...The desert hedgehog gene is a key gene to the human reproductive system. It plays a vital role in the development of important sexual organs. Along with the other hedgehog proteins, the hedgehog protein family and signaling pathway are also important to the overall development of many parts and systems of the human body. Each protein within the family has its own role to play in overall expression of cells and growth. There are a total of three proteins within the family; the Indian hedgehog (IHH), the sonic hedgehog (SHH), and the desert hedgehog (DHH) gene. The term hedgehog refers to the terminal domains within the genes of this family. The “hog” domain makes up the C-terminal of the gene and the “hedge” domain makes up the N-terminal of...
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...“The executives at companies that went from good to great and sustained that performance for 15 years or more were all cut from the same cloth. It didn’t matter when the transition took place... the successful organisations all had a level 5 leader at the time of the transition” (Collins 2001) Discuss the importance of leadership in the context of developing corporate strategy. (Summer 07) Leadership is incredibly important in developing corporate strategy. Good leadership and bad leadership can have huge beneficial/detrimental effect to a company and its strategy development. There are many dimensions of leadership such as: * Leadership and Teamwork: Leading the individuals and promoting teamwork in the team/division that they are under. * Time management: Insuring time is spent wisely and deadlines are met. * Decision-making and Problem solving: Leaders have to make decisions that will affect the whole team and come up with solutions to problems that they encounter along the way. * Creativity and Innovation: Leaders have to be creative and innovative as they strive to get the best out of the group of people that they are working with. * Motivation: Leaders have to motivate their team in whatever task they are involved in. * Communication and Presentation: Leaders communication skills will have to be excellent as they have to communicate not only to the team they are working with, but also their supervisors. * Vocation: Leaders have to be passionate...
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...Contents About the Author……………………………………….3 Thesis…………………………………………………...3 Chapter 1. Good is the Enemy of Great……………...4 Chapter 2.Level 5 Leadership………………………..5 Chapter 3. First Who….Then what…………………..6 Chapter 4. Confront the brutal facts…………………7 Chapter 5. Hedgehog Concept………………………9 Chapter 6. Cultural Discipline……………………….10 Chapter 7. Technological Accelerators…………….11 Chapter 8. The Flywheel And the Doom Loop…….12 Chapter 9. From Good To great To built to Last…..14 Learnings from Good to great……………………….15 Critique…………………………………………………16 . © www.hrfolks.com All Rights Reserved About the Author : Jim Collins is a student and teacher of enduring great companies -- how they grow, how they attain superior performance, and how good companies can become great companies. Having invested over a decade of research into the topic, Jim has co-authored three books, including the classic Built to Last, a fixture on the Business Week bestseller list for s eliminated wasteful luxuries, like executive dining rooms, corporate jets, lavish vacation spots, etc., for the good of the co mpany - to other people, external factors, and good luck. All 11 of the featured companies had this type of leadership, charactmulti-year research projects and works with executives from the private, public, and social sectors. Jim has served as a teacher to senior executives and CEOs at corporations that include: Starbucks Coffee, Merck, Patagonia, American General, W.L. Gore, and hundreds more. He...
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...LEVEL 5 LEADERSHIP THE TRIUMPH OF HUMILITY AND FIERCE RESOLVE What catapults a company from merely good to truly great? A five-year research good to truly great? A five-year research project searched for the answer to that question, and its discoveries ought to change the way we think about leadership. The most powerfully transformative executives possess a paradoxical mixture pf personal humility and professional will. They are timid and ferocious. shy and fearless. They are rare -- and unstoppable. In 1971, a seemingly ordinary man named Darwin E. Smith was named chief executive of Kimberly-Clark, a stodgy old paper company whose stock had fallen 36% behind the general market during the previous 20 years. Smith, the company's mild-mannered in-house lawyer, wasn't so sure the board had made the right choice -- a feeling that was reinforced when a Kimberly-Clark director pulled him aside and reminded him that he lacked some of the qualifications for the position. But CEO he was, and CEO he remained for 20 years. What a 20 years it was. In that period, Smith created a stunning transformation at Kimberly-Clark, turning it into the leading consumer paper products company in the world. Under his stewardship, the company beat its rivals Scott Paper and Procter & Gamble. And in doing so, Kimberly-Clark generated cumulative stock returns that were 4.1 times greater than those of the general market, outperforming venerable companies such as Hewlett-Packard, 3M, Coca-Cola,...
