...Investigational New Drug (IND) review process begins from the time the sponsor files investigation new drug application and the purpose of the review is to confirm the safety and efficacy of the patient for the drug. Moreover in the process of review if the review committee notifies any deficiencies by the new drug then there will be a clinical however if there are no deficiencies the drug will be approved for new drug application and will be under continuous review to make sure , that the drug does not cause any potential harm. This entire step wise process of review is explained in the following paper INVESTIGATIONAL NEW DRUG REVIEW PROCESS The following flow chart gives an overview of the IND review process Applicant (Drug Sponsor) IND Review by CDER Statistical Pharmacology/ Toxicology Medical Chemistry Sponsor Submits New Data Safety Review Safety acceptable for study to proceed Clinical Hold Decision Notify Sponsor Complete reviews Reviews Complete and Acceptable? Sponsor Notified of Deficiencies No Deficiencies Study Ongoing INVESTIGATIONAL NEW DRUG REVIEW PROCESS I. Applicant (Drug sponsor): An applicant or the sponsor is a person or a group who takes responsibility and initiates for the investigation of new drug. A person other than an individual that uses one or more of its own employees to conduct an investigation that it has initiated is a sponsor. The sponsor may be an individual, partnership...
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...Physical chemistry is the study of macroscopic, atomic, subatomic, and particulate phenomena in chemical systems in terms of laws and concepts of physics. * Chemical kinetics, also known as reaction kinetics, is the study of rates of chemical processes. Chemical kinetics includes investigations of how different experimental conditions can influence the speed of a chemical reaction and yield information about thereaction's mechanism and transition states, as well as the construction of mathematical models that can describe the characteristics of a chemical reaction. * Chemical physics is a subdiscipline of chemistry and physics that investigates physicochemical phenomena using techniques from atomic and molecular physics and condensed matter physics; it is the branch of physics that studies chemical processes from the point of view of physics. * Electrochemistry is a branch of chemistry that studies chemical reactions which take place in a solution at the interface of an electron conductor (theelectrode: a metal or a semiconductor) and an ionic conductor (the electrolyte). * Femtochemistry is the area of physical chemistry that studies chemical reactions on extremely short timescales, approximately 10–15 seconds (one femtosecond, hence the name). The steps in some reactions occur in the femtosecond timescale and sometimes in attosecond timescales,[1] and will sometimes form intermediate products. * Geochemistry is the science that uses the tools and principles...
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...CHEMISTRY CHEMISTRY (CLASSES XI–XII) Rationale Higher Secondary Stage is the most crucial stage of school education because at this stage specialised discipline based, content oriented courses are introduced. Students reach this stage after 10 years of general education and opt for Chemistry with a purpose of mostly for pursuing their career in basic sciences or professional courses like medicines, engineering, technology and studying courses in applied areas of science and technology at tertiary level. Therefore, at this stage, there is a need to provide learners with sufficient conceptual background of Chemistry, which will make them competent to meet the challenges of academic and professional courses after the higher secondary stage. National Curriculum Framework for School Education – 2005 recommends a disciplinary approach with appropriate rigour and depth with the care that syllabus is not heavy and at the same time it is comparable to the international level. It emphasizes a coherent focus on important ideas within the discipline that are properly sequenced to optimize learning. It recommends that theoretical component of Higher Secondary Science should emphasize on problem solving methods and the awareness of Syllabus for Secondary and Higher Secondary Levels 22 historical development of key concepts of science be judiciously integrated into content. The present exercise of syllabus development in Chemistry at Higher Secondary Stage is based on this framework...
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... Molecules can be either organic or inorganic. In chemistry terms, organic means a molecule has a carbon backbone, with some hydrogen’s thrown in for good measure. Living creatures are made of various kinds of organic compounds. Inorganic molecules are composed of other elements. They can contain hydrogen or carbon, but if they have both, they are organic. An organic compound is any member of a large class of chemical compounds whose molecules contain carbon and hydrogen; therefore, carbides, carbonates, carbon oxides and elementary carbon are not organic. An inorganic compound is a chemical compound that is not an organic compound. Inorganic compounds come principally from mineral sources of non-biological origin. The modern definition of inorganic compounds often includes all metal-containing compounds, even those found in living systems. Although most carbon compounds are classed as organic, cyanide salts, carbon oxides and carbonates are usually considered to be inorganic. The terms "organic" and "inorganic," as applied to the various kinds of matter of which the universe is composed, had, to begin with, a very definite signification; the latter being applied to all those forms of matter which exist independently of the operation of living beings, whilst all kinds of matter produced by the vital chemistry of living beings were grouped together under the former title. "Inorganic" Chemistry. At the present day, the term "organic" has...
