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Alterations of Thyroid Function

In:

Submitted By tcampbell01
Words 1277
Pages 6
Temeka Campbell
NURS 337
SEC 01
Instructor Susan Growe-Rosenthal, MSN/Ed, RN
Alterations of Thyroid Function
April 18, 2014

Abstract
Disorders of thyroid function develop as a result of primary dysfunction or disease of the thyroid gland, or secondarily, as a result of the pituitary or hypothalamic alterations. Both primary and secondary disorders result in some sort of alteration to the thyroid hormone (TH), thyrotropin-releasing hormone (TRH), and the thyroid-stimulating hormone (TSH). If these levels are elevated or showing inadequate production of the hormone, then the result would be hypothyroidism or hyperthyroidism. Of course there are underlying causes for these hormone levels to alter such as, thyrotoxicosis, Graves’ disease, and Hashimoto disease to name a few. This paper will describe the difference between hyperthyroidism and hypothyroidism.

The thyroid gland is the largest endocrine gland in the body. It is located in the anterior part of the neck, on the trachea just inferior to the larynx. Internally, the gland is composed of hollow, spherical follicles, which have follicle cells that produce thyroglobulin. Thyroid hormone (TH) derives from thyroglobulin. Thyroid hormone is referred to as the body’s major metabolic hormone. TH is actually two iodine containing amine hormones, thyroxine or T4 , and triiodothyronine or T3. TH is regulated through negative feedback loop involving the hypothalamus, the anterior pituitary, and the thyroid gland. TRH, which is synthesized and stored within the hypothalamus, initiates the loop. TRH is released into the hypothalamic-pituitary portal system and circulates to the anterior pituitary, where it stimulates the release of TSH. The primary effect of TSH on the thyroid gland is to cause an immediate release of stored TH and to increase TH synthesis. TH affects many body tissues and has a significant effect on

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