Sepsis leads to ARDS – Sepsis is the leading cause of ARDS because bacterial cells can activate inflammatory mediators leading to bronchoconstriction, increased alveolar capillary permeability, and vascular narrowing and obstruction. This causes a migration of blood cells and fluids from capillaries leading to pulmonary edema and impaired gas exchange all leading to ARDS. (Lewis med surg 1757) good
Sepsis and DIC – protein c levels are decreased in sepsis and DIC. Protein c is anticoag meaning a deficiency could lead to increased bleeding good expand

Sepsis to CVA – body’s response to microorganism is exaggerated, increased inflamm and coag and decrease in fibrinolysis. Toxins from microorganism cell wall release cytokines (tnf, il1, il6) and PAF. PA F  microthrombi formation and obstruction of microvasculature. Good - set up house in brain. …show more content…
Pulmonary HTN leads decreased CO. Less o2 and blood flow to the brain leads to CVA good
ARDS to DIC – direct lung injury leads to damage of capillary endothelium in lungs stimulates platelet aggregation, activates clotting cascades and could lead to overstimulation of production of clotting factors and lead to DIC. Could say something about inflamm process

DIC to Sepsis – (patho 528) fibrin clots in circulation interferes with blood flow causing widespread organ hypo perfusion. May lead to ischemia and necrosis  infection  sepsis aggravate