...Toxicology Student’s Name Affiliation Date 1. Snakebites are often treated by administering specific “anti-venom”. Explain how “anti-venom” may work. Snakes are cold blooded animals that are found in tropical and subtropical countries. Snakes have some glands in their mouth that produce very poisonous substance and its even worst through their bites. The seriousness or extend of the poison depends on various factors. One is the body tissue where the venom is injected. It’s more serious when the poison is injected directly to the blood vessels meaning it spreads very quickly through blood transmission in the rest of the body. The extent of the poison also depends on the part of the body where the snake bites. Snake bites that occur on parts of the body with a lot of adipose tissue are less poisonous than in the parts with less adipose tissue. This is because these tissues are low in blood supply hence they end up delaying transmission or the spread of poison to the rest of the body (Timbrell, 2009) Specific anti-venom is used in treating snake bite since the severity of the poison depends on the snake type and other factors. Since the venom is injected in the blood the anti-venom should also be administered to the blood In order to neutralize the poison. This means that it might have some side effects if not well used since its injected directly to the blood. The anti-venom neutralizes the poisonous venom injected...
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...Environmental Toxicology Paper ENV/410 Environmental Toxicology Paper I will first explain the difference between toxicokinetics and toxicodynamics. Toxicants interact with living organisms in a series of five time-dependent processes. The study of these processes is called toxicokinetics. These processes are absorption, distribution storage, biotransformation and elimination. There are unique cellular effects within the organism when they come in contact with the toxicant. Toxicodynamics is an examination of the way these effects happen. There are many similarities as well as important differences between the toxicokinetics and pharmacokinetics of most substances. The same applies to pharmacodynamics and toxicodynamics (Olson, n.d.). The approach for conducting toxicokinetics studies that is recommended by most scholars generally involves three steps. Goehl (1997), "Step 1 is a preliminary study, which uses a minimum number of animals to estimate the range of blood/tissue concentrations, the required quantitation limit for the analytical method, and the optimal sampling times for the definitive toxicokinetic studies. Step 2 is the definitive study and generates blood and/or tissue concentration data for calculating the toxicokinetic parameters. Step 3 is the toxicokinetic study conducted in conjunction with the toxicology study to determine the internal dose and the effects of age and continuous exposure on kinetic parameters” (Toxicokinetics in the National Toxicology Program)...
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...Environmental Toxicology Paper Joshua Brechtel ENV/410 September 14, 2014 Jennifer Ott Environmental Toxicology Paper Environmental toxicology deals with the toxicology of environmental chemicals. This can relate to toxic chemicals found naturally but usually man-made chemicals are predominately studied. The effect of these chemicals on the environment and subsequent ecosystems are of great importance in understanding human impact on our planet. Ecotoxicology is a type of environmental toxicology that deals with the effects of environmental toxins on ecosystems, habitats and the organisms that live in those ecosystems. The wide range of organisms and environmental factors requires detailed analysis from multiple scientific disciplines. Toxicokinetics and Toxicodynamics Toxicokinetics is a branch of toxicology that can be viewed as the study of how the body deals with toxicants at different stages after exposure. These stages are absorption, distribution, and elimination. Toxicokinetics studies the ever changing processes that occur within the body during and after absorption of a toxicant. This includes where and how absorption takes place, how the body distributes the toxicant, the effects of metabolism, the toxic effects rendered and the excretion of the toxicant. “In other words, toxicokinetics is a reflection of how the body handles toxicants as indicated by the plasma concentration of that xenobiotic at various time points.” (Michael A. Trush, 2008, p...
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...abnormal process in cells which leads to cancer. • Developmental toxicity. This group refers to toxic responses to the developing embryo. This occurs due to the exposure of toxic substances to your partners prior to the act of conception. This leads to the death of cells of the fetus. • Genetic toxicity. The major cause of this kind of toxicity is a severe damage of DNA. This process is known as mutagenesis. It leads to cancer, or death of the cell. • Organ toxicity. This group is associated to toxic responses to different organs. It involves blood and cardiovascular toxicity, eye toxicity, dermal toxicity, reproductive toxicity, respiratory toxicity and various forms. (Hodgson, 2004, p.275) References Hodgson, E. (2004) A Textbook of Modern Toxicology. Wiley-Interscience; 3-rd edition. Question 2 List and provide a brief explanation of the types of Phase I reactions of metabolism of foreign substances. The types of Phase 1 reactions are: Oxidation- This is the additional of oxygen or removal of hydrogen to a substrate will make the compound more...
