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Niacin-Zinc Reaction Lab Report

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Niacin-zinc interaction
Vitamin B3 (Niacin), which is also known as nicotinic acid (NA) and nicotinamide in general, is considered as major antioxidant since it influences multiple pathways tied to both cellular survival and cellular death. Dietary nicotinic acid is rapidly absorbed through intestine and gets converted to nicotinamide in the liver or through the hydrolysis of NAD+.
Vannucchi et al. (1986) demonstrated the interaction between niacin, vitamin B6 and zinc in rats receiving ethanol with zinc repletion resulting in activation of niacin metabolism. These interactions were further confirmed in alcoholic pellagra patients (Vannucchi et al., 1989). The researchers also indicated the possibility of obtaining therapeutic benefits by …show more content…
Ex vivo zinc uptake by human erythrocytes was studied using blood samples of 10 healthy subjects when 8 mmoles of nicotinic acid or NADP increased 65zinc uptake by 38.9% and 43.1% in fasting, and by 70.9% and 28.1% in postprandial conditions. In one animal experiment, nicotinic acid supplementation to finger millet based diet resulted in significant (P < 0.05) enhancement of % zinc absorption, liver zinc and growth of weanling mice. In the second experiment, when mice were fed with NA deficient, -adequate and -excess diets for four weeks, in comparison with the nicotinic acid-deficient diet, % zinc absorption, intestinal zinc, % hemoglobin and liver iron were increased significantly under nicotinic acid-adequate and -excess conditions (Agte et al., …show more content…
NA in combination with zinc has been assessed in clinical studies for the treatment of inflammatory skin diseases such as acne vulgaris and bullous pemphigoid. The basis for these investigations is the variety of potential mechanisms of action of nicotinamide and zinc, including an anti-inflammatory effect, bacteriostatic effect against Propionibacterium acnes, inhibition of vasoactive amines, preservation of intracellular coenzyme homeostasis, decreased sebum production, suppression of vascular permeability and inflammatory cell accumulation, as well as protection against DNA damage (Fivenson, 2006). Our results have indicated the potential of this combination for

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