...Impact of Toxic chemical There are many materials used in the workplace that can be hazardous. However, in order for them to affect your health, they must contact the body or be absorbed into the body. When assessing the potential health effects from working with a particular material it is necessary to understand difference between "toxicity" and "hazard". 1. TOXICITY is the ability of a substance to produce an unwanted effect when the chemical has reached a sufficient concentration at a certain site in the body. The more toxic a material is, the smaller the amount of it necessary to be absorbed before harmful effects are caused. The lower the toxicity, the greater the quantity of it necessary to be absorbed. The toxicity of a chemical is generally measured by experiments on animals (quite often rats). If it is measured in terms of the amounts of material necessary to cause death in 50% of the test animals. These values are called LD50 (lethal dose) or LC50 (lethal concentration), and are usually given in weight of material per kg of body weight or airborne concentration of material per set time period respectively. 2. HAZARD is the probability that this concentration in the body will occur. Toxicity is an inherent property of the material. A material may be very toxic, but not hazardous, if it is handled properly and is not absorbed into the body. On the other hand, a material may have a very low toxicity, but be very hazardous. Example: 1. An open container...
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...Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms, mechanisms, detection and treatments of toxic substances, in particular relation to the poisoning of humans. It is difficult to discuss toxic phenomena at different levels of biological organisation separately because of complex relationship and interlinking between such levels. It should be noted that every biological level toxicology includes chemical and/or molecular toxicology in a sense. Scientists need to study natural situations to understand life processes and to investigate how introducing a particular substance can change living systems. It is often helpful to break a process into steps and then investigate how introduction of the substance affects each step. This first stage in toxicity assessment takes place in vitro. The investigator can pinpoint the various changes that could occur when a compound encounters a living cell and then make safety recommendations. Only a few substances successfully pass these initial trials. Those substances must then be tested further. Humans and other living things—plants, animals, and even molds and bacteria—are complex systems. The processes in any organism are far more complicated than just the sum of the individual parts. It is difficult to replicate at the lab bench the complex interactions. When safety is not assured, ethical research procedures restrict testing on...
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...developed to attempt to characterize the human health risks associated with exposure to chemicals. Exposure pathways Humans can be exposed to chemicals and physical agents through various exposure pathways. An exposure pathway describes the course that a substance takes from the source of chemical to be exposed individual. An exposure pathway generally consists of the following: 1. The source of the chemical 2. A medium (i.e. soil, water or air) 3. An exposure point, the...
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...Question 1 List and provide a brief discussion of the seven categories of toxic responses that a biological system may have. . There are seven categories of toxic responses: • Acute toxicity. This category is related to the immediate toxic responses that every biological system may have. This exposure of toxic substances for shorter duration and the diverse effect is high • Sub-chronic toxicity. This group results from exposure that is recurring numerous times. It is an ordinary human exposure type that occurs due to some pharmaceuticals or environmental agents. • Chronic toxicity. This relates to exposure of toxic substances for longer duration and the diverse effects are low. For instance, chronic bronchitis for tobacco addict and cirrhosis for alcohol addict • Carcinogenicity. This group refers to a complex abnormal process in cells which leads to cancer. • Developmental toxicity. This group refers to toxic responses to the developing embryo. This occurs due to the exposure of toxic substances to your partners prior to the act of conception. This leads to the death of cells of the fetus. • Genetic toxicity. The major cause of this kind of toxicity is a severe damage of DNA. This process is known as mutagenesis. It leads to cancer, or death of the cell. • Organ toxicity. This group is associated to toxic responses to different organs. It involves blood and cardiovascular toxicity, eye toxicity, dermal toxicity, reproductive toxicity, respiratory toxicity and various forms...
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...bacteria, viruses, fungi, protozoa and algae. Microorganisms are widespread in nature and are beneficial to life, but some can cause serious harm. They can be divided into six major types: bacteria, archaea, fungi, protozoa, algae, and viruses. Bacteria are unicellular organisms. The cells are described as prokaryotic because they lack a nucleus. They exist in four major shapes: bacillus (rod shape), coccus (spherical shape), spirilla (spiral shape), and vibrio (curved shape). Most bacteria have a peptidoglycan cell wall they divide by binary fission and they may possess flagella for motility. The difference in their cell wall structure is a major feature used in classifying these organisms. Bacteria can be further divided based on their response to gaseous oxygen into the following groups: aerobic is living in the presence of oxygen, anaerobic which means it is living without oxygen, and facultative anaerobes which can...