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...Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms, mechanisms, detection and treatments of toxic substances, in particular relation to the poisoning of humans. It is difficult to discuss toxic phenomena at different levels of biological organisation separately because of complex relationship and interlinking between such levels. It should be noted that every biological level toxicology includes chemical and/or molecular toxicology in a sense. Scientists need to study natural situations to understand life processes and to investigate how introducing a particular substance can change living systems. It is often helpful to break a process into steps and then investigate how introduction of the substance affects each step. This first stage in toxicity assessment takes place in vitro. The investigator can pinpoint the various changes that could occur when a compound encounters a living cell and then make safety recommendations. Only a few substances successfully pass these initial trials. Those substances must then be tested further. Humans and other living things—plants, animals, and even molds and bacteria—are complex systems. The processes in any organism are far more complicated than just the sum of the individual parts. It is difficult to replicate at the lab bench the complex interactions. When safety is not assured, ethical research procedures restrict testing on...
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...Toxicology and Industrial Health http://tih.sagepub.com Mercury vapor inhalation and its effect on glutathione peroxidase in goldsmiths exposed occupationally K. Jayaprakash Toxicol Ind Health 2009; 25; 463 originally published online Jul 31, 2009; DOI: 10.1177/0748233709106769 The online version of this article can be found at: http://tih.sagepub.com/cgi/content/abstract/25/7/463 Published by: http://www.sagepublications.com Additional services and information for Toxicology and Industrial Health can be found at: Email Alerts: http://tih.sagepub.com/cgi/alerts Subscriptions: http://tih.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.co.uk/journalsPermissions.nav Citations http://tih.sagepub.com/cgi/content/refs/25/7/463 Downloaded from http://tih.sagepub.com at SAGE Publications on November 9, 2009 Mercury vapor inhalation and its effect on glutathione peroxidase in goldsmiths exposed occupationally K Jayaprakash Toxicology and Industrial Health 25(7) 463–465 ª The Author(s) 2009 Reprints and permission: http://www. sagepub.co.uk/journalsPermission.nav DOI: 10.1177/0748233709106769 tih.sagepub.com Abstract In the gold ornaments manufacturing cottage industries, the gold metal grain dust waste particles are recovered from mercury (Hg) amalgam. The results on air samples from these industries during the recovery process have shown a high prevalence of Hg vapor (42.7 mg/m3). The blood concentration...
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...Risk Assessment Hazard Identification Risk assessment begins with hazard identification. Malathion is a wide spectrum, non-systemic organophosphate insecticide commonly used to control ectoparasites, household insects, sucking and chewing insects in agriculture, and mosquito populations (Pmep.cce.cornell.edu 2012). It is also sold over the counter as a medicine used to kill lice and their eggs. Toxicity in animals depends on product purity and the method it is administered. Dose-Response Assessment Dose responses in humans and animals differ from species to species and according to dose concentration. Malathion exposure occurs through ingestion, inhalation, and absorption. Human exposure usually results in nausea, headache, and tightness in the chest. Although Malathion is classified as a slightly toxic, lethal doses have been recorded for humans. The lowest lethal dose of Malathion recorded is three times higher for men than women (Pmep.cce.cornell.edu 2012). Alergic reaction to Malathion causes severe dizziness and trouble breathing. Lab tests indicate that rats do not normally have adverse reproductive and development effects from Malathion exposure at low doses and prolonged exposure. High doses can cause teratogenic effects when fed to rats through a stomach tube. Malathion can, however, pass through the placenta of pregnant goats and cause birth defects and increased newborn mortality rates. Chronic toxicity may cause mutagenic risks to humans. Lab test results...
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...THE RESEARCH QUESTION The study should be based on finding out the effects of toxins on living organism. This research will try to find out the positive and negative effects of enzyme toxin in plants and animals. The excessive use of toxins can be harmful to the environment while the use of controlled amounts of this same enzyme can be useful to the environment. Toxins are said to be any poisonous substances that are produced in the living cells. Organic chemist Ludwig Brieger is said to be the first chemist to use the word toxins in the 19th century. Small molecules, proteins and peptides are all said to be toxins. These organisms are capable of causing diseases on the contact with any contact or absorption by body issues. Toxins greatly vary in the degree of severity from the minors such as bee stings to majors such as botulinum toxins Toxins are also constituents that are made by plants and are harmful to humans. But some toxins can be used in small doses and help in medication but become poisonous when used in large amounts DESCRIPTION OF IDENTIFIED PERSPECTIVE (natural sciences) In the natural science subjects such as biology and chemistry, toxins are well described and experimented on by scientists. In chemistry toxins are said to be chemical agent depending on their method of production. On the other hand, toxins that disturb organisms may be said to be biologically produced. Toxins can be either biologically or chemically produced depending on the mode of production...
