As the play progresses the reader soon starts to see that Macbeth and Lad Macbeth’s relation ship is starting to deteriorate.
At this point in the play we are told that Macbeth is meeting up with two assassins.
He is asking them to do a terrible deed.

this I made good to you
In our last conference, pass'd in probation with you
How you were borne in hand, how cross'd, the instruments,
Who wrought with them, and all things else that might
To half a soul and to a notion craz'd
Say, 'Thus did Banquo.'"

This highlights that he has asked two murderers to kill his friend Banquo without telling his wife.

As the play continues we are told that there is a banquet and Lady Macbeth almost finds out about Macbeths secret of the murderers.
At this point in the play we are told that Macbeth is in his castle with different Lords and Noble men,
Macbeth tells his wife.
Be innocent of the knowledge, dearest chuck. Till thou applaud the deed

This emphasises that Macbeth wants to keep the secret until he knows that the deed has been done. This shows that their important relationship is dramatically changed for the worse and we see that the relationship is still spiralling downwards.

Later on in the play we are told that Macbeth has decided to kill Macduff’s family for fleeing to England which he has done without telling his wife Macbeth which shows us that the relationship between them has deteriorated quickly.

At this point Macbeth has just been told by the witches that he has to beware Macduff’s so Macbeth says

The castle of Macduff I will surprise; Seize upon Fife; give to the edge o' the sword His wife, his babes, and all unfortunate souls

This explains that he is going to kill Macduff’s family for his ‘treachery’ to his country.

Near the end of the play we are told that Lady Macbeth dies we are not told how she dies but her life ends at that moment

At this point in the play Macbeth is just about to face off with Macduff and his army when Seyton tells him and Macbeth replies with
The queen, my lord, is dead.

This extract from Seyton tells us that Lady Macbeth has died and Macbeth does not grieve her
There would have been a time for such a word.
To-morrow, and to-morrow, and to-morrow Shakespeare’s Macbeth is obviously a play in which there is a important relationship which changes
From the start of the play when Macbeth and Lady Macbeth’s relationship is as strong as could be to the end when there relationship is in rack and ruin