for the use of oral contraceptives. Arch Fam Med. 2000;9:126-133 Oral contraceptives (OCs) are among the most extensively studied and used medications in the world,1 and are accessible without a prescription in some countries, although still virtually unavailable in others. In America, OCs have...
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...How Many Fathers are Best? | Living World | DISCOVER Magazine Page 1 of 4 Print this page How Many Fathers are Best? 04.01.2003 After 40 years of visiting the Barí Indians in Venezuela, anthropologists have discovered a new twist on family values by Meredith F. Small, Photography by Abbas Anthropologist Stephen Beckerman was well into his forties before he finally understood how babies are made. He had thought, as most people do, that a sperm from one man and an egg from one woman joined to make a child. But one summer day, as he and his colleague Roberto Lizarralde lounged around in hammocks, chatting with Rachel, an elderly woman of the Barí tribe of Venezuela, she pointed out his error. Babies, she explained, can easily have more than one biological father. "My first husband was the father of my first child, my second child, and my third child," Rachel said, recalling her life. "But the fourth child, actually, he has two fathers." It was clear that Rachel didn't mean there was a stepfather hanging around or a friendly uncle who took the kid fishing every weekend. She was simply explaining the Barí version of conception to these ignorant anthropologists: A fetus is built up over time with repeated washes of sperm— which means, of course, that more than one man can contribute to the endeavor. This interview changed not only the way Beckerman and Lizarralde viewed Barí families but also brought into question the very way that anthropologists portray human Inez...
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...What is Cloning? Clones are organisms that are exact genetic copies. Every single bit of their DNA is identical. Clones can happen naturally—identical twins are just one of many examples. Or they can be made in the lab. Below, find out how natural identical twins are similar to and different from clones made through modern cloning technologies. How Is Cloning Done? Many people first heard of cloning when Dolly the Sheep showed up on the scene in 1997. Artificial cloning technologies have been around for much longer than Dolly, though. There are two ways to make an exact genetic copy of an organism in a lab: artificial embryo twinning and somatic cell nuclear transfer. 1. Artificial Embryo Twinning Artificial embryo twinning is a relatively low-tech way to make clones. As the name suggests, this technique mimics the natural process that creates identical twins. In nature, twins form very early in development when the embryo splits in two. Twinning happens in the first days after egg and sperm join, while the embryo is made of just a small number of unspecialized cells. Each half of the embryo continues dividing on its own, ultimately developing into separate, complete individuals. Since they developed from the same fertilized egg, the resulting individuals are genetically identical. Artificial embryo twinning uses the same approach, but it is carried out in a Petri dish instead of inside the mother. A very early embryo is separated into individual cells, which are allowed...
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...1 ) Rabies Rabies is a viral disease causing inflammation of the brain ( encephalitis ). The virus is a member of the family Rhaboviridae. Worldwide, several variants of the virus have been identified, each associated with a single wild animal host that acts as a reservoir of infection for a particular geographic area. Although all warm -blooded vertebrates are susceptible, only mammals are important in the spread of rabies. In British Columbia, bats are the only reservoir of rabies. Records of bats submitted for rabies testing suggest that relatively few are infected, even among those submitted because they are behaving abnormally. Bats are valuable components of the natural ecosystem and many species are at risk in British Columbia. Other potential hosts of British Columbia include domestic dogs/cats, foxes, raccoons, skunks, wolves and coyotes. " Spill over " of rabies to terrestial mammals from bats has occurred in British Columbia, but rabies has never been maintained in wild populations of terrestrial mammals. Rabies should be suspected in any wild animal exhibiting any behavior considered " abnormal" including ; loss of fear or unusual friendliness, excitation or aggression, depression, incoordination, paralysis, convulsions or seizures, abnormal vocalizations, appearance of nocturnal creatures during the day, signs of choking or inability to drink or swallow food, drooling of saliva or frothing at the mouth. In Carnivores, evidence of having...
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...—Carole Horn, The Washington Post Book World “This is a book that should be deeply disturbing to anyone who has given so much as a moment’s thought to the state of American medicine. But it is much more…People are presented as [Fadiman] saw them, in their humility and their frailty—and their nobility.” —Sherwin B. Nuland, The New Republic 3/462 “Anne Fadiman’s phenomenal first book, The Spirit Catches You and You Fall Down, brings to life the enduring power of parental love in an impoverished refugee family struggling to protect their seriously ill infant daughter and ancient spiritual traditions from the tyranny of welfare bureaucrats and intolerant medical technocrats.” —Al Santoli, The Washington Times “A unique anthropological study of American society.” —Louise Steinman, Los Angeles Times “Some writers…have done exceedingly well at taking in one or another human scene, then conveying it to others—James Agee, for instance…and George Orwell…It is in such company that Anne Fadiman’s writing belongs.” —Robert Coles, Commonweal...
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...that is not an inherent natural constituent of the food itself, in an amount that poses a reasonable possibility of injury to health, or (2) a substance that is an inherent natural constituent of the food itself; is not the result of environmental, agricultural, industrial, or other contamination; and is present in an amount that ordinarily renders the food injurious to health. The first includes, for example, a toxin produced by a fungus that has contaminated a food, or a pathogenic bacterium or virus, if the amount present in the food may be injurious to health. An example of the second is the tetrodotoxin that occurs naturally in some organs of some types of pufferfish and that ordinarily will make the fish injurious to health. In either case, foods adulterated with these agents are prohibited from being introduced, or offered for introduction, into interstate commerce. Our scientific understanding of pathogenic microorganisms and their toxins is continually advancing....