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...Mung Beans A mung beans experiment for the subject I toxicology. Find a toxicant to be applied on the plant. We have 5 days to observe. It’s not just dead or alive. Mung Beans A mung beans experiment for the subject I toxicology. Find a toxicant to be applied on the plant. We have 5 days to observe. It’s not just dead or alive. Mung Beans A mung beans experiment for the subject I toxicology. Find a toxicant to be applied on the plant. We have 5 days to observe. It’s not just dead or alive. Mung Beans A mung beans experiment for the subject I toxicology. Find a toxicant to be applied on the plant. We have 5 days to observe. It’s not just dead or alive. Mung Beans A mung beans experiment for the subject I toxicology. Find a toxicant to be applied on the plant. We have 5 days to observe. It’s not just dead or alive. Mung Beans A mung beans experiment for the subject I toxicology. Find a toxicant to be applied on the plant. We have 5 days to observe. It’s not just dead or alive. Mung Beans A mung beans experiment for the subject I toxicology. Find a toxicant to be applied on the plant. We have 5 days to observe. It’s not just dead or alive. Mung Beans A mung beans experiment for the subject I toxicology. Find a toxicant to be applied on the plant. We have 5 days to observe. It’s not just dead or alive. Mung Beans A mung beans experiment for the subject I toxicology. Find a toxicant to be applied on the plant. We have 5 days to observe. It’s not just dead or alive....
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...Small amounts of chemical exposure (especially at vulnerable developmental stages) can have long term health impacts. Chemicals, such as heavy metals, Dioxin, and Bisphenol A; have been linked to cancer, developmental disabilities, Alzheimer’s disease and more (Peeples 2012). . Ninety-nine percent of pregnant American women carry multiple man-made chemicals in their bodies, sharing them through the umbilical cord (Peeples 2012). Disease causing agents are toxic chemicals that persist in the environment and accumulate within food chains. They transfer easily among air, water, and land, and span boundaries of programs, geography, and generations (epa.gov, 2012). Common toxicants include antimicrobials and biocides, and heavy metals like mercury, lead, antimony, arsenic and cadmium. Antimicrobial and biocides are used in plastics and textiles to kill microorganisms. These are aquatic toxins; some cause bacteria and fungi to mutate. Utilization of these compounds can expedite the evolutionary process leading to superbugs. The long-term effects of antimicrobials and biocides are unknown. Heavy metals are usually associated with wire insulation, solder, dyes and pigments. Toxins released in the environment by these processes are; bio-accumulative; broad range of negative health impacts including carcinogenicity (saferchemicals.org 2012). During the last two decades, chronic disease has replaced infectious disease as the major focus of public health concern, even with the appearance...
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...Blood agents are poisons that act on the body by being consumed into the blood (http://emergency.cdc.gov/agent/blood/). There are three known blood agents as identified by the Center for Disease Control: Arsine (SA), Carbon Monoxide (CO), Cyanide, and Sodium monofluoroacetate (compound 1080). I will attempt to discuss in detail how each blood agent enters the body and effects the human body. Blood agents extract from its effect on exposed victims. Blood agents generally enters the body by way of inhalation. It paralyzes the ability of the blood cells to harness and transfer oxygen to the blood. Because the blood agent prevents the transfer of oxygen to the blood, it causes the body to suffocate within. Arsine By definition, arsine is has no color, flammable, non-irritating lethal gas with a benign garlic odor. It is generated when arsenic comes in unity with an acid (http://emergency.cdc.gov/agent/arsine/facts.asp). It has been reported that a half-hour exposure to 25-50 ppm can be lethal (Blackwell and Robins, 1979). Clinical signs of arsine present in the body are: abdominal pain, blood in urine, and jaundice. Symptoms that follow showing signs of acute exposure are: headaches, weakness, inability to release bowel, which usually causes vomiting and nausea due to stress on the body. Arsine was investigated as a warfare agent during World War II, but was never used on the battlefield (http://emergency.cdc.gov/agent/arsine/facts.asp). Certain industrial processes...