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...executive in whom genuine personal humility blends with intense professional will. To learn that such CEOs exist still comes as a pleasant shock. But while the idea may sound counterintuitive today, it was downright heretical when Collins first wrote about it-the corporate scandals in the United States hadn't broken out, and almost everyone believed that CEOs should be charismatic, larger-than-life figures. Collins was the first to blow that belief out of the water. Level 5 Leadership TheTriumph of Humility and Fierce Resolve by Jim Collins What catapults a company from merely good to truly great? A five-year research project searched for the answer to that question, and its discoveries ought to change the v^ay we think about leadership. I n 1971, a seemingly ordinary man med Darwin E. Smith was named cfeief executive of Kimberly-Clark, a stodgy old paper company whose stock had fallen 36% behind the general market during the previous 20 years. Smith, the company's mild-mannered in-house lawyer, wasn't so sure the board had made the right choice - a feeling that was reinforced when a Kimberly-Clark director pulled him aside and reminded him that he lacked some of the qualifications for the...
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...in March 2001 , is actually a narrative presentation of the quest of Jim Collins and his team as they conducted a research study regarding company performance which rooted from a single question: Can a good company become a great company and, if so, how? This seed of question was planted in the mind of Collins when confronted by Bill Meehan that his book “Built to Last”, which was about “how you take a company with great results and turn it into an enduring great company of iconic stature”, is considered useless in the world of business. As pointed out by Meehan, the companies written in Built to Last “never had to turn themselves from good companies into great companies” as they were always great. Challenged, Jim Collins started the five-year research of how a good company can become great. The study of Collins turned out into another breakthrough as it was systematically planned and well-structured; from six long months of search and analyzing financial reports of hundreds or even thousands of companies, identifying which companies made the leap from good results to great results and sustained those results for at least fifteen years and still taking into account their independence to the industry performance in which they belong, presenting and debating ,debating and debating until they’ve found eleven good-to-great companies to further study. The research, backed up by strong evidences, proved that companies with histories of being nothing special can indeed outperform...
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...Correlated with these findings are the reduction of superficial neuromasts (SN) found within the eye orbit (EO) associated with but not exclusively determined by shh (sonic hedgehog) gene. His work supports the most recent of the three theories, asserting that the loss of vision is due to pleitropy. Yamamoto Yoshizawa has used this theory for the basis of much (of his work (4, 5, 6). With knowledge of the various populations Vibration Attraction Behavior and eye orbital superficial neuromasts, Yoshizawa and his team employed multiple non-visual constructive traits and eye regression by doing quantitative genetic analysis of crosses between surface fish and cavefish (5). (Figure 1) Using this method, it was shown that vibration related behavior and the sensory receptors found within the cavefish eye orbit are genetically correlated with reduced eye size. (Figure 1C) In an effort to further investigate this correlation...
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...Current research efforts- potential future develoments are being researched Because the overall incidence of skin cancer rates continue to increase, scientist continue to look for potential future developments for the risk management of cancer related to tanning and sunbathing. Researchers are currently looking for ways to decrease skin cancer rates and discover new prevention methods. Such areas include drugs, genetics, melanoma treatments, and potential vaccines.13, 14 Current research suggest that exposure to ultraviolet radiation as a young age are more likely to develop malignant melanoma.16 Based on the analysis of much data, individuals exposed to ultraviolet radiation at a young age are more likely to develop skin cancer.16 The...