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...Name: C.T.B. Assignment: “Our Stolen Future” Date: 12/03/2012 The Book “Our Stolen Future” is considered to be a sequel of “Silent Spring“, a Rachel’s Carson classic work, a clarion call to protect the American public from manmade synthetic pesticides that cause genetic mutations and cancer. Carson not only described how persistent chemicals were contaminating the natural world, she documented how those chemicals where accumulated into our bodies. Since then, studies of human breast milk and body fat have confirmed the extent of our exposure. Human beings in such remote locations as Canada’s far northern Baffin Island now carry traces of persistent chemicals in their bodies, including notorious compounds as PCBs, DDT and dioxin. Even worse, in the womb and through breast milk, mothers pass this chemical legacy on to the next generation. “Our Stolen Future”, the scientific discovery of Theo Colborn, Dianne Dumanoski and John Peterson Myers, takes up where Carson left off and reviews a large and growing body of scientific evidence, linking synthetic chemicals to aberrant sexual development and behavioral and reproductive problems, such as low sperm counts, infertility, genital deformities, hormonally triggered human cancers, like those of breast and prostate gland, neurological disorders in children such as hyperactivity and deficits in attention. The quality of men's sperm declined steadily in the early years of the 21st century until hardly anyone could reproduce in...
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...IGOROTS * Home * IGOROT SONGS * IGOROT DANCE * IGOROT TRADITIONS * MONEY ON THE MOUNTAIN IGOROT TRADITIONS IGOROT TRADITIONS When we talk about Igorot identity and culture, we also have to consider the time. My point is that: what I am going to share in this article concerning the Igorot culture might not be the same practiced by the Igorots of today. It has made variations by the passing of time, which is also normally happening to many other cultures, but the main core of respect and reverence to ancestors and to those who had just passed is still there. The Igorot culture that I like to share is about our practices and beliefs during the "time of Death". Death is part of the cycle of life. Igorots practice this part of life cycle with a great meaning and importance. Before the advent of Christianity in the Igorotlandia, the Igorots or the people of the Cordilleran region in the Philippines were animist or pagans. Our reverence or the importance of giving honor to our ancestors is a part of our daily activities. We consider our ancestors still to be with us, only that they exist in another world or dimension. Whenever we have some special feasts (e.g., occasions during death, wedding, family gathering, etc.), when we undertake something special (like going somewhere to look for a job or during thanksgiving), we perform some special offer. We call this "Menpalti/ Menkanyaw", an act of butchering and offering animals. During these times we call them...
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...Study Guide Essentials of Psychology By Robert G. Turner Jr., Ph.D. About the Author Robert G. Turner Jr., Ph.D. has more than 20 years of teaching and education-related experience. He has taught seventh-grade science, worked as a curriculum developer for the Upward Bound Program, and taught sociology, social psychology, anthropology, and honors seminars at the university level. As a professional writer, he has written nonfiction books, journal and magazine articles, novels, and stage plays. Contents Contents INSTRUCTIONS TO STUDENTS LESSON ASSIGNMENTS LESSON 1: PSYCHOLOGY: THE SCIENCE OF THE MIND LESSON 2: THE MIND AT WORK LESSON 3: MOTIVATION, EMOTION, DEVELOPMENT, AND PERSONALITY RESEARCH PROJECT LESSON 4: PSYCHOLOGICAL DISORDERS LESSON 5: PSYCHOLOGY FOR TWO OR MORE CASE STUDIES SELF-CHECK ANSWERS 1 7 9 43 75 117 127 147 167 171 iii YOUR COURSE Instructions Instructions Welcome to your course, Essentials of Psychology. You’re entering a course of study designed to help you better understand yourself and others. For that reason, you can think of this course as practical. It should be of use to you in living your life and reaching the goals you set for yourself. You’ll use two main resources for your course work: this study guide and your textbook, Psychology and Your Life, by Robert S. Feldman. OBJECTIVES When you complete this course, you’ll be able to ■ Describe the science and methodologies of psychology in the context of its...
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...Chapter 1: Ethical Theory Meta-ethical positions include: * Ethical non-cognitivism (concept that ethics is a matter of feelings) * Ethical relativism (concept that ethics is relative to a particular point of view) * Ethical objectivism (notion that ethics is objective in nature). Meta-Ethical Positions Ethical Non-cognitivism The basis of ethical non-cognitivism is that ethical disagreement can be a highly emotional affair where no amount of reasoning is likely to convince the other party. * Example: “Let’s just agree to disagree” Ethical Relativism * Ethical relativism says that while ethical statements are cognitively meaningful, they do not hold in any objective sense because they depend on our point of view. * If we accept ethical relativism, then ethical disagreement among people who do not share the same perspective becomes impossible. * It assumes that if people agree on something, then it must be true. * Ethical relativism is suspect for a pragmatic reason: it is fundamentally at variance with our social practice. * Example: “To each his own”, or the belief that what’s right for one group isn’t necessarily right for another Ethical Objectivism * Ethical objectivism holds that right and wrong are objective phenomena. * Example: “I’m right and you’re wrong” What is Ethics? * As a discipline, ethics is a branch of philosophy. * It deals with questions of right and wrong conduct, and with what we ought to do and what...
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