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...Application Assignment #3 – Equilibrium and Electrochemistry According to Chemicool chelation is the “formation or presence of bonds between two or more separate binding sites within the same ligand and a single central atom” (chemicool). Chelation therapy is a process in which reduction of toxic effects of metals within the human body take place. The agents often bind to the toxic ions and form structures that are then easily excreted. Most agents are made up of atoms like Sulphur, Nitrogen and Oxygen functioning as ligand atoms. As metals release toxic substances into the human body the need for an agent to try and reduce the toxicity for our well being is necessary. Most of the heavy are toxic such as lead, copper and zinc which accumulate in the human body. The process of chelation causes a chemical reaction involving a shift of equilibrium to remove the metals before the organs get permanently damaged. The shift in equilibrium occurs because when the agent is introduced to the body to try and reduce the effects, with the body being the system it tries to re-establish equilibrium by shifting from left to right. Barium sulphate is usually made by a combination of a solution of the ions and salts of barium and sulphate. Barium being a heavy metal is highly toxic. In colour it is a white solid with a crystal structure. The reason that Barium sulphate salt is used is that the ions of Barium are opaque to x-rays and can absorb the rays much better than other compounds. Without...
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...Childhood lead poisoning is one of the most common pediatric problems currently in the United States, despite the fact that it’s very preventable. Lead poisoning is a danger because in most cases, it is without symptoms; therefore, it can go undiagnosed and even untreated. In statements published by the CDC in 1985, the threshold for blood lead level was 25 µg/dL, however it was noted that adverse effects occur at levels as low as 10 µg/dL [3]. Since health effects have been noted in levels even lower than 10 µg/dL, there is no set threshold as to what level of lead poisoning can be considered a danger. Therefore, primary prevention utilizes the involvement of pediatric health-care providers, public housing agencies, and public organizations by reducing lead exposure from residential lead hazards, industrial sources, contaminated foods or water, and other consumer products. The harmful effects of lead were detected as early as the 1890’s, and by the 1920’s several European countries had begun to take measures in prohibiting the use of lead-based paint. It wasn’t until 1971 that the U.S. issued the Lead-Based Poisoning Prevention Act, which banned the use of lead-based paint in government funded housing. This act led to a series of precautionary measures to decrease the amount of lead exposure. In 1973, EPA announced a discontinuation of the use of lead in gasoline; restrictions were placed on lead in residential paint in 1978; in 1974 the Safe Drinking Water Act was passed;...
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...Module 7, Course 2, Session 18 Growth Strategies - External March 9, 2013 Discussion Topics Section Introductions and Segment Objectives The Acquisition Process – Target Research and Process Execution Case Studies Concluding Thoughts – Keys to Success Background Information on John Dickinson Page 2 3 7 15 17 CONFIDENTIAL 1 Introductions and Segment Objectives Introductions: • • John Dickinson – Session Leader Participants – Goals, objectives, questions, and backgrounds CONFIDENTIAL Session Objectives: • Why pursue external strategies? • • • Limited organic growth versus strategic goals New products / services, end markets, technologies, and customers, as well as sourcing synergies What are some of the strategies? • • • Joint ventures – private and public / governmental Acquisitions Divestitures and re-investing in the core business The Acquisition Process: • • Strategic goals and target identification / research Deal execution – the team, valuation / structure, and culture / integration 2 CONFIDENTIAL The Acquisition Process – Target Research and Deal Execution 3 Developing the Optimal Acquisition Process CONFIDENTIAL Optimizing the process begins with analyzing the unique dynamics of the Buyer’s situation, and then developing an appropriate and flexible strategy for achieving the Buyer’s goals. Process Considerations Current End Market Dynamics & Outlook Parent Company Objectives & Resource Commitment Management Team Objectives...
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...Toxicity Paper ENV/410 Toxicity Paper Chemicals that produce systemic toxicity do not always produce the same degree of toxicity in all organs. Instead, one or two organs are usually the target of most of the toxicity produced by the toxic chemical in question. These are the target organs for the toxicity for that chemical. The organ that is the target of toxicity most commonly involved in systemic effects is the central nervous system followed by skin, blood circulation system, liver, lungs and kidneys. Muscle and bones as well as the male and female reproductive systems often suffer debilitating impacts from many substances. Target organs can also refer to an organ is targeted to receive a therapeutic dose of irradiation. An example would be beaming gamma rays to the renal area of a kidney for the treatment of a tumor. Another example of a target organ is the thyroid gland, when the anterior pituitary gland secretes a thyroid stimulating hormone (Silbergeld, 2011). Target organ toxicity is when a toxins adverse effects or disease states manifest in specific organs in the body. The higher the cardiac output, the higher the exposure. Organs each have specialized tissues and cells with differentiated cellular processes and receptors while some toxicants and metabolites may have specific reactive pathways. As pointed out previously, toxicants do not always affect all organs to the same extent. There could be several sites of action and target organs for a particular...
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