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...CARIBBEAN EXAMINATIONS COUNCIL Caribbean Secondary Education Certificate CSEC® CHEMISTRY SYLLABUS Effective for examinations from May–June 2015 CXC 21/G/SYLL 13 Published by the Caribbean Examinations Council. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form, or by any means electronic, photocopying, recording or otherwise without prior permission of the author or publisher. Correspondence related to the syllabus should be addressed to: The Pro-Registrar Caribbean Examinations Council Caenwood Centre 37 Arnold Road, Kingston 5, Jamaica Telephone Number: + 1 (876) 630-5200 Facsimile Number: + 1 (876) 967-4972 E-mail Address: cxcwzo@cxc.org Website: www.cxc.org Copyright © 2013 by Caribbean Examinations Council The Garrison, St Michael BB14038, Barbados CXC 21/G/SYLL 13 Contents RATIONALE ................................................................................................................................... AIMS ............................................................................................................................................. CANDIDATE POPULATION ............................................................................................................. SUGGESTED TIME-TABLE ALLOCATION ........................................................................................ ORGANISATION OF THE SYLLABUS .................................................
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...Subject Area: Chemistry Grade Level: Middle School Chemistry Lesson Title: Chlorophyll Chromatography National Science Education Standards: Science as Inquiry: 5–8 • Properties and Changes of Properties: 5–8 Suggested Prior Knowledge: concepts of solutions, mixtures, separation of mixtures, solubility Purpose: To give students an understanding of paper chromatography and to allow students to separate a mixture of pigments extracted from leaves. Key Vocabulary: absorbent—material used in chromatography that will attract and absorb the compounds being separated chlorophyll—one of many pigments used by plants to absorb energy from sunlight in the process of photosynthesis chromatography—method used to separate a mixture of compounds based on differing solubilities of the compounds in the solvent being used eluent (solvent)—material used in chromatography which carries the compounds to be separated through the absorbent photosynthesis—process by which plants convert energy from sunlight, water, and carbon dioxide gas into sugar solute—substance dissolved in a solution solution—homogeneous mixture of two or more substances solvent—substance dissolving the solute in a solution Objectives: 1. Students will be able to design and carry out an investigation to separate the pigments from a leaf by paper chromatography. 2. Students will identify a mixture by separating it into different compounds. Materials: ...
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...The Relation between Forensic Science and Chemistry Isabelle Génier London Central Secondary School There is a great number of careers that involve chemistry; being a forensic scientist is one of them. What is a forensic scientist you ask? That is a very difficult question to answer. Generally they provide evidence in court to support the prosecution or defence in criminal and civil investigations. The evidence can be provided in the form of a written paper or the scientist might be called to testify during trials or hearings as an expert witness on evidence or laboratory techniques. There are different areas of forensic science such as chemistry (which involves crimes against property), biology (which involves crimes against people), and toxicology (which majorly involves drugs). Being a forensic scientist involves many tasks, they go to crime scenes to investigate and then plan what evidence they need to collect. Afterwards they return to compile, catalogue, and preserve evidence to help solve the case. They then do a sketch of the scene so that they can later reconstruct the crime scene to re-examine, test, and analyze the evidence. Now that the evidence has been assessed, it can be discussed between specialists and a report can be written based on their conclusions. The report is used during trials or hearings; however, the forensic scientist can also be called upon to personally testify as an expert witness. This career, which used to be an unknown field has now...