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...eurons in the adult mouse brain can shape N the features and physiologies of nearby astroglial cells, according to a study published today (February 18) in Science . Researchers at McGill University in Montreal and their colleagues have identified a molecular signal called sonic hedgehog (Shh), secreted by neurons, that acts as the agent of change. “What’s very exciting about the paper is this notion that a cell’s fate might be determined—after it has already established its morphology and location in the brain—based on interactions with its neighbors,” said neurologist Ed Ruthazer of the Montreal Neurological Institute at McGill who was not involved in the research. “And the conversion is not superficial,” he added, “it really does seem to fundamentally reorganize the transcriptome of the cell.” Astroglia are nonneuronal cells in the central nervous system that generally support and modulate neuronal function. The mammalian brain has an assortment of astrocytes, which perform a variety of specialized functions. This diversity was largely thought to be established during embryogenesis and early postnatal development, said Keith Murai of McGill who led the new research. “But after that,” he said, “the properties of these cells were thought to be solidified . . . for the rest of their lives.” Murai and his colleagues had a different view, however. “Some of these [astrocytes] are so specialized around certain neural circuits that it was hard...
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...A BRIEF HISTORY OF MANAGEMENT “Those who cannot learn from history are doomed to repeat it.” —George Santayana The World of Work: Tony considers his style O n the way home from the restaurant—soon to be his restaurant, Tony thought—the news of his Whenever she visited the restaurant, she and Jerry would always end up huddled in one of the corner booths over her laptop screen or a spreadsheet printout discussing numbers—food costs, labor costs, and the figures for the latest marketing campaign to increase sales. Dawn always ended her visit by walking around and checking in with everyone to make sure they were doing okay. Since Jerry ran such a good crew, there were never any problems, but Tony wondered what Dawn’s reaction would have been if she had found any. Jerry’s style always seemed to Tony to be more about the people than the numbers. He obviously hit promotion finally started to sink in. Jerry’s promotion to regional manager didn’t give either of them a lot of time to manage the transition, so the day had been filled with a lot of information—forms, rules, regulations, guidelines, and plenty of tips and tricks from Jerry on how to cope with the unexpected. In the peace and quiet of his apartment, Tony started thinking back to his earlier days at the Taco Barn and to the many lessons he had learned from both Jerry and Dawn. They were very different in their approach to their jobs. Dawn was all about the numbers. 26 LEARNING objectives CH A P T ER ...
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...Madagascar Rainforest Madagascar, located approximately 400 kilometers east of Africa is the world's fourth largest island. Because of its isolation it is occupied by some of the most unusual and rare species of plants and animals on earth. Madagascar was at one time formerly an independent kingdom; became a French colony in 1896 and regained independence in 1960. During 1992-93, free presidential and National Assembly elections were held ending 17 years of single-party rule(Science 1990). The main historical problem with international trade has been the correlated destruction of the environment. This is especially true when it comes to the issue of deforestation. In Madagascar, (Economic Geography, 1993) people have been cutting down the forests for decades. Throughout the past century, much of the rainforests of Madagascar have disappeared. People have begun moving out of the cities, industries have started to expand, and the use of land for farming (particularly coffee) has dramatically increased. All of these phenomenons have led to the destruction of the forest of Madagascar. Many plants and animal species have been severely endangered due to the deforestation (New Scientist 1990). With a current population near 14 million and growing at roughly 3% yearly combined with a per capita income of $230 per year, the major threats to the remaining forest are driven by subsistence needs and cutting for fuel. This has become a major issue, not only because of the value...