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...Each question is worth 10 points 1. Define the following terms a. Risk – the probability of a negative/harmful effect from a hazard or hazardous situation or the potential for the recognition of undesirable adverse consequences from future events. b. Risk Assessment – an examination and determination of the kind and magnitude of a hazard caused by an agent, where a particular group of receptors have been or may be exposed to the agent, and the present or potential future health risk that exists due to the agent. It is the combination of exposure assessment, health, and environmental effect data to estimate risks to human or environmental target organisms that may result from exposure to various hazardous substances. c. Risk Management – The process and procedures executed to mitigate or eliminate risk that has been discovered by a risk assessment. Measures or actions are taken to ensure that the level of risk to human health and/or the environmental do not exceed a prescribed risk level. Risk management focuses on decisions about whether a risk is sufficiently high to present public concern, the appropriate means for controlling the risks, and how to effectively use resources. 2. Define the following terms: d. RfD – Reference dose is an estimation of the daily oral exposure to a non-carcinogenic substance for the general human population that is likely to be without considerable risk of harmful effects during a lifetime. RfD establishes...
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...SECTION 1. POISONING IN THE EMERGENCY SETTING Definition A poison is any substance which, when taken into the body in sufficient quantity, may either endanger life or seriously impair body functions (IHCD 1999). Introduction Poisons come in many forms and can enter the body in many ways: Inhalation – fumes, gases; Ingestion – liquids or solids by mouth; Injection – needles, animal and insect bites; Absorption – pesticides or herbicides through the skin and eyes. In the field of accident and emergency we see cases of poisoning that are both accidental and intentional. A massive 85% of these cases involve just three types of drug: Paracetamol 45% Benzodiazepines 20% Antidepressants 20% (Daly; Harrison, 2001). As the majority of our cases come from these non-corrosive types of poisons the author will concentrate only on overdoses of drugs, with the second section solely devoted to the most common of these; Paracetamol. Clinical Signs of Poisoning The majority of drugs effect the nervous system and produce some common signs: ▪ Slow, shallow respiration’s ▪ Lethargy and reduction in activity ▪ Vomiting and diarrhoea ▪ Loss of consciousness Some drugs though, such as Paracetamol are asymptomatic during the early stages of poisoning. Although in the majority of cases our treatment in the field for poisoning will...
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...Medications 1. Protonix (pantoprazole) – antiulcer agent (proton-pump inhibitors) a. Indications – Erosive esophagitis associated with GERD. Decrease relapse rates of daytime and nighttime heartburn symptoms on patients with GERD. Pathologic gastric hypersecretory conditions. b. Action – Binds to an enzyme in the presence of acidic gastric pH, preventing the final transport of hydrogen ions into the gastric lumen. Diminished accumulation of acid in the gastric lumen, with lessened acid reflux. Healing of duodenal ulcers and esophagitis. Decreased acid secretion in hypersecretory conditions. Pg. 990 2. SynTHROID (levothyroxine) – hormones (thyroid preparations) a. Indications – Thyroid supplementation in hypothyroidism. Treatment or suppression of euthyroid goiters and thryroid cancer. b. Action – Replacement of or supplementation to endogenous thyroid hormones. Principal effect is increasing metabolic rate of body tissues: Promote gluconeogenesis, increase utilization and mobilization of glycogen stores, stimulate protein synthesis, promote cell growth and differentiation, aid in the development of the brain and CNS. Contain T3 (triiodothyronine) and T4 (thyroxine) activity. Replacement in hypothyroidism to restore normal hormonal balance. Suppression of thyroid cancers. Pg. 1219 3. Dulcosate Sodium (colace) – laxative (stool softener) a. Indications – prevention of constipation (in patients who should avoid straining...
