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Write An Essay On Paget's Disease

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Paget’s Disease
What is Paget’s Disease?
 Paget’s Disease of Bone (sometimes called Osteitis Deformans) is a chronic skeletal condition caused by unusually rapid bone destruction (osteolytic) and reformation (osteoblastic).
 Paget’s disease progresses very slowly and results in enlarged and deformed bones.
 The new bone formed can occur in several locations in the body and are always abnormal, dense and fragile.
 This unusual development may cause pain in bones, arthritis, fractures in the bone, and visible deformities.
 The disease is named after an English surgeon, Sir James Paget (1814 - 1899)
 There are 2 types of Paget’s Disease:
1. Monostotic (when a single region of bone is affected)
2. Polyostotic (when multiple regions …show more content…
 It is thought by both, doctors and scientists that a mixture of genetic and environmental factors are very common contributors to the disease. Several genes have determined to be associated with Paget’s disease e.g. Sequestrosome 1 gene on chromosome 5 .
 Paget’s Disease is inherited in approx. 1/3 of patients.
 It is believed by some scientists that Paget’s Disease is related to a viral infection in the bone cells, the osteoclast (responsible for absorbing bone tissue during growth & healing)
Risk Factors
 Although there is no known cause, there are factors that are known to increase the likelihood of contracting developing Paget’s Disease
 These include:
1. Age: it is believed that people > 55 years of age are more prone to developing Paget’s Disease.
2. Sex: men are more likely to develop the disease than women.
3. National Origin: Paget’s Disease is most common in Britian, central Europe, and Greece. It is very uncommon in Scandinavia and Asia.
4. Family History: A viral infection in the osteoclasts trigger Paget’s Disease in people who have already inherited the tendency to develop the condition.

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