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A Family with a History of Breast Cancer

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Submitted By futurenursejazz
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Breast and ovarian cancer are the most commonly diagnosed malignancies in North American, Caucasian women (Adkinson, 2012). Roughly more than 220,000 women are diagnosed every year (Adkinson, 2012) (National Library of Medicine (US), 2015). This disease is known to cluster within families if the BRCA1 and BRCA2 genes are involved. The mutation of these genes is more common in women than in men; however, the mutated genes have the ability to be inherited from the mother or the father equally. It is important to note that even though people, mainly women, inherit the mutated genes for breast and ovarian cancer; they do not inherit the disease itself. Rather, those that inherit the genes significantly increase their likelihood of breast or ovarian cancer developing later in life (National Library of Medicine (US), 2015).
Specifically, a woman’s risk for developing breast or ovarian cancer increases significantly if a first-degree relative has the disease. With a first-degree relative you share about 50 percent of their genes and this kind of relative includes parents, offspring, and siblings. Knowing this fact there is reason to believe that the genes responsible for the development of breast and ovarian cancer, BRCA1 and BRCA2, are strongly heritable in families and possess a high penetrance, or expression rate (Adkinson, 2012). The term used to describe this heritable genetic component is known as familial clustering. Though this disease is attributed to genetics there are other factors that influence the expression of breast and ovarian cancer. These factors include environment, socioeconomic status, and diet (Adkinson, 2012) (National Library of Medicine (US), 2015). The genetics of breast and ovarian cancer seem to link the genes among families as autosomal dominant, meaning that breast and ovarian cancer are not sex-linked diseases, but diseases that require

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