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Hepatitis C

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Submitted By amarina1
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History & description The disease that I will be bringing to the forefront is Hepatitis C. It is an infection of the liver, which has many forms, type 1 being the most common in the U.S. I will start by introducing the history of the disease and give a description of the disease and it’s affects to the body.1. “The hepatitis C virus is an RNA virus that belongs to the family flaviviridae.”1. “HCV replicates in the cytoplasm of hepatocytes””1. Persistent infection appears to rely on rapid production of virus and continuous cell-to-cell spread, along with a lack of vigorous T-cell immune response to HCV antigens”

Anatomy To better give a clear understanding of the failing organs I will address the body systems. I will further explain the anatomy of the systems that are involved.

Transmission & Cause 1.“The transmission of HCV is primarily through exposure to infected blood. Risks for transmission include blood transfusion before 1992, intravenous drug use, high-risk sexual activity, solid organ transplantation from an infected donor”2.” the fact that the genetic information of the virus is stored in RNA, not DNA, has important consequences in the life cycle of the virus, and gives hepatitis C its dangerous ability to mutate.”2.” Hepatitis C, as an RNA virus, has a powerful reproductive strategy. Because it stores its information in a "sense" strand of RNA, the viral RNA itself can be directly read by the host cell's ribosomes, functioning like the normal mRNA present in the cell.”2. Hepatitis C is not spread through casual contact, food or water. The virus spreads through blood or body fluids. 3.” You can catch it from:
•Sharing drugs and needles
•Having sex, especially if you have an STD, an HIV infection, several partners, or have rough sex
•Being stuck by infected needles
•Birth -- a mother can pass it to a child”

Signs & symptoms This infection carry very few symptoms, therefore most people do not know they have Hepatitis C. 3.” •Jaundice (a condition that causes yellow eyes and skin, as well as dark urine dark urine)
•Stomach pain
•Loss of appetite
•Nausea
•Fatigue
Diagnosis
The disease/infection is simply diagnosed through a blood test. 4.” Tests to detect antibody to hepatitis C virus (anti-HCV) were first licensed by the Food and Drug Administration (FDA) in 1990. “In certain clinical settings, false-positive anti-HCV results are rare because the majority of persons being tested have evidence of liver disease and the sensitivity and specificity of the screening assays are high 4.” However, among populations with a low (<10%) prevalence of HCV infection, false-positive results do occur.”
Treatment & side effects In recent years the treatment for Hepatitis has changed.3.” The latest is a once-daily pill called Harvoni that cures the disease in most people in 8-12 weeks.” The known listed side effects have been fatigue and headache. The medication is very expensive for the average American today. There are other medications that are cheaper that a doctor could recommend in either a tablet, capsule or liquid. 3.”Interferon and ribavirin used to be the main treatments for hepatitis C. They can have side effects like fatigue, flu-like symptoms, anemia, skin rash, mild anxiety, depression,nausea, and diarrhea.” The most common effects of hep C drugs are:
•Flu-like symptoms
•Fatigue
•Hair loss
•Low blood counts
•Trouble thinking
•Nervousness
•Depression”3.
Prevention
There are no exact preventions for hepatitis C. Some known prevention methods include,
•Use a latex condom every time you have sex .
•Don't share personal items like razors.
•Be careful if you get a tattoo, body piercing or manicure . The equipment may have someone else's blood on it.
•Don't donate blood or tissue if you’re infected.

References

Chen, S., & Morgan, T. (n.d.). The Natural History of Hepatitis C Virus (HCV) Infection. Retrieved November 16, 2015, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1415841/

Anatomy of the Hepatitis C Virus. (n.d.). Retrieved November 16, 2015, from http://www.epidemic.org/thefacts/hepatitisc/anatomy/

Hepatitis C Facts, Symptoms, Causes, Treatments. (n.d.). Retrieved November 16, 2015, from http://www.webmd.com/hepatitis/hepc-guide/digestive-diseases-hepatitis-c

Hepatitis C Facts, Symptoms, Causes, Treatments. (n.d.). Retrieved November 16, 2015, from http://www.webmd.com/hepatitis/hepc-guide/digestive-diseases-hepatitis-c

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