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Glutamates Research Paper

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L-glutamic acid plays a key role in the metabolism of amino acids. The key steps in the cell metabolism in all organisms are the synthesis of both glutamate and glutamine. This is because they denote the only means of incorporating inorganic nitrogen into carbon backbones. Inorganic nitrogen is assimilated in the form of ammonium, which is incorporated as an amino group to glutamate or an amido group to glutamine. In particular, the amino group of glutamate is used in the synthesis of pyrimidines, purines, histidine, asparagine, tryptophan, NAD, p-aminobenzoate and amino sugars.
Glutamate is a non-essential amino acid that can be synthesized in the body through different metabolic pathways. Glutamate can be synthesized by two alternative routes which involve catalysis of GDH in the aminating direction, or via participation of two enzymes; glutamate synthethase (GS) and glutamate synthase or also termed glutamine oxoglutarate aminotransferase (GOGAT). …show more content…
Glutamate also serves as a key precursor or substrate for synthesis of amino acids, nucleic acids, nucleotides and metabolites (Wakabayashi et al., 1991; Battaglioli et al., 2003). Glutamate is synthesized from α-ketoglutarate, glutamine and 5-oxoproline (Hu et al., 2010). In addition, glutamate also synthesized the excitatory, N-acetyl-L-aspartyl-L-glutamate and inhibitory neurotransmitter, γ-aminobutyrate and the antioxidant, glutathione (Dringenand Hirrlinger, 2003). Therefore, glutamate is of massive attention as it is involved in different metabolic

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