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Genetics

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Genetics, Brain Structure, and Behavior: Future Directions

While there are many disorders or illnesses that involve genetics, brain structure and behavior the most fascinating is Parkinson’s disease. In this paper the following information will be approached, what defines the illness of Parkinson’s disease, how Parkinson’s disease can change the structure of the brain and an individual’s behavior, what the current problems with diagnosing Parkinson’s disease are, what the current issues are with the preventive therapies related to Parkinson’s, what are the future therapies that may be used to diagnose and treat Parkinson’s. The last thing that will be discussed is any questions that are left to be answered about Parkinson’s that is to say what the scientific and medical field do not know about Parkinson’s. According to "Pubmed Health" (2013), “Parkinson's disease is a disorder of the brain that leads to shaking (tremors) and difficulty with walking, movement, and coordination.” Also according to “Pubmed Health” (2013), “nerve cells use a brain chemical called dopamine to help control muscle movement. Parkinson's disease occurs when the nerve cells in the brain that make dopamine are slowly destroyed. Without dopamine, the nerve cells in that part of the brain cannot properly send messages. This leads to the loss of muscle function. The damage gets worse with time. Exactly why these brain cells waste away is unknown.” There are several symptoms of Parkinson’s disease and they are blinking slowly, constipation, difficulty swallowing, drooling, problems with balance and walking, muscle aches and pains, movement problems, ridged or stiff muscles (usually starts in the legs), shaking (also called tremors), slowed speech, stooped position, and low blood pressure upon standing. According to “Pubmed Health” (2013), a few less common symptoms of Parkinson’s disease include “anxiety, stress, tension, confusion, dementia, depression, fainting, hallucinations, and memory loss.” One treatment for Parkinson’s disease includes a medication that tries to replace the dopamine that the illness is destroying, but there have been problems related to impulsive behavior with this medication. According to Parkinson's Disease Foundation (2014), “Parkinson’s medications can effectively control movement symptoms of the disease. But for a small percentage of people they can have a surprising side effect: they can lead a person to develop irresistible and destructive impulses related to gambling, hypersexuality, and abuse of anti-Parkinson’s medications, shopping, eating, and other activities.” If these behaviors are not addressed there are several bad outcomes such as divorce, overwhelming and even catastrophic debt, sexually transmitted diseases, or other such unwanted effect. While the impulsive behavior may not be something that everyone with Parkinson’s experiences it is definitely something that friends, loved ones, and care givers should be on the lookout for when this medication is started or increased. As with any disease or illness there can sometimes be problems diagnosing said illness there is no exception with Parkinson’s disease. According to University of Maryland Medical Center (2011), “there is no diagnostic test that can confirm Parkinson's disease. Laboratory testing of the blood of patients with the symptoms typical of Parkinson's only rarely uncovers any abnormality. Electroencephalograms (EEGs) record some aspects of brain electrical activity, but they are not effective in spotting Parkinson's. The MRI and CAT scans of the brain produce remarkable and exquisite anatomic pictures. The MRI and CAT scans of the brain of people with Parkinson's disease appear normal. The brain of people with Parkinson's disease appears normal.” Due to the fact that all the diagnostic tests are not effective in diagnosing Parkinson’s patients who are suspected to have this illness have to rely on the expertise of his or her doctor. With all of the articles that are written about Parkinson’s disease the main treatment seems to be medication, especially those used to replace dopamine. The problem with this is that while the medicine will help the symptoms of Parkinson’s it will not cure it, because there is no known cure for Parkinson’s. Another problem with the medication is that with any medication the side effects of the drugs can be more damaging than the actual disease. According to "Pubmed Health" (2013), “many medications can cause severe side effects, including hallucinations, nausea, vomiting, diarrhea, and delirium.” While still not being a cure some other treatments that are used alongside medication are lifestyle changes and surgery. Lifestyle changes can be things like diet, exercise, therapy (physical, occupational, and speech), the use of assistive devices (walkers, wheelchairs, wall bars), and the assistance of social workers in dealing with daily struggles. Surgery may be an option as well for the treatment of the symptoms of Parkinson’s according to “Pubmed Health” (2013), “deep brain stimulation involves placing electrical stimulators in specific areas of the brain that control movement.” Preventive therapies for Parkinson’s disease seem nonexistent and this is only evident due to the fact that since it is not known what causes the illness. It is hard to know how to prevent something if you do not know what the cause of it was in the first place. It would make it easier to develop early testing for Parkinson’s if the cause was evident. Future therapies are being developed and clinical trials are always being help for the cause and prevention of Parkinson’s. Right now in this point in time the thing that the scientific and medical field do not know about Parkinson’s is the cause, while they are trying to understand this debilitating disease all that can be done is to continue to treat the symptoms. If the cause of Parkinson’s was discovered that would be amazing and could ultimately lead to the development of a cure. To recap Parkinson’s disease is a brain disorder that affects motor control especially balance and movement. The distinguishing factor that defines Parkinson’s disease is the wasting away of the part of the brain that controls dopamine production. The medications used to treat the symptoms of Parkinson’s disease can cause some serious side effects one being impulsive behavior. There are no laboratory tests that confirm the diagnoses of Parkinson’s disease. The three things that are used to treat the symptoms of Parkinson’s are medication, lifestyle changes, and surgery. There are not any preventative therapies for Parkinson’s disease, because the cause of the disease is not known. Clinical trials are constantly being held to study the cause and prevention Parkinson’s. The scientific and medical field need to know the cause of Parkinson’s disease in order to more effectively find a cure.

References

PubMed Health. (2013). Retrieved from http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001762/

Parkinson's Disease Foundation. (2014). Impusive Behavior. Retrieved from http://www.pdf.org/en/impulsive_behavior

University of Maryland Medical Center. (2011). Diagnosis of Parkinson's Disease. Retrieved from http://umm.edu/programs/parkinsons/health/diagnosis

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