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...The Truth About Philippine Mangoes 04/12/2011 by Vanjo Merano What is the first thing that comes in your mind when you hear the word “Mango”? If you will ask me that question, the first thing that I think of is the Philippines. In my opinion, I can say, Without any doubt, that the best mangoes that the world has ever tasted came from the Philippines. I know people from other mango producing countries will question my statement. However, I am confident to say that there is no other mango out there that can beat Philippine mangoes in terms of sweetness, sourness, size, and weight. I tried almost all the imported mango varieties here in the US — including local mangoes. They all taste different from the original Philippine Mango. There are even varieties here that says “Manila Mangoes” in the sticker, but the taste does not say so. There are many mango varieties in the Philippines. Champagne mango or Carabao mango is probably the most famous in terms of taste. This mango variety is the sweetest mango that I ever tasted. It is also the mango variety that the Philippines export to other countries. There are different strains (breed) produced from Carabao mango — one of which is called Sweet Elena. If I am not mistaken, this breed originated somewhere in Zambales. Sweet Elena mango is the sweetest that I ever had. It is probably the sweetest mango in the world. There are also the well loved Cebu and Guimaras mangoes which are of world class quality. Filipinos enjoy eating mango...
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...LITERATURE REVIEW ON SOFTWARE ENGINEERING FOR COMPUTER GAMES Name: Course: Date Page 1 Abstract Games have often been very common in the past period of time, but with the discovery of computer games, they have penetrated. In spite of the third vista to computer games which is verifiable, it pertains to investigating what characteristics those who play such games anticipate from the gaming using the computer. Permit us state the meaning of a computer game as a play which is undertaken with an aid of a computer program. This meaning still leaves behind some flexibility because it does not imply that the whole game happens in the computer. For instance, Chess may be played on the computer screen and on a true-globe board, heedless to whether the one who objects to the play is a computer application. Huizinga in his classic work defined play as ``an activity which proceeds within certain limits of time and space, in a visible order, according to rules freely accepted, and outside the sphere of necessity or material utility. The play mood is one of rapture and enthusiasm, and is sacred or festive in accordance with the occasion. A feeling of exaltation and tension accompanies the action, mirth and relaxation follow``. A lexicon likewise states the meaning of game as `‘a universal form of recreation generally including any activity engaged in for diversion or amusement and often establishing a situation that involves a contest or rivalry’`. Besides, Elliot...
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...Scientific Management - Scientific Management This essay will critically evaluate the scientific management’s importance and its contribution in the current management context. In this era of rapid economic development and industrial expansion of different nations, scientific management has enabled every nation to be involved in this global market. Scientific management is the theory which serves as the ‘backbone’ to many current management theories. Scientific management will be briefly described initially. After that, the essay will identify why scientific management is an important contribution to management theory when Frederick Taylor proposed it.... [tags: Business Employee Management] 1639 words (4.7 pages) $19.95 [preview] Scientific Management - Scientific Management Fredrick Taylor, the father of scientific management. He had a firm belief in "one best way" (Samson & Daft, 2003), of doing something. In the year 1899, Taylor held an experiment that involved German and Hungarian men, whose job involved some very heavy-duty work (Gabor, 2000). To his disappointment, men either refused to work, or wouldn't work to his expectations. The men hated him utterly; to the extent he required security when going home (Gabor, 2000). In his entire dilemma with his employers, in stepped Schmidt, a man not of intelligence but had the strength of a bull and an ox-like mentally required to reach the standards of Fredrick Taylor.... [tags: Taylorism Business Management Essays] ...
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...(07000) Algeria Dr. Salima Maouche Assistant Professor Department of English Language Faculty of Letters & Languages University of Abd Errahmane Mira, Bejaia (06000) Algeria ABSTRACT: Information and Communication Technology (ICT) has inevitable impacts on different industries and their performances. The tourism industry, as the largest and fastest growing industry in the world, cannot be excluded from this technology and its huge impacts. ICT provides information about tourist attractions in different destinations before travelling and improves tourists‘ satisfaction. Although Algeria has great tourism potentials, it still needs to be performed well in promoting its attractions to international tourists via ICT tools yet. This research explores the impact of ICT on foreign tourists‘ satisfaction of the tourism industry and uses Algerian tourist agencies as a case study, and proposes a model for the impact of ICT on sustainable tourism. Finally, it concludes that e-ticketing, e- reservation, online payment, multilingual and updated information websites are essential needs for planning strategies in the field of e- tourism. Also, it is recommended that the tourism authorities should develop e-tourism...
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