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Of Mice Observation Paper

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The researchers included Figure 2 in the paper for the purpose of accentuating to the reader that when MFB stimulation is paired with place cell activity, it does in deed create a goal oriented behavior, as the researchers predicated. With a quick glance, the figure visually demonstrates that the spatial behavior of the mice show a clear preference for the area that has been associated with the MFB stimulation.
Figure 2 accomplishes this by starting off with a diagram of occupancy maps that allow the reader to see the place preferences of the mice during both a PRE and POST session. The PRE session takes place prior to MFB stimulation and the POST session takes place directly after the stimulation. During the PRE session, the researchers allowed the mice to freely explore their given environment and while doing so, the researchers were able to identify specific place cells with their correlating neuronal activity, which allowed them to identify precisely which place cells fire in a given place field. Once this information was obtained, the researchers were then able to stimulate the MFB while particular place cells were firing. This pairing of the stimulation with the place cells …show more content…
The difference between these two categories is the stimulation session. The experiment in figure 2a included stimulation that took place while the mice were awake and the experiment in figure 2c included stimulation that took place while the mice were asleep. During the wakeful stimulation in 2a, the mice received MFB stimulation when a place cell was activated by their location in their environment; a location which correlated the place cell with the place field. This MFB stimulation created an association for the mice between that particular area that was associated with the stimulation and a false reward memory, causing the mice to spend significantly more time in that

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