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...appear a critical situation, this patient does not need to be quarantined, as we do not know if the antibodies present in his body are from a current infection or due to a vaccination. Measles and mumps antibodies are virus-specific proteins produced by the immune system in response to an infection by the measles or mumps virus, or in response to vaccination. There are two types of antibodies produced, IgM and IgG. The first type to appear in the blood after exposure or vaccination is IgM antibodies. Levels of IgM antibodies increase for several days to a maximum concentration and then begin to taper off over the next few weeks. IgG antibodies take a bit longer to appear, but once they do, they stay in the bloodstream for life, providing protection against re-infection. When measles or mumps IgG antibody is present in a person who has been vaccinated and/or is not currently ill, then that person is protected against infection (immune). If a person does not have measles or mumps IgG antibodies, then they are not considered immune to the viruses. This may be because they have not been exposed to the viruses, because the IgG has not had time to be produced, or because the person does not have a normal antibody response. 2. Describe how the clonal expansion theory explains the more rapid production of antigen specific antibodies, Helper T-cells and Cytotoxic T-cells, during a secondary infection. The clonal expansion theory, for which there is much evidence, suggests that...
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...Plant Defense Mechanisms Constitutive plant defense responses Are also called pre-existing or passive defense mechanism mediated by Cutin, waxes, Suberin hydrophobic materials that coat plant surfaces exposed to air prevents water loss and blocks pathogen entry and are high levels of toxic or feeding deterrent compounds. Always present and often species-specific and may exist as stored or conjugated compounds. Most secondary metabolites as defense are constitutive but some are also induced. Pre-existing (passive or constitutive) structural defense mechanisms Constitutive structural defense is achieved by constituents of cutin, waxes, and Suberin • Cutin o A macromolecule, a polymer consisting of many long-chain fatty acids (16:0 and 18:1 fatty acids with OH) o Component of cuticle, increase resistance; however, its thickness is not always correlated with resistance • Waxes o Not macromolecules, but complex mixtures of long-chain acyl lipids. o Forms a water-repellent surface and thereby prevent the formation of a film of water on which pathogens might be deposited and germinate (fungi) or multiply (bacteria). • Suberin o Polymer whose structure is poorly understood. o A principle component of outer cell walls of all underground organs and is associated with the cork cells of the periderm, the tissue that forms the outer bark of stems and roots during secondary growth of woody plants. o Suberin...
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...A variety of chemicals have been shown to disrupt female reproductive function throughout the lifespan in laboratory animals and humans (e.g., diethylstilbestrol). These effects include the disruption of normal sexual differentiation, ovarian function (i.e., follicular growth, ovulation, corpus luteum formation and maintenance), fertilization, implantation, and pregnancy. Only a few agents are associated with direct interference with the endocrine reproductive axis. Examples are those with estrogenic activity or the potential to interact with the aryl hydrocarbon (Ah) receptor. Exposure to toxicants during development is of particular concern because many feedback mechanisms functioning in the adult are absent and adverse effects may be noted at doses lower than those observed in the adult. Endometriosis is a painful reproductive and immunologic disease of women characterized by aberrant location of uterine endometrial cells. It affects approximately 5 million women in the United States from 15 to 45 years of age and often causes infertility. The etiology of this disease is unknown. In a single study with a small number of animals, research has suggested a link between dioxin exposure and the development of endometriosis in rhesus monkeys. The severity of this lesion was dependent on the dose administered. Recently, a small pilot study to test the hypothesis that serum dioxin concentrations have an association with human endometriosis has been reported. No statistically significant...
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...effective at increasing yield and killing pests but are often made with chemicals that can harm humans. A safer alternative to pesticides is genetically modified crops that use genes from other organisms to allow crops to adapt the traits of another plant that is resistant to the pest that attacks the initial crop. Bacillus Thuringiensis is a bacterium that is used in pest control, BT occurs naturally in soil and is toxic to herbivorous pests but completely safe to humans. The bacterium must be consumed by the pest, the protein will then be converted to its toxic form and destroy the gut of the insect. “Plants do not suffer from producing these proteins, which are toxic to insects.” (Collinge,2008) An unaffected crop that can defend itself from pests makes farming easier and more profitable. Crops will need less care and the yield will not falter if pests are dealt with by the crops themselves. Farmers will not have to pay for pesticides to maintain their crops and will have more crops to sell than before a pest control system was in place. With BT as the pest controlling agent farmers can advertise their product as free of pesticides and sell to a wider market. “Insects are responsible for the destruction of 25% of food crops worldwide annually”. (GMO, 2006) A worldwide consensus on genetically modified food crops would eliminate the unnecessary loss of 25% of food grown worldwide. Over 100 variations of the BT Toxin exist that each target a specific insect.(GMO, 2006) Crops need to...
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...Which of the following people is INCORRECTLY matched Click Link Below To Buy: http://hwaid.com/shop/which-of-the-following-people-is-incorrectly-matched/ Part 1 of 1 - Question 1 of 25 4.0 Points Which of the following people is INCORRECTLY matched with his/her environmental contribution? A.Rachel Carson: Silent Spring B.John Muir: Sierra Club C.Paul Ehrlich: The Population Bomb D.Theodore Roosevelt: Civilian Conservation Corps Part 1 of 1 - Question 2 of 25 4.0 Points DDT was sprayed in a Long Island salt marsh over a period of years for mosquito control. A portion of the food web is as follows: algae -> shrimp-> American eel -> Atlantic needlefish -> ring-billed gull In which organism would biological magnification be MOST evident? A.American eel B.Ring-billed gull C.Algae D.Shrimp Part 1 of 1 - Question 3 of 25 4.0 Points Which of the following statements about biogeochemical cycles is true? A.They only include processes conducted by or within living organisms. B.They pertain only to the abiotic environment. C.They describe the movement of water and other materials through an ecosystem. D.They only pertain to exchanges and interactions that occur within the atmosphere. Part 1 of 1 - Question 4 of 25 4.0 Points Which of the following would be a symptom of acute toxicity? A.asthma B.arthritis C.dizziness D.cancer Part 1 of 1 - Question 5 of 25 4.0 Points Which of the following series is organized in successive...
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...encourage their rapid growth. These organisms would then be able to break down the organic pollutant at a correspondingly faster rate. In fact, bioremediation is often used to help clean up oil spills. Bioremediation of a contaminated site typically works in one of two ways. In the case described above, ways are found to enhance the growth of whatever pollution-eating microbes might already be living at the contaminated site. In the second, specialized microbes are added to degrade the contaminants. Bioremediation provides a good cleanup strategy for some types of pollution, but as you might expect, it will not work for all. For example, bioremediation may not provide a feasible strategy at sites with high concentrations of chemicals that are toxic to most microorganisms. These chemicals include metals such as cadmium or lead, and salts such as sodium chloride. Nonetheless, bioremediation provides a technique for cleaning up pollution by enhancing the same biodegradation processes that occur in nature. Depending on the site and its contaminants, bioremediation may be safer and less expensive than alternative solutions such as...
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...Staphylococcal toxic shock syndrome Staphylococcus aureus is commonly found on the skin and mucous membranes of healthy adults and children and by age 25, 90% of the general population will have antibodies against the organism.1 Staphylococcal aureus is also known to be the causative agent to several infections that range from folliculitis, to abscess and endocarditis. In 1972, a syndrome of fever, myalgias, sore throat, edema, scarlatiniform rash, and desquamation associated with Staphylococcus aureus infection was first described. In 1978, Todd and colleagues reported seven cases in children who presented with similar symptoms as described in 1972 of fever, headache, conjunctival hyperemia, rash. These cases also presented with acute renal failure, hepatic abnormalities, DIC, and shock: “One patient died, one had gangrene of the toes, and all have had fine desquamation of affected skin and peeling of palms and soles.”3 Staphylococcus aureus was isolated from mucosal (nasopharyngeal, vaginal, tracheal) but not from blood and the term toxic shock syndrome (TSS) was coined.2,3 The peak incidence of Staphylococcus aureus related illness was seen in 1980 when 890 cases were reported, 91% of which were related to the use of super...
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