...be familial and heritable, in previous studies. As with most psychiatric disorders, examination of pedigrees has not revealed a consistent Mendelian mode of transmission. The response of ADHD patients to medications that inhibit the dopamine transporter, including methylphenidate, amphetamine, pemoline, and bupropion, led us to consider the dopamine transporter as a primary candidate gene for ADHD. To avoid effects of population stratification and to avoid the problem of classification of relatives with other psychiatric disorders as affected or unaffected, we used the haplotype-based haplotype relative risk (HHRR) method to test for association between a VNTR polymorphism at the dopamine transporter locus (DAT1) and DSM-IR-diagnosed ADHD (N = 49) and undifferentiated attention-deficit disorder (UADD) (N = 8) in trios composed of father, mother, and affected offspring. HHRR analysis revealed significant association between ADHD/UADD and the 480-bp DAT1 allele (X2 7.51, 1 df, P = .006). When cases of UADD were dropped from the analysis, similar results were found (X2 7.29, 1 df, P = .007). If these findings are replicated, molecular analysis of the dopamine transporter gene may identify mutations that increase susceptibility to ADHD/UADD. Biochemical analysis of such mutations may lead to development of...
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...Difference between QA and QC As we've talked in a previous post about the Definition of Quality, with these 2 terms exist the same “issue” where every single person/organization defines Quality Assurance (QA) and Quality Control (QC) in a bit different way. Also, many people including HHRR (Human Resources) and quality professionals do not know what QA and QC really means, and what the difference is between both terms. For those reasons, these concepts are often used interchangeably, and in some organizations one department performs the activities of both. The truth is that both terms have strong interdependence; QA relies mostly on the QC feedback and both work to deliver good quality products/services; but they are different processes. Next table shows the differences between them. QA vs. QC Definition from ASQ.org Assurance: The act of giving confidence, the state of being certain or the act of making certain. QA: The planned and systematic activities implemented in a quality system so that quality requirements for a product or service will be fulfilled. Other definition QA is a failure prevention system that predicts almost everything about product safety, quality standards and legality that could possibly go wrong, and then takes steps to control and prevent flawed products or services from reaching the advanced stages of the supply chain. Definition from ASQ.org Control: An evaluation to indicate needed corrective responses; the act of guiding...
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