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The Nature and Characteristics of Research

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NAME OF THE DRUG | GENERAL ACTION | SPECIFIC ACTION | INDICATIONS | CONTRAINDICATIONS | ADVERSE EFFECTS | NURSING INTERVENTIONS | Isoniazid200mg/5mL, 5.5mL OD, 30 minutes before meals | Antitiberculotic | Bactericidal: interferes with lipid and nucleic acid biosynthesis in actively growing tubercle bacilli. | * TB, all forms in which organisms are susceptible. * Prophylaxis in specific patient who are tuberculin reactors or household members of recently diagnosed tuberculars or who are considered to be high risk. | * Contraindicated with allergy to Isoniazid, Isoniazid-associated hepatic injury or other severe adverse reactions to isoniazid, acute hepatic disease. * Use cautiously with renal impairment. | * CNS: peripheral neuropathy, seizures, toxic encephalopathy, optic neuritis and atrophy, memory impairment, toxic psychosis. * GI: nausea, vomiting, epigastric distress, bilirubinemia, bilirubinuria, elevated AST, ALT levels, jaundice, hepatitis. * Hematologic: Agranulocytosis, hemolytic or aplastic anemia, thrombocytopenia, eosinophilia, pyridoxine deficiency, pellagra, hyperglycemia, metabolic acidosis, hypocalcemia, hypophosphatinemia due to altered vitamin D metabolism. * Hypersensitivity: fever, skin eruptions, lymphadenopathy, vasculitis. * Others: gynecomastia, rheumatic syndrome, SLE syndrome | Assessment * History: allergy to Isoniazid, Isoniazid-associated adverse reactions; acute hepatic disease; renal impairment * Physical: skin color, lesions; orientation, reflexes, peripheral sensitivity, bilateralgrip strength, ophthalmologic examination; adventitious sounds; liver evaluation; CBC, LFTs, renal function tests, blood glucose.Interventions * Give on an empty stomach, 1 hr before or 2 hrs after meals; may be given with food if GI upset occurs. * Give in a single daily dose. Reserve parenteral dose for patients unable to take oral medications. * Decrease foods containing tyramine or histamine in patient’s diet * Monitor liver enzymes monthly; risk of serious fatal hepatitis.Teaching points * Take this drug regularly; avoid missing doses; do not discontinue without first consulting your health care provider. * Do not drink alcohol, or drink as little as possible. There is an increased risk of hepatitis if this two drugs are combined. * Have periodic medical check-ups, including an eye examination and blood tests, To evaluate drug effects. * You may experience these side effects: nausea, vomiting, epigastric distress; skin rashes or lesions; numbness, tingling, loss of sensation. * Report weakness, fatigue, loss of appetite, nausea, vomiting, yellowing of skin or eyes, darkening of the urine, numbness or tingling in hands or feet. |

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