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...Flammability: 0; Reactivity: 0 | REFRACTIVE INDEX | | FLASH POINT | 180 C | STABILITY | Stable under ordinary conditions. | GENERAL DESCRIPTION & APPLICATIONS | Amide is a group of organic chemicals with the general formula RCO-NH2 in which a carbon atom is attached to oxygen in solid bond and also attached to an hydroxyl group, where 'R' groups range from hydrogen to various linear and ring structures or a compound with a metal replacing hydrogen in ammonia such as sodium amide, NaNH2. Amides are divided into subclasses according to the number of substituents on nitrogen. The primary amide is formed from by replacement of the carboxylic hydroxyl group by the NH2, amino group. An example is acetamide (acetic acid + amide). Amide is obtained by reaction of an acid chloride, acid anhydride, or ester with an amine. Amides are named with adding '-ic acid' or '-oic acid' from the name of the parent carboxylic acid and replacing it with the suffix 'amide'. Amide can be formed from ammonia (NH3). The secondary and tertiary amides are the compounds which one or both hydrogens in primary amides are replaced by other groups. The names of secondary and tertiary...
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...Clader et al (J. Med. Chem. 1996, 39, 3684-3693) reported a series of azetidinone cholesterol absorption inhibitors related to compound 2(6 in paper). They focused on detailed structure-activity relationship of azetidinone compounds to probe the effect and sensitivity of the nature and pattern of substitution on the hypocholesterolemic activity in 7-day cholesterol-fed hamster model. Investigation identified that 4-alkoxyphenyl and absolute stereochemistry at C-4 (compound 23), well placed phenylalkyl group (compound 105) and monosubstitution at C-3, an aryl group at N-1 irrespective of substitutions (compound 65) and azetidinone scaffolds is essential for the in vivo CAI activity. Compound 23 Compound 105 Compound 65 Compound 6 X- 4-C2H5O X- OCH3 R- H X- 4-CH3O R1- Ph(CH2)3 Y- H R1- Ph(CH2)3 R2- H R1- F R2- Ph(CH2)3 R2- H SC- -52%(50mg/kg/day) -30%(50mg/kg/day) -49%(50mg/kg/day) -29% (50mg/kg/day) LCE- -98%(50mg/kg/day) -94% (20mg/kg/day) -95%(40mg/kg/day) -77.5%(50mg/kg/day) ...
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...his doctorate after transitioning from school to school, he created the Haber-Bosch process which combined nitrogen and hydrogen to form ammonia, and he supervised the German poison gas program during World War I. At the University of Berlin, in 1886, Haber began his study of chemistry. After transferring to many different colleges and even spending a year in the military, he earned his doctorate from the University of Berlin in 1891. He earned this while working at the college with Liebermann on organic compounds. Haber was given the position of an assistant in the Department of Chemical and Fuel Technology at the Fridericiana Technische Hochschule. During his work as an...
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...computerized (font: Times New Roman/font size: 12) Reading assign. Measurement Diff. system of measurement fundamentals and derive quantities scientific notation rules in significant figures conversion of units http://www.hep.man.ac.uk/babarph/babarphysics/physicists.html ) I.1 Science The intellectual and practical activity encompassing the systematic study of the structure and behaviour of the physical and natural world through observation and experiment. I.2 The Branches of Science The Physical Sciences * Physics: The study of matter and energy and the interactions between them. Physicists study such subjects as gravity, light, and time. Albert Einstein, a famous physicist, developed the Theory of Relativity. * Chemistry: The science that deals with the composition, properties, reactions, and the structure of matter. The chemist Louis Pasteur, for example, discovered pasteurization, which is the process of heating liquids such as milk and orange juice to kill harmful germs. * Astronomy: The study of the universe beyond the Earth's atmosphere. The Earth Sciences * Geology: The science of the origin, history, and structure of the Earth, and the physical, chemical, and biological changes that it has experienced or is experiencing. * Oceanography: The exploration and study of the ocean. * Paleontology: The science of the forms of life that existed in prehistoric or geologic periods. * Meteorology: The science that deals with the atmosphere...
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...There are many ways to examine the subject of alchemy, including alchemy as a source of symbolism, psychology, and mysticism. It has also been an influence on the world view of various writers, artist, and musicians. The focus of this report is alchemy as a pre-chemistry, which gave a new impulse towards the preparation of medicinal remedies and also was a major influence on today's scientific investigations. Alchemy is an ancient art, practiced in the Middle Ages. The fundamental concept of alchemy stemmed from Aristotle's doctrine that all things tend to reach perfection. Because other metals were thought to be less perfect than gold, it was reasonable to believe that nature created gold out of other metals found deep within the earth and that a skilled artisan could duplicate this process. It was said that once someone was able to change, or transmute a "base" chemical into the perfect metal, gold, they would have achieved eternal life and salvation. In this way, alchemy turned into not only a scientific quest, but a spiritual quest as well. Although the purposes and techniques were often times ritualistic and fanciful, alchemy was in many ways the predecessor of modern science, especially the science of chemistry. The birthplace of alchemy was ancient Egypt, where, in Alexandria, it began to flourish during the Hellenistic period. Also at that time, a school of alchemy was developing in China. The writings of some Greek philosophers may be considered to be among the very...
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...Studying biochemistry at university will give me a unique and rewarding opportunity to be a part of this development which is my principle desire. Studying triple science at GCSE, I was able to study all three sciences separately where I experimented and chose my favourite subjects. Contextualising theoretical lessons into practical lessons has been extremely enjoyable as I have the chance to see the things I learnt with my own eyes. I particularly enjoyed doing titrations during my laboratory lessons in chemistry. Discovering the book "Genome" by Matt Ridley resulted in questions in my head such as 'how is a simple chemical compound, DNA, so powerful'? How does chemistry allow the formation of complex molecules and help the heart beat? Being particularly attracted to my biology and chemistry lessons I realised that both subjects are the key facets that generate intelligence and development....
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...Synthesis of Acetanilide and Purification by Recrystallization Par, B., Ramos, S., Reynaldo, H., Roque, P., Servidad, Y., and Soriente, P. 2D-Pharmacy, Group No. 7, Department of Pharmacy, Faculty of Pharmacy, University of Santo Tomas, España Boulevard, 1015 Manila, Philippines Abstract Recrystallization is the primary method of purification used to isolate organic compounds in a supersaturated solution by the difference of solubility at different temperature that results to the separation of the compound from the solution. The purpose of this experiment is to synthesize acetanilide by the acetylation of aniline and to obtain pure acetanilide by purification of the collected crude acetanilide by crystallization. The recrystallizing solvent was chosen among ethanol, water and hexane. The acetanilide was synthesized and formed by acetylation of aniline and acetic anhydride, and it was then cooled to hasten the formation of crystals. After cooling, the mixture was filtered and dried to obtain the crude acetanilide. The crude acetanilide and the chosen recrystallizing solvent was mixed and heated in the water bath until the solid dissolved. The solution was filtered while hot and its filtrate was cooled in an ice bath. The filtrate was then filtered to collect the crystal residue formed. The crystals were washed with distilled water and allowed to dry to obtain the pure acetanilide. The weight of pure acetanilide was measured and the melting point of the pure acetanilide...
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...Chemical Monitoring and Management Part 1 - Chemical Occupations a) Analytical Chemist – uses a various methods to investigate the chemical nature of substances. Their aim is to identify and understand the substance and how it behaves in different conditions. b) Clinical Biochemist – analyses and interprets data relating to patients’ samples to assist with the investigation, diagnosis and treatment of diseases. c) Forensic Scientist – provides impartial scientific evidence for use in courts of law to support the prosecution or defence in criminal and civil investigations. d) Toxicologist - plans and carries out laboratory and field studies to identify, monitor and evaluate the impact of toxic materials and radiation on human and animal health, the environment, and the impact of future technology. e) Process engineer – develops economical industrial processes to make the huge range of products on which modern society depends, including food and drink, fuel , artificial fibres, pharmaceuticals, chemicals, plastics, toiletries, energy and clean water. * Calorimetry * Chromatography * Spectroscopy Analytical Chemist – uses a various methods to investigate the chemical nature of substances. Their aim is to identify and understand the substance and how it behaves in different conditions. They use different types of analysis including: * Gravimetric analysis * Qualitative analysis * Thermal analysis * Volumetric analysis ...
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