...50 Celiac Disease Dascha C. Weir, MD Ciaran Kelly, MD Celiac disease (CD) is an immune-mediated enteropathy secondary to permanent sensitivity to wheat gluten and related proteins in rye and barley. It results in characteristic histologic changes consisting of inflammation, crypt hyperplasia, and villous atrophy of the small intestine in genetically susceptible individuals. Significant variability in the clinical presentation of CD in the pediatric population complicates recognition of the disease in many patients. Treatment for CD consists of a lifelong strict gluten-free diet (GFD). Adherence to this diet is associated with resolution of most related signs and symptoms and a decreased risk of related complications. With an explosion of new knowledge over the span of two decades, our understanding of CD has changed dramatically. CD has gone from a rare condition causing gastrointestinal symptoms in children of European origin to a common disorder causing symptoms that affect multiple organ systems in all ages virtually worldwide.1 The overall prevalence of CD is similar in Europe and North America affecting up to 1% of the population.2,3 A large multicenter study in the United States, using serologic screening with biopsy confirmation to identify cases of CD, showed a prevalence of CD of 1:133 in individuals with no evident risk factors. Prevalence of CD in symptomatic patients was 1:56. The prevalence of diagnosed CD is much lower, especially in the...
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...Celiac is an autoimmune disease that causes hypersensitivity to gluten. It occurs when a person eats gluten, and their body issues an immune system attack which damages the villi in the small intestine. Damaging the villi results in the difficulty of nutrient absorption into the body. Celiac was first found by Aretaeus of Cappadocia around 8,000 years ago, and named it “Koiliakos” after the Greek word “koelia”, which means abdomen. Samuel Gee provided the first modern description of the disease in 1887, and was the first to suggest a dietary treatment to the disease. Willem Dicke, in 1947, noticed during the Dutch famine there was a lack of bread, and celiac patients improved. This led to the popularization of the gluten-free diet. There are...
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...Celiac disease is an autoimmune disorder that affects the immune system of the host. It causes damage to the small intestine if the person ingests even a small crumb of something that contains the protein ‘gluten’. Gluten can be found in barley, oats, rye, and wheat. It is very common that people who have celiac disease don’t even know it. Worldwide, it affects 1 in 100 people and in the U.S. two and a half million people are undiagnosed and are very much so at risk. The longer you go without knowing you have the disease, it can cause an even high chance of not being able to reverse the damage done to the small intestine. When gluten is ingested into the body, for some peculiar reason the immune system registers the protein as something harmful to the...
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...Daniel Edelman Science E Period April 6, 2016 Celiac Disease Celiac disease, also known as celiac sprue or gluten-sensitive enteropathy, is an autoimmune disease that affects the small intestine and sometimes also the stomach. Celiac disease is hereditary, passed down genetically through families; if a person has a member in the immediate family who has celiac disease, they are more likely to have celiac disease also - there is no way to prevent celiac disease. Approximately 1 percent of the American population has celiac disease, and the disease mainly affects people of European descent. Celiac disease typically affects more women than men, by a small percentage. Celiac disease affects at least 3 million Americans, but most cases are undiagnosed, or misdiagnosed....
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...Is celiac disease a legitimate ailment or a propaganda used my the media machine to throttle views and sell tabloids? Well simply put, it is a combination of the two; celiac diseases has been getting a lot of media coverage due to its association with the gluten-free diet and the proposed benefits of implementing it in one's lifestyle. In essence, celiac disease is an immune-mediated systemic disorder; people who suffer from the ailment are unable to digest gluten, a protein found in common food substances. Celiac disease causes different symptoms such as Diarrhea, Iron and Vitamin D deficiency, weight loss, anemia, and osteoporosis. Celiac disease may be indulged to some as vogue; however, it is a major disorder, which alters the lives of...
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...Celiac Disease By Ella Jeanseau, Due April 13th, #25 For years, people have depended on gluten to thicken and bind all types of foods such as sauces, bread, pastries, and much more. There are so many delicious foods to eat, but for people with Celiac Disease (CD), using gluten is not an option. Gluten is a mixture of proteins found in Wheat, Barley, Rye, and Malt. When people with the autoimmune disorder, CD, digest gluten, the immune system attacks, and causes damage to the lining in the small intestine. CD has been a particularly new subject to studying doctors over the past years. Researchers are still trying to find more details on how CD is working. Some say it may be related to a type of “gut bacteria”...
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...life-devastating disease is named Celiac Disease. It affects the broad spectrum of all ages, starting from the probability of birth, and finishing with the duration of the lifespan of the individual. Nowadays, food allergies, ADHD, diabetes, and among them, Celiac Disease, have arisen from improper diet and inferior nutrition. Partially, these diseases have been caused by traditional foods which have been modified to suit the current production and retail necessity. Celiac Disease has been known for many centuries. Perhaps one of the first descriptions of it was drafted by Greek physician Aretaeus the Cappadocian in the second century AD: The stomach being the digestive organ, labors in digestion when diarrhea seizes the patient. If this diarrhea does not proceed from a slight cause of only one or two days’ duration, and if, in addition, the patient’s general system be debilitated by...
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...Celiac Disease What is Celiac disease? Celiac disease is an autoimmune disorder that can occur in people who are genetically predisposed. Celiac disease runs in families so if you have a family member with it then you have a 1 in 10 chance of having it as well. This disease is said to affect approximately 1 in 100 people worldwide. There are at least 2 in a half million Americans who are undiagnosed and are at risk of having long term health problems. Celiac disease can be contracted at any age once a person starts taking medicine or eating foods that contain gluten. If it is left untreated, it can lead to more major health problems. Presently, the only known treatment for celiac disease is lifelong devotion to a strict gluten-free diet. People living gluten free must avoid foods with wheat,...
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...Celiac Disease is a genetic autoimmune disorder, affecting as much as one in 100 people worldwide; two and a half million people go undiagnosed at this time. Celiac Disease affects more than one bodily system when untreated. While the symptoms are vast, the disease is incurable and lifelong, but also comes with many forms of treatment to improve quality of life. Many are unaware that the disease even exists, but it is important to be educated on a disease that affects so many and can be deadly. Celiac Disease is the immune systems negative response to eating gluten. Over time, the inflammation from the immune response damages the small intestine’s lining, preventing absorption of nutrients in food. The small intestine is lined with small...
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...Research indicates celiac disease (CD) is a common, yet little-recognized, cause of female hormone imbalance. Before we talk about imbalance, let’s look at what hormones are and what they do. Hormones are powerful chemicals produced by endocrine glands throughout the body. Once released, hormones travel via the bloodstream to carry messages to various body structures such as organs, tissues and cells. Once a hormone makes it to the target site and its message is received, various chemical reactions are triggered. For example, certain hormones help us metabolize the foods we eat, while others help us maintain a healthy and consistent body temperature. With all that goes on inside the human body, any imbalance could throw off the entire system....
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...About Celiac Disease Celiac disease is an autoimmune disease that shows an intolerance to the proteins found in wheat, rye or barley. This disease damages your digestive system to where nutrients can no longer be absorbed. This malnourishment leads to many more complications to a person’s health. It affects nearly 3 million americans and many more report having symptoms of this, or a gluten sensitivity. The symptoms of Celiac have been described back in the second century. People reported of an irritated stomach and an upset digestive tract. In 2000, a skeleton of a lady from the first century was examined. She was around eighteen years old at the time of her death and was reported to have been “malnourished and failed to thrive,” two common...
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...Celiac Disease Celiac disease is a complication people have with consuming the gluten protein. When gluten is consumed, it triggers an unusual immune response, and damages the small intestine which will not allow it to absorb nutrients. According to the National Foundation for Celiac Awareness (NFCA), “An estimated 1 in 133 Americans, or about 1% of the population has this disease.” Celiac disease is not a popular condition, but it can impact a person’s life immensely. It is a genetic disorder, which means, it can effect an entire family. Since celiac disease has no cure, the effected can become more aware of their symptoms and treatment options, along with clean, gluten-free eating habits. Symptoms for celiac disease are very spontaneous, and may vary depending on an individual’s lifestyle habits. According to WebMD, “When the small intestine fails to absorb nutrients, a person may experience gas, abdominal swelling, bloating, and mild stomach pain.”...
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...In chapter 6 on page 124, what I found interesting was how 1 percent of people in the United States and Canada have Celiac disease “a disorder in which the body can’t tolerate gluten, a protein found in wheat, rye, barley, and sometimes oat”(Clark 124). I heard of this disease but never knew 1 percent of people had it and as I was reading, what caught my attention was how Celiac disease symptoms is difficult to detect and it vary from person to person, which is scary to know because somebody could have it and not know what the symptoms are could be dangerous. Also I learn that the disease in those people, activate gluten intestinal inflammation where damages in the small intestine occur, where it interfere with absorption of nutrients like calcium and iron which is serious because if no iron is absorbed it leads to anemia and if no calcium is absorbed it leads to osteoporosis....
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...indigestible for many people but I didn't know the actual name of the disease. While reading through the case studies, Celiac disease just sounded like it pertained to the gastrointestinal tract because I had it confused with Colic, which is along the lines of intestinal obstruction or abdominal pain due to intestinal gas, mainly in infants. The pathophysiology of a disease is often a little difficult to write in a way that all reader can comprehend in one go. I was a little confused with how exactly gluten intolerance begins and whether or not does lupus in the family predispose Rhonda to celiacs disease specifically. After researching about genetic predisposition, I feel like I learned too much because of the insane amount of information out on the web. The medical field has advanced immensely, but even today, we don't have many of the answers. The human body has a very complex and effective immune system that will rise to injurious conditions and get rid of any harmful...
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...Celiac Disease: What? Who? How? Celiac Disease: What? Who? How? Life changing, life long, no cure! This paper is to give knowledge and inform readers on what Celiac Disease is, who it effects, what it affects, and try to explain how it can interrupt a normal, life style to where most of us take for granted. Have you ever wondered what life would be like if you found out you could not eat normal everyday foods that most of us take for granted? What if one day you woke up and found out you could not eat something as simple and as popular as pizza? That you could not eat bread, cake, cookies, lasagna, spaghetti, or even drink beer? That every time you did, you would get sick. Well, for a growing percentage of Americans, that is what is becoming a reality. What is it? How do you get it? What does it do to you? Who can get it? These are just some of the questions I will be answering in this paper. What is Celiac Disease? Well that’s a very good question. Celiac Disease or Gluten-Sensitive Enteropathy is a disease of the intestinal tract. It is a chronic tropical disease of intestinal malabsorption or in simple terms, an allergy to wheat products such as wheat, rye, barley, and oats (Reilly 116). Celiac Disease is a lifelong disease that can only be controlled by understanding CD and following a lifelong diet which excludes wheat, barley, and rye. Celiac Disease is a multisystem disorder that causes the body’s immune system to respond to proteins in certain grains which